Recombinant Human IFN-beta 1a (Mammalian) Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

We have publications tested in 2 confirmed species: Human, Primate.

We have publications tested in 2 applications: Bioassay, Control.

Showing Publications 1 - 7 of 7.

Publications using 11410-2	Applications	Species
MA Cron, CA Payet, OM Fayet, S Maillard, F Truffault, E Fadel, J Guihaire, S Berrih-Akn, A Liston, R Le Panse Decreased expression of miR-29 family associated with autoimmune myasthenia gravis J Neuroinflammation, 2020-10-08;17(1):294. 2020-10-08 [PMID: 33032631] (Bioassay, Human)	Bioassay	Human
Rasouli J, Ciric B, Imitola J, Gonnella P, Hwang D, Mahajan K, Mari E, Safavi F, Leist T, Zhang G, Rostami A Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-beta Therapy. J Immunol, 2015-04-27;194(11):5085-93. 2015-04-27 [PMID: 25917097] (Bioassay, Human)	Bioassay	Human
Li , Yanfang, Chen , Sujuan, Zhang , Xiaojian, Fu , Qiang, Zhang , Zhiye, Shi , Shaohua, Zhu , Yinbiao, Gu , Min, Peng , Daxin, Liu , Xiufan A 20-amino-acid deletion in the neuraminidase stalk and a five-amino-acid deletion in the NS1 protein both contribute to the pathogenicity of H5N1 avian influenza viruses in mallard ducks. PLoS ONE, 2014-04-17;9(4):e95539. 2014-04-17 [PMID: 24743258] (Bioassay, Primate)	Bioassay	Primate
Salvi V, Scutera S, Rossi S, Zucca M, Alessandria M, Greco D, Bosisio D, Sozzani S, Musso T Dual regulation of osteopontin production by TLR stimulation in dendritic cells. J Leukoc Biol, 2013-04-22;94(1):147-58. 2013-04-22 [PMID: 23610145] (Bioassay, Human)	Bioassay	Human
Wang , Bei, Xi , Xueyan, Lei , Xiaobo, Zhang , Xiaoyan, Cui , Sheng, Wang , Jianwei, Jin , Qi, Zhao , Zhendong Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses. PLoS Pathog, 2013-03-21;9(3):e1003231. 2013-03-21 [PMID: 23555247] (Bioassay, Human)	Bioassay	Human
Popugaeva E, Witkowski PT, Schlegel M, Ulrich RG, Auste B, Rang A, Kruger DH, Klempa B Dobrava-Belgrade hantavirus from Germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans. PLoS ONE, 2012-04-24;7(4):e35587. 2012-04-24 [PMID: 22545121] (Control, Human)	Control	Human
Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun., 2009-10-01;10(8):702-14. 2009-10-01 [PMID: 19798076] (Bioassay, Human)	Bioassay	Human

Array 11410-2

• IFN-beta Antibodies
• IFN-beta ELISA Kits
• IFN-beta Lysate
• IFN-beta Proteins
• IFN-beta ELISAs
• IFN-beta Proteins and Enzymes