Recombinant Human IFN-beta Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon beta (IFN-beta ), also known as fibroblast IFN, is a secreted, approximately 22 kDa member of the type I interferon family of molecules (1). Mature human IFN-beta shares 47% and 46% amino acid sequence identity with the mouse and rat proteins, respectively. Fibroblasts are the major producers of IFN-beta , but it can also be produced by dendritic cells, macrophages, and endothelial cells in response to pathogen exposure (2). It is transcriptionally regulated by TRAF3, IRF3, IRF7, and NF-kappa B (3, 4). Following secretion, IFN-beta signals through the heterodimeric IFN-alpha / beta Receptor and activates the JAK/STAT signaling pathway (5-8). IFN-beta -deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS) (9). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS (10-14).

We have publications tested in 3 confirmed species: Human, Mouse, Primate - C. aethiops.

We have publications tested in 5 applications: Bioassay, Cell Culture, Differentiation, Spheroid Culture, Stimulation.

Showing Publications 1 - 10 of 38. Show All 38 Publications. Collapse Publications.

Publications using 8499-IF/CF	Applications	Species
A Ta, R Ricci-Azev, SO Vasudevan, SS Wright, P Kumari, MS Havira, M Surendran, VA Rathinam, SK Vanaja A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3 Nature Communications, 2023-04-11;14(1):2035. 2023-04-11 [PMID: 37041208] (Bioassay, Human)	Bioassay	Human
J Nassour, LG Aguiar, A Correia, TT Schmidt, L Mainz, S Przetocka, C Haggblom, N Tadepalle, A Williams, MN Shokhirev, SC Akincilar, V Tergaonkar, GS Shadel, J Karlseder Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis Nature, 2023-02-08;614(7949):767-773. 2023-02-08 [PMID: 36755096] (Bioassay, Human)	Bioassay	Human
WC Ng, SS Kwek, B Sun, M Yousefi, EZ Ong, HC Tan, AS Puschnik, KR Chan, YS Ooi, EE Ooi A fast-growing dengue virus mutant reveals a dual role of STING in response to infection Open Biology, 2022-12-14;12(12):220227. 2022-12-14 [PMID: 36514984] (Bioassay, Human)	Bioassay	Human
MW Kenaston, OH Pham, MJ Petit, PS Shah Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networks BMC Genomics, 2022-11-30;23(1):787. 2022-11-30 [PMID: 36451099] (Stimulation, Human)	Stimulation	Human
LE Langbein, E Sementino, Z Zhong, W Jiang, L Li, JR Testa, H Yang Data supporting the roles of BAP1, STING, and IFN-beta in ISGF3 activation in ccRCC Data in Brief, 2022-11-11;45(0):108743. 2022-11-11 [PMID: 36426057] (Bioassay, Human)	Bioassay	Human
ND Furtado, MM Gómez, IS de Mello, DR Fernandes, MC Bonaldo Phenotypic and Genetic Studies of the Viral Lineage Associated with the Recent Yellow Fever Outbreak in Brazil Viruses, 2022-08-19;14(8):. 2022-08-19 [PMID: 36016440] (Bioassay, Primate - C. aethiops)	Bioassay	Primate - C. aethiops
E Padron-Reg, M Ulaszewska, AD Douglas, AVS Hill, AJ Spencer STING-pathway modulation to enhance the immunogenicity of adenoviral-vectored vaccines Scientific Reports, 2022-08-24;12(1):14464. 2022-08-24 [PMID: 36002507] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
NR Choudhury, I Trus, G Heikel, M Wolczyk, J Szymanski, A Bolembach, RM Dos Santos, N Smith, M Trubitsyna, E Gaunt, P Digard, G Michlewski TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway Nucleic Acids Research, 2022-07-08;0(0):. 2022-07-08 [PMID: 35736141] (Bioassay, Human)	Bioassay	Human
KK Jang, ME Kaczmarek, S Dallari, YH Chen, T Tada, J Axelrad, NR Landau, KA Stapleford, K Cadwell Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection PloS Biology, 2022-03-31;20(3):e3001592. 2022-03-31 [PMID: 35358182] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
A Fedoriw, L Shi, S O'Brien, KN Smitheman, Y Wang, J Hou, C Sherk, S Rajapurkar, J Laraio, LJ Williams, C Xu, G Han, Q Feng, MT Bedford, L Wang, O Barbash, RG Kruger, P Hwu, HP Mohammad, W Peng Inhibiting Type I arginine methyltransferase activity promotes the T cell mediated antitumor immune response Cancer Immunology Research, 2022-04-01;0(0):. 2022-04-01 [PMID: 35181787] (Bioassay, Human)	Bioassay	Human
NL Ka, GY Lim, S Hwang, SS Kim, MO Lee IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer Cell Reports, 2021-12-21;37(12):110138. 2021-12-21 [PMID: 34936865] (Bioassay, Human)	Bioassay	Human
S Wüst, P Schad, S Burkart, M Binder Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses Cells, 2021-09-30;10(10):. 2021-09-30 [PMID: 34685580] (Stimulation, Human)	Stimulation	Human
C Winkler, M King, J Berthe, D Ferraioli, A Garuti, F Grillo, J Rodriguez-, L Ferrando, N Chopin, I Ray-Coquar, O Delpuech, D Bedognetti, A Ballestrer, E Leo, G Zoppoli SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer JCI Insight, 2021-09-22;6(18):. 2021-09-22 [PMID: 34549724] (Bioassay, Human)	Bioassay	Human
C Prelli Boz, R Nchioua, M Volcic, L Koepke, J Krüger, D Schütz, S Heller, CM Stürzel, D Kmiec, C Conzelmann, J Müller, F Zech, E Braun, R Gro beta , L Wettstein, T Weil, J Wei beta , F Diofano, AA Rodríguez, S Wiese, D Sauter, J Münch, C Goffinet, A Catanese, M Schön, TM Boeckers, S Stenger, K Sato, S Just, A Kleger, KMJ Sparrer, F Kirchhoff IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro Nature Communications, 2021-07-28;12(1):4584. 2021-07-28 [PMID: 34321474] (Bioassay, Human)	Bioassay	Human
X Yang, X Zhao, Y Zhu, Y Shen, Y Wang, P Lu, Z Jiang, H Pan, J Yang, J Xun, L Zhao, J Wang, Z Liang, X Shen, Y Liang, Q Lin, H Liang, L Jin, D Zhang, J Liu, B Wang, S Jiang, J Xu, H Wu, H Lu, H Zhu FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat MBio, 2021-07-20;0(0):e0079521. 2021-07-20 [PMID: 34281390] (Bioassay, Human)	Bioassay	Human
DP Strange, B Jiyarom, H Sadri-Arde, LH Cazares, TA Kenny, MD Ward, S Verma Paracrine IFN Response Limits ZIKV Infection in Human Sertoli Cells Frontiers in Microbiology, 2021-05-17;12(0):667146. 2021-05-17 [PMID: 34079533] (Bioassay, Human)	Bioassay	Human
X Yu, L Zhang, J Shen, Y Zhai, Q Jiang, M Yi, X Deng, Z Ruan, R Fang, Z Chen, X Ning, Z Jiang The STING phase-separator suppresses innate immune signalling Nature Cell Biology, 2021-04-08;23(4):330-340. 2021-04-08 [PMID: 33833429] (Bioassay, Human)	Bioassay	Human
R Tian, AJ Samelson, VV Rezelj, M Chen, GN Ramadoss, X Guo, AM Kain, QD Tran, SA Lim, I Lui, J Nunez, SJ Rockwood, N Liu, J Carlson-St, J Oki, T Maures, K Holden, JS Weissman, JA Wells, B Conklin, M Vignuzzi, M Kampmann BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2 bioRxiv : the preprint server for biology, 2021-09-20;0(0):. 2021-09-20 [PMID: 33501440] (Bioassay, Human)	Bioassay	Human
S Trump, S Lukassen, MS Anker, RL Chua, J Liebig, L Thürmann, VM Corman, M Binder, J Loske, C Klasa, T Krieger, BP Hennig, M Messingsch, F Pott, J Kazmierski, S Twardziok, JP Albrecht, J Eils, S Hadzibegov, A Lena, B Heidecker, T Bürgel, J Steinfeldt, C Goffinet, F Kurth, M Witzenrath, MT Völker, SD Müller, UG Liebert, N Ishaque, L Kaderali, LE Sander, C Drosten, S Laudi, R Eils, C Conrad, U Landmesser, I Lehmann Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19 Nature Biotechnology, 2020-12-24;0(0):. 2020-12-24 [PMID: 33361824] (Bioassay, Human)	Bioassay	Human
JE Rexach, D Polioudaki, A Yin, V Swarup, TS Chang, T Nguyen, A Sarkar, L Chen, J Huang, LC Lin, W Seeley, JQ Trojanowsk, D Malhotra, DH Geschwind Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression Cell Rep, 2020-11-17;33(7):108398. 2020-11-17 [PMID: 33207193] (Cell Culture, Human)	Cell Culture	Human
J Stebbing, G Sánchez Ni, M Falcone, S Youhanna, P Richardson, S Ottaviani, JX Shen, C Sommerauer, G Tiseo, L Ghiadoni, A Virdis, F Monzani, LR Rizos, F Forfori, A Avendaño-C, S De Marco, L Carrozzi, F Lena, PM Sánchez-Ju, LG Lacerenza, N Cesira, D Caldevilla, A Perrella, L Niccoli, LS Méndez, D Matarrese, D Goletti, YJ Tan, V Monteil, G Dranitsari, F Cantini, A Farcomeni, S Dutta, SK Burley, H Zhang, M Pistello, W Li, M Mas Romero, F Andrés Pre, RS Simón-Tale, R García-Mol, C Kutter, JH Felce, ZF Nizami, AG Miklosi, JM Penninger, F Menichetti, A Mirazimi, P Abizanda, VM Lauschke JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality Sci Adv, 2021-01-01;0(0):. 2021-01-01 [PMID: 33187978] (Spheroid Culture, Human)	Spheroid Culture	Human
R da Silva A, LG Quiambao, F Soldevila, A Sutherland, B Peters, A Sette Lack of evidence supporting a role of IFN-&beta and TGF-&beta in differential polarization of Bordetella pertussis specific-T cell responses Cytokine, 2020-09-29;137(0):155313. 2020-09-29 [PMID: 33002739] (Bioassay, Human)	Bioassay	Human
CH Kerr, MA Skinnider, DDT Andrews, AM Madero, QWT Chan, RG Stacey, N Stoynov, E Jan, LJ Foster Dynamic rewiring of the human interactome by interferon signaling Genome Biol., 2020-06-15;21(1):140. 2020-06-15 [PMID: 32539747] (Bioassay, Human)	Bioassay	Human
D Li, R Wu, W Guo, L Xie, Z Qiao, S Chen, J Zhu, C Huang, J Huang, B Chen, Y Qin, F Xu, F Ma STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production Cell Rep, 2019-10-29;29(5):1249-1260.e4. 2019-10-29 [PMID: 31665637] (Cell Culture, Human)	Cell Culture	Human
TE Ginting, S Christian, YO Larasati, J Suryatengg, IM Suriaprana, G Mathew Antiviral interferons induced by Newcastle disease virus (NDV) drive a tumor-selective apoptosis Sci Rep, 2019-10-22;9(1):15160. 2019-10-22 [PMID: 31641164] (Bioassay, Human)	Bioassay	Human
W Guo, J Wei, X Zhong, R Zang, H Lian, MM Hu, S Li, HB Shu, Q Yang SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA Cell. Mol. Immunol., 2019-09-11;0(0):. 2019-09-11 [PMID: 31511639] (Bioassay, Human)	Bioassay	Human
C Good, AI Wells, CB Coyne Type III interferon signaling restricts enterovirus 71 infection of goblet cells Sci Adv, 2019-03-06;5(3):eaau4255. 2019-03-06 [PMID: 30854425] (Bioassay, Human)	Bioassay	Human
H Xu, SJ Xu, SJ Xie, Y Zhang, JH Yang, WQ Zhang, MN Zheng, H Zhou, LH Qu MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway Elife, 2019-02-08;8(0):. 2019-02-08 [PMID: 30735121] (Bioassay, Human)	Bioassay	Human
P An, MT Sáenz Robl, AM Duray, PG Cantalupo, JM Pipas Human polyomavirus BKV infection of endothelial cells results in interferon pathway induction and persistence PLoS Pathog., 2019-01-08;15(1):e1007505. 2019-01-08 [PMID: 30620752] (Bioassay, Human)	Bioassay	Human
I Cañadas, R Thummalapa, JW Kim, S Kitajima, RW Jenkins, CL Christense, M Campisi, Y Kuang, Y Zhang, E Gjini, G Zhang, T Tian, DR Sen, D Miao, Y Imamura, T Thai, B Piel, H Terai, AR Aref, T Hagan, S Koyama, M Watanabe, H Baba, AE Adeni, CA Lydon, P Tamayo, Z Wei, M Herlyn, TU Barbie, R Uppaluri, LM Sholl, E Sicinska, J Sands, S Rodig, KK Wong, CP Paweletz, H Watanabe, DA Barbie Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses Nat. Med., 2018-07-23;0(0):. 2018-07-23 [PMID: 30038220] (Bioassay, Human)	Bioassay	Human
A Singanayag, N Glanville, JL Girkin, YM Ching, A Marcellini, JD Porter, M Toussaint, RP Walton, LJ Finney, J Aniscenko, J Zhu, MB Trujillo-T, MA Calderazzo, C Grainge, SL Loo, PC Veerati, PS Pathinayak, KS Nichol, AT Reid, PL James, R Solari, PAB Wark, DA Knight, MF Moffatt, WO Cookson, MR Edwards, P Mallia, NW Bartlett, SL Johnston Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations Nat Commun, 2018-06-08;9(1):2229. 2018-06-08 [PMID: 29884817] (Bioassay, Human)	Bioassay	Human
MK Holly, JG Smith Adenovirus infection of human enteroids reveals interferon sensitivity and preferential infection of goblet cells J. Virol., 2018-04-13;0(0):. 2018-04-13 [PMID: 29467318] (Bioassay, Human)	Bioassay	Human
T Vougioukla, R Bao, Y Nakamura, V Saloura Protein methyltransferases and demethylases dictate CD8+ T-cell exclusion in squamous cell carcinoma of the head and neck Oncotarget, 2017-11-22;8(68):112797-112808. 2017-11-22 [PMID: 29348866] (Bioassay, Human)	Bioassay	Human
R Fang, C Wang, Q Jiang, M Lv, P Gao, X Yu, P Mu, R Zhang, S Bi, JM Feng, Z Jiang NEMO-IKK? Are Essential for IRF3 and NF-?B Activation in the cGAS-STING Pathway J. Immunol., 2017-09-22;0(0):. 2017-09-22 [PMID: 28939760] (Bioassay, Human)	Bioassay	Human
J Corry, N Arora, CA Good, Y Sadovsky, CB Coyne Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface Proc. Natl. Acad. Sci. U.S.A., 2017-08-07;0(0):. 2017-08-07 [PMID: 28784796] (Bioassay, Human)	Bioassay	Human
X Dai, M Tohyama, M Murakami, K Sayama Epidermal keratinocytes sense dsRNA via the NLRP3 inflammasome, mediating interleukin (IL)-1? and IL-18 release Exp. Dermatol, 2017-05-12;0(0):. 2017-05-12 [PMID: 28266737] (Bioassay, Human)	Bioassay	Human
HC Hsia, JE Hutti, AS Baldwin Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding kinase 1 (TBK1) to Restrain STAT3 Activity J. Biol. Chem, 2017-02-10;0(0):. 2017-02-10 [PMID: 28188292] (Bioassay, Human)	Bioassay	Human
J Worthingto, G Spain, JF Timms Effects of ErbB2 Overexpression on the Proteome and ErbB Ligand-specific Phosphosignaling in Mammary Luminal Epithelial Cells Mol. Cell Proteomics, 2017-02-07;16(4):608-621. 2017-02-07 [PMID: 28174229] (Bioassay, Human)	Bioassay	Human
Show All 38 Publications. Collapse Publications.

Array 8499-IF/CF

• IFN-beta Antibodies
• IFN-beta ELISA Kits
• IFN-beta Lysate
• IFN-beta Proteins
• IFN-beta ELISAs
• IFN-beta Proteins and Enzymes