Recombinant Human Fibulin 1C Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Fibulin 1 is a 95 kDa matricellular glycoprotein component of the elastic fiber core in connective tissues (1-3). It contains 3 tandem anaphylatoxin-like domains followed by 9 tandem EGF-like domains (4). Alternative splicing of human Fibulin 1 generates additional isoforms with a deletion or substitution of the C-terminal 137 amino acids (aa) (4). The Fibulin 1c isoform carries a 117 aa substitution for this region which includes a portion of the ninth EGF-like domain and the C-terminal region. Human Fibulin 1c shares 86% aa sequence identity with mouse and rat Fibulin 1c. It self-aggregates and additionally binds to several extracellular matrix and cellular proteins including Aggrecan, Versican, Fibronectin, ECM1, NOV/CCN3, and pro-HB-EGF (5-9). Fibulin 1c enhances ADAMTS-1 mediated cleavage of Aggrecan and Versican (10, 11) and can itself be cleaved by neutrophil elastase or MMP-13 (12, 13). It functions as a bridge between Fibrinogen and Fibrin, enabling Fibrin attachment to the platelet cell surface via Integrin  alpha 2b beta 3 (14). Fibulin 1 inhibits cardiomyocyte proliferation and Fibronectin-mediated cell adhesion and can promote bone formation (11, 15, 16).

Array 9007-FB

• Fibulin 1 Antibodies
• Fibulin 1 ELISA Kits
• Fibulin 1 Lysate
• Fibulin 1 Proteins
• Fibulin 1 Proteins and Enzyme