Recombinant Mouse BMPR-IA/ALK-3 Fc Chimera Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bone Morphogenetic Protein Receptor IA (BMPR-IA), also known as ALK-3, BRK-1, and CD292, is a glycosylated 60 ‑ 65 kDa type I receptor in the TGF‑ beta serine/threonine kinase receptor family (1 ‑ 3). Binding of TGF‑ beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins (1, 2). Mature mouse BMPR-IA consisits of a 129 amino acid (aa) extracellular domain (ECD), a 24 aa transmembrane segment, and a 356 aa cytoplasmic region that contains the tyrosine kinase domain (4, 5). Within the ECD, mouse BMPR-IA shares 98% aa sequence identity with human and rat BMPR-IA. BMPR-IA is involved in the development and function of a wide range of tissues. During early embryogenesis it is required for migration of the anterior visceral endoderm (AVE) and proper development of the anterior-posterior axis (6). Tissue-specific conditional knockout experiments have demonstrated the importance of BMPR-IA in the development and morphogenesis of the heart, lung, palate, teeth, and mandible (7 - 9). In the adult, BMPR-IA plays a role in glucose-stimulated insulin secretion by pancreatic beta cells, osteoclast activity and bone remodeling, reactive astrocyte-mediated scar formation following spinal cord injury, and ovulation and fertility (10 - 13).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: Bioassay, ELISA (Standard), In Vivo.

Showing Publications 1 - 4 of 4.

Publications using 437-MR	Applications	Species
Chen , Jiekai, Liu , He, Liu , Jing, Qi , Jing, Wei , Bei, Yang , Jiaqi, Liang , Hanquan, Chen , You, Chen , Jing, Wu , Yaran, Guo , Lin, Zhu , Jieying, Zhao , Xiangjie, Peng , Tianran, Zhang , Yixin, Chen , Shen, Li , Xuejia, Li , Dongwei, Wang , Tao, Pei , Duanqing H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2012-12-02;45(1):34-42. 2012-12-02 [PMID: 23202127] (Bioassay, Mouse)	Bioassay	Mouse
Ono Y, Calhabeu F, Morgan JE BMP signalling permits population expansion by preventing premature myogenic differentiation in muscle satellite cells. Cell Death Differ., 2010-08-06;18(2):222-34. 2010-08-06 [PMID: 20689554] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
Niessen K, Zhang G, Ridgway JB, Chen H, Yan M ALK1 signaling regulates early postnatal lymphatic vessel development. Blood, 2009-11-10;115(8):1654-61. 2009-11-10 [PMID: 19903896] (ELISA (Standard))	ELISA (Standard)
Lopez-Coviella I, Mellott TM, Kovacheva VP, Berse B, Slack BE, Zemelko V, Schnitzler A, Blusztajn JK Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain. Brain Res., 2006-04-13;1088(1):49-56. 2006-04-13 [PMID: 16626664] (Bioassay, Mouse)	Bioassay	Mouse

Array 437-MR

• BMPR-IA/ALK-3 Antibodies
• BMPR-IA/ALK-3 ELISA Kits
• BMPR-IA/ALK-3 Proteins and Enzymes