Recombinant Human EN-RAGE Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

EN-RAGE, also known as S100A12 and Calgranulin C, is a 10 kDa member of the S100 (soluble in 100% saturated ammonium sulfate) family of EF-hand calcium-binding proteins. Like other S100 proteins, S100A12 is small and generally acidic (1 - 3). EN-RAGE forms noncovalent homodimers in the absence of divalent cations (4 - 6); calcium and zinc promote the formation of higher order assemblies including tetramers and hexamers (4, 7, 8). The ability of S100A12 to chelate zinc enables it to inhibit the zinc-dependent metalloproteases MMP-2, -3, and -9 (8). S100A12 also forms heterodimers with S100A9 and binds to RAGE (Receptor for Advanced Glycation End-products), Annexin V, and several cytosolic enzymes involved in energy metabolism (9, 10). The hexameric form of EN-RAGE in particular binds RAGE with high affinity (7). EN-RAGE induces a variety of inflammatory responses including the in vivo recruitment of neutrophils, monocytes, and mast cells and the activation of mast cells and vascular endothelial cells (9, 11 - 14). EN-RAGE is found at elevated levels under inflammatory conditions such as asthma, gout, rheumatoid arthritis synovial fluid, and atherosclerosis (8, 12, 14). S100A12 also promotes neurite outgrowth in isolated hippocampal neurons (15). An ortholog of S100A12 has not been identified in rodents, but the human protein is functional in mice and rats (11 - 16).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 2 of 2.

Publications using 1052-ER	Applications	Species
Yan L, Mathew L, Chellan B, Gardner B, Earley J, Puri T, Hofmann Bowman M S100/Calgranulin-mediated inflammation accelerates left ventricular hypertrophy and aortic valve sclerosis in chronic kidney disease in a receptor for advanced glycation end products-dependent manner. Arterioscler Thromb Vasc Biol, 2014-05-22;34(7):1399-411. 2014-05-22 [PMID: 24855059] (Bioassay, Mouse)	Bioassay	Mouse
Chellan B, Yan L, Sontag T, Reardon C, Hofmann Bowman M IL-22 is induced by S100/calgranulin and impairs cholesterol efflux in macrophages by downregulating ABCG1. J Lipid Res, 2013-12-23;55(3):443-54. 2013-12-23 [PMID: 24367046] (Bioassay, Human)	Bioassay	Human

Array 1052-ER

• EN-RAGE/S100A12 Antibodies
• EN-RAGE/S100A12 ELISA Kit
• EN-RAGE/S100A12 Lysate
• EN-RAGE/S100A12 Protein
• EN-RAGE/S100A12 ELISA
• EN-RAGE/S100A12 Proteins and Enzyme