EN-RAGE/S100A12 Products

Description

S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B--a key transcription factor for inflammatory events--is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.

Bioinformatics

Entrez	6283 Human
Uniprot	NM_005621 Human NP_005612 Human NP_005612.1 Human P80511 Human
Product By Gene ID	6283
Alternate Names	CAAF1Neutrophil S100 protein CAGCS100 calcium binding protein A12 (calgranulin C) Calcium-binding protein in amniotic fluid 1 Calgranulin-C calgranulin-C CGRPEN-RAGE ENRAGE Extracellular newly identified RAGE-binding protein MRP6 p6calgranulin C protein S100-A12 S100 calcium binding protein A12 S100 calcium-binding protein A12 (calgranulin C) S100 calcium-binding protein A12

Research Areas for EN-RAGE/S100A12

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cytokine Research
Immunology
Innate Immunity
Signal Transduction