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BMPR-IB/ALK-6 Antibody (88614) [Unconjugated]

 (11 Publications)
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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB
Clone
88614
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB505-SP
Carrier Free
MAB505-500
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BMPR-IB/ALK-6 Antibody (88614) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human BMPR-IB/ALK-6
Lys14-Arg126
Accession # O00238
Specificity
Detects human and mouse BMPR-IB/ALK-6 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross‑reactivity with recombinant mouse (rm) BMPR‑IB and no cross‑reactivity with recombinant human (rh) BMPR‑IA, rmBMPR‑IA, or rhBMPR‑II is observed.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
BMPR1B
Purity Statement
Protein A or G purified from ascites
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB505 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BMPR-IB/ALK-6 Antibody (88614) [Unconjugated]

  • activin receptor-like kinase 6
  • ALK-6
  • ALK6CDw293
  • BMP type-1B receptor
  • BMPR1B
  • BMPR-1B
  • BMPRIB
  • BMPR-IB
  • bone morphogenetic protein receptor type-1B
  • bone morphogenetic protein receptor, type IB
  • CDw293 antigen
  • CDw293
  • EC 2.7.11
  • EC 2.7.11.30
  • serine/threonine receptor kinase

Background

BMPR-IB, also known as ALK-6, is a type I serine/threonine kinase receptor that associates with a type II TGF-beta receptor superfamily member to form a heteromeric signaling receptor complex. BMPR-IB is expressed during embryogenesis and in adult brain, bone, and hematopoietic stem cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for BMPR-IB/ALK-6 Antibody (MAB505)(11)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: ELISA Development, ICC, IHC, IHC-P, Western Blot.


Filter By Application
ELISA Development
(1)
ICC
(1)
IHC
(1)
IHC-P
(1)
Western Blot
(3)
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Human
(5)
Mouse
(2)
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Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using MAB505 Applications Species
Meng Z, Zhang S, Li W et al. Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis European heart journal 6/3/2023 [PMID: 37279475]
Chengyu Li, Xueqin Meng, Shuo Liu, Weijian Li, Xue Zhang, Jilong Zhou et al. Oocytes and hypoxanthine orchestrate the G2-M switch mechanism in ovarian granulosa cells Development 2020-07-01 [PMID: 32620578]
V Veschi, LR Mangiapane, A Nicotra, S Di Franco, E Scavo, T Apuzzo, DS Sardina, M Fiori, A Benfante, ML Colorito, G Cocorullo, F Giuliante, C Cipolla, G Pistone, MR Bongiorno, A Rizzo, CM Tate, X Wu, S Rowlinson, LF Stancato, M Todaro, R De Maria, G Stassi Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant Oncogene, 2019-10-07;0(0):. 2019-10-07 [PMID: 31591478] (ICC, Human) ICC Human
A Ribeiro, C Freitas, L Matos, A Gouveia, F Gomes, JL Silva Carv, H Almeida Age-related expression of TGF beta family receptors in human cumulus oophorus cells J. Assist. Reprod. Genet., 2017-05-02;0(0):. 5/2/2017 [PMID: 28466233]
Andrew J. Whittle, Meizi Jiang, Vivian Peirce, Joana Relat, Sam Virtue, Hiroyuki Ebinuma et al. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans Nature Communications 2015-11-20 [PMID: 26584636]
Beckham JD, Tuttle K, Tyler KL Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection. J. Virol., 2009-03-11;83(10):5035-45. 2009-03-11 [PMID: 19279118] (Western Blot, Mouse) Western Blot Mouse
Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol., 2008-07-02;381(4):1025-39. 2008-07-02 [PMID: 18621057] (ELISA Development, Human) ELISA Development Human
Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J. Pathol., 2008-01-01;214(1):85-95. 2008-01-01 [PMID: 17992660] (IHC, Human) IHC Human
Alejandre-Alcazar MA, Kwapiszewska G, Reiss I, Amarie OV, Marsh LM, Sevilla-Perez J, Wygrecka M, Eul B, Kobrich S, Hesse M, Schermuly RT, Seeger W, Eickelberg O, Morty RE Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia. Am. J. Physiol. Lung Cell Mol. Physiol., 2006-10-27;292(2):L537-49. 2006-10-27 [PMID: 17071723] (Western Blot, Mouse) Western Blot Mouse
Bleuming SA, Kodach LL, Garcia Leon MJ, Richel DJ, Peppelenbosch MP, Reitsma PH, Hardwick JC, van den Brink GR Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach. J. Pathol., 2006-06-01;209(2):190-7. 2006-06-01 [PMID: 16550632] (IHC-P, Human) IHC-P Human
Show All 11 Publications.

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Bioinformatics

Gene Symbol BMPR1B
Uniprot