Name: Recombinant Human CCL19/MIP-3 beta Protein, CF
Brand: Novus Biologicals
SKU: 361-MI/CF
Price: 396 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	Bioactivity
Format	Carrier-Free

Details of Functionality	Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR7. The ED₅₀ for this effect is 3-15 ng/mL.
Source	E. coli-derived human CCL19/MIP-3 beta protein Gly22-Ser98
Accession #	Q99731.1
N-terminal Sequence	Gly22
Protein/Peptide Type	Recombinant Proteins
Gene	CCL19
Purity	>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note	<0.10 EU per 1 μg of the protein by the LAL method.

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Purity	>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions	Reconstitute at 100 μg/mL in sterile PBS.

Publications using 361-MI/CF	Applications	Species
Z Su, J Brooks, J Pelker, T Andreyeva, H Sobon, R Gifford, M Powers, J Wang, C Dower, M Hegen, D Messing, AD Sheehan, JJ Brennan Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function PLoS ONE, 2023-01-20;18(1):e0280590. 2023-01-20 [PMID: 36662882] (Bioassay, Human)	Bioassay	Human
DA Covino, MG Desimio, M Doria Impact of IL-15 and latency reversing agent combinations in the reactivation and NK cell-mediated suppression of the HIV reservoir Scientific Reports, 2022-11-03;12(1):18567. 2022-11-03 [PMID: 36329160] (Bioassay, Human)	Bioassay	Human
W Piao, L Li, V Saxena, J Iyyathurai, R Lakhan, Y Zhang, IT Lape, C Paluskievi, KL Hippen, Y Lee, E Silverman, MW Shirkey, LV Riella, BR Blazar, JS Bromberg PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration Nature Communications, 2022-04-21;13(1):2176. 2022-04-21 [PMID: 35449134] (Bioassay, Human)	Bioassay	Human
EP Brandum, AS Jørgensen, MB Calvo, K Spiess, FC Peterson, Z Yang, BF Volkman, CT Veldkamp, MM Rosenkilde, CK Goth, GM Hjortø Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails International Journal of Molecular Sciences, 2022-01-26;23(3):. 2022-01-26 [PMID: 35163323] (Bioassay, Human)	Bioassay	Human
K Kurowarabe, M Endo, D Kobayashi, H Hayasaka CXCL12-stimulated lymphocytes produce secondary stimulants that affect the surrounding cell chemotaxis Biochemistry and Biophysics Reports, 2021-09-07;28(0):101128. 2021-09-07 [PMID: 34527817] (Bioassay, Human)	Bioassay	Human
GR Campbell, J Zhuang, G Zhang, I Landa, LJ Kubiatowic, D Dehaini, RH Fang, L Zhang, SA Spector CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells Theranostics, 2021-08-25;11(18):9009-9021. 2021-08-25 [PMID: 34522224] (Bioassay, Human)	Bioassay	Human
H Dhandapani, H Jayakumar, A Seetharama, SS Singh, S Ganeshraja, N Jagadish, A Suri, R Thangaraja, P Ramanathan Dendritic cells matured with recombinant human sperm associated antigen 9 (rhSPAG9) induce CD4+, CD8+ T cells and activate NK cells: a potential candidate molecule for immunotherapy in cervical cancer Cancer Cell International, 2021-09-07;21(1):473. 2021-09-07 [PMID: 34493268] (Bioassay, Human)	Bioassay	Human
T Liang, Q Zhang, Z Wu, P Chen, Y Huang, S Liu, L Li UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat MBio, 2021-08-31;12(4):e0162521. 2021-08-31 [PMID: 34465029] (Bioassay, Human)	Bioassay	Human
G Zhang, GR Campbell, Q Zhang, E Maule, J Hanna, W Gao, L Zhang, SA Spector CD4+ T Cell-Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication through Autophagy MBio, 2020-09-15;11(5):. 2020-09-15 [PMID: 32934078] (Cell Culture, Human)	Cell Culture	Human
G Khoury, C Mackenzie, L Ayadi, SR Lewin, C Branlant, DFJ Purcell Tat IRES modulator of tat mRNA (TIM-TAM): a conserved RNA structure that controls Tat expression and acts as a switch for HIV productive and latent infection Nucleic Acids Res., 2020-03-18;0(0):. 2020-03-18 [PMID: 31875221] (Cell Culture, Human)	Cell Culture	Human
S Caielli, DT Veiga, P Balasubram, S Athale, B Domic, E Murat, R Banchereau, Z Xu, M Chandra, CH Chung, L Walters, J Baisch, T Wright, M Punaro, L Nassi, K Stewart, J Fuller, D Ucar, H Ueno, J Zhou, J Banchereau, V Pascual A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate Nat. Med., 2018-11-26;0(0):. 2018-11-26 [PMID: 30478422] (Bioassay, Human)	Bioassay	Human
H Plešingero, P Janovská, A Mishra, L Smy?ková, L Poppová, A Libra, K Plevová, P Ovesná, L Radová, M Doubek, Š Pavlová, Š Pospíšilov, V Bryja Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia Haematologica, 2017-11-09;0(0):. 2017-11-09 [PMID: 29122990] (Bioassay, Human)	Bioassay	Human
D Kobayashi, M Endo, H Ochi, H Hojo, M Miyasaka, H Hayasaka Regulation of CCR7-dependent cell migration throughï¿½CCR7 homodimer formation Sci Rep, 2017-08-17;7(1):8536. 2017-08-17 [PMID: 28819198] (Bioassay, Human)	Bioassay	Human
JMJ Van den Be, ELJM Smits, M Versteven, H De Reu, ZN Berneman, VFI Van Tendel, E Lion Characterization of Interleukin-15-Transpresenting Dendritic Cells for Clinical Use J Immunol Res, 2017-07-13;2017(0):1975902. 2017-07-13 [PMID: 28785596] (Bioassay, Human)	Bioassay	Human
B Xu, M Zhou, W Qiu, J Ye, Q Feng CCR7 mediates human breast cancer cell invasion, migration by inducing epithelial-mesenchymal transition and suppressing apoptosis through AKT pathway Cancer Med, 2017-04-04;0(0):. 2017-04-04 [PMID: 28378417] (Bioassay, Human)	Bioassay	Human
RA Raposo, M de Mulder, D Paquin-Pro, PM Brailey, VD Cabido, PM Zdinak, AS Thomas, SH Huang, GA Beckerle, RB Jones, DF Nixon IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis JCI Insight, 2017-01-12;2(1):e85811. 2017-01-12 [PMID: 28097226] (Bioassay, Human)	Bioassay	Human
Dengue virus infection induces interferon-lambda1 to facilitate cell migration Sci Rep, 2016-07-26;6(0):24530. 2016-07-26 [PMID: 27456172] (Bioassay, Human)	Bioassay	Human
Human breast cancer-derived soluble factors facilitate CCL19-induced chemotaxis of human dendritic cells Sci Rep, 2016-07-25;6(0):30207. 2016-07-25 [PMID: 27451948] (Bioassay, Human)	Bioassay	Human
RB Jones, S Mueller, R O'Connor, K Rimpel, DD Sloan, D Karel, HC Wong, EK Jeng, AS Thomas, JB Whitney, SY Lim, C Kovacs, E Benko, S Karandish, SH Huang, MJ Buzon, M Lichterfel, A Irrinki, JP Murry, A Tsai, H Yu, R Geleziunas, A Trocha, MA Ostrowski, Irvi A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes PLoS Pathog, 2016-04-15;12(4):e1005545. 2016-04-15 [PMID: 27082643] (Bioassay, Human)	Bioassay	Human
Janovska P, Poppova L, Plevova K, Plesingerova H, Behal M, Kaucka M, Ovesna P, Hlozkova M, Borsky M, Stehlikova O, Brychtova Y, Doubek M, Machalova M, Baskar S, Kozubik A, Pospisilova S, Pavlova S, Bryja V Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia. Clin Cancer Res, 2015-08-03;22(2):459-69. 2015-08-03 [PMID: 26240275] (Bioassay, Human)	Bioassay	Human
Kaucka M, Petersen J, Janovska P, Radaszkiewicz T, Smyckova L, Daulat A, Borg J, Schulte G, Bryja V Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway. Cell Commun Signal, 2015-01-28;13(0):2. 2015-01-28 [PMID: 25627785] (Bioassay, Human)	Bioassay	Human
Cerny D, Haniffa M, Shin A, Bigliardi P, Tan B, Lee B, Poidinger M, Tan E, Ginhoux F, Fink K Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection. PLoS Pathog, 2014-12-04;10(12):e1004548. 2014-12-04 [PMID: 25474532] (Bioassay, Human)	Bioassay	Human
Ramachandran M, Jin C, Yu D, Eriksson F, Essand M Vector-encoded Helicobacter pylori neutrophil-activating protein promotes maturation of dendritic cells with Th1 polarization and improved migration. J Immunol, 2014-07-21;193(5):2287-96. 2014-07-21 [PMID: 25049358] (Bioassay, Human)	Bioassay	Human
Hofbauer , Sebastia, Krenn , Peter W, Ganghammer , Sylvia, Asslaber , Daniela, Pichler , Ulrike, Oberascher , Karin, Henschler , Reinhard, Wallner , Michael, Kerschbaum , Hubert, Greil , Richard, Hartmann , Tanja N Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells. Blood, 2014-02-05;123(14):2181-8. 2014-02-05 [PMID: 24501217] (Bioassay, Human)	Bioassay	Human
Spina , Celsa A, Anderson , Jenny, Archin , Nancie M, Bosque , Alberto, Chan , Jonathan, Famiglietti , Marylind, Greene , Warner C, Kashuba , Angela, Lewin , Sharon R, Margolis , David M, Mau , Matthew, Ruelas , Debbie, Saleh , Suha, Shirakawa , Kotaro, Siliciano , Robert F, Singhania , Akul, Soto , Paula C, Terry , Valeri H, Verdin , Eric, Woelk , Christop, Wooden , Stacey, Xing , Sifei, Planelles , Vicente An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. PLoS Pathog, 2013-12-26;9(12):e1003834. 2013-12-26 [PMID: 24385908] (Bioassay, Human)	Bioassay	Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human
Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. Eur. J. Immunol., 2012-04-01;42(4):936-45. 2012-04-01 [PMID: 22531918] (Bioassay, Human)	Bioassay	Human
Beck B, Dorfel D, Lichtenegger FS, Geiger C, Lindner L, Merk M, Schendel DJ, Subklewe M Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission. J Transl Med, 2011-09-13;9(0):151. 2011-09-13 [PMID: 21910911] (Bioassay, Human)	Bioassay	Human
Berrih-Aknin S, Ruhlmann N, Bismuth J, Cizeron-Clairac G, Zelman E, Shachar I, Dartevelle P, de Rosbo NK, Le Panse R CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia. Ann. Neurol., 2009-10-01;66(4):521-31. 2009-10-01 [PMID: 19847900] (ELISA (Standard))	ELISA (Standard)
Damas JK, Landro L, Fevang B, Heggelund L, Tjonnfjord GE, Floisand Y, Halvorsen B, Froland SS, Aukrust P Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication. Clin. Exp. Immunol., 2009-09-01;157(3):400-7. 2009-09-01 [PMID: 19664149] (Bioassay, Human)	Bioassay	Human
Bonecchi R, Borroni EM, Anselmo A, Doni A, Savino B, Mirolo M, Fabbri M, Jala VR, Haribabu B, Mantovani A, Locati M Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation. Blood, 2008-05-14;112(3):493-503. 2008-05-14 [PMID: 18480427] (Bioassay, Human)	Bioassay	Human
Lim HW, Kim CH Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue. J. Immunol., 2007-12-01;179(11):7448-56. 2007-12-01 [PMID: 18025189] (Bioassay, Human)	Bioassay	Human
Bayry J, Triebel F, Kaveri SV, Tough DF Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. J. Immunol., 2007-04-01;178(7):4184-93. 2007-04-01 [PMID: 17371975] (Bioassay, Human)	Bioassay	Human
Kriegova E, Tsyrulnyk A, Arakelyan A, Mrazek F, Ordeltova M, Petzmann S, Zatloukal J, Kolek V, du Bois RM, Popper H, Petrek M Expression of CCX CKR in pulmonary sarcoidosis. Inflamm. Res., 2006-10-01;55(10):441-5. 2006-10-01 [PMID: 17109071] (Bioassay, Human)	Bioassay	Human
Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J. Immunol., 2006-10-01;177(7):4488-94. 2006-10-01 [PMID: 16982885] (Bioassay, Human)	Bioassay	Human
Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, Nagakubo D, Saito T, Shimomura Y, Yoshie O Novel antiviral activity of chemokines. Virology, 2006-04-17;350(2):484-92. 2006-04-17 [PMID: 16603217] (Binding Assay, Bioassay, Virus)	Binding Assay, Bioassay	Virus
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J. Immunol., 2004-12-01;173(11):6592-602. 2004-12-01 [PMID: 15557149] (Bioassay, Human)	Bioassay	Human
Curiel , Tyler J, Coukos , George, Zou , Linhua, Alvarez , Xavier, Cheng , Pui, Mottram , Peter, Evdemon-Hogan , Melina, Conejo-Garcia , Jose R, Zhang , Lin, Burow , Matthew, Zhu , Yun, Wei , Shuang, Kryczek , Ilona, Daniel , Ben, Gordon , Alan, Myers , Leann, Lackner , Andrew, Disis , Mary L, Knutson , Keith L, Chen , Lieping, Zou , Weiping Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med, 2004-08-22;10(9):942-9. 2004-08-22 [PMID: 15322536] (Bioassay, Human)	Bioassay	Human
Chang WL, Baumgarth N, Yu D, Barry PA Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality. J. Virol., 2004-08-01;78(16):8720-31. 2004-08-01 [PMID: 15280480] (Bioassay, Human)	Bioassay	Human
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Recombinant Human CCL19/MIP-3 beta Protein, CF

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Catalog# & Formulation	Size	Price
Standard Formulation 361-MI-025

Gene Symbol	CCL19
Uniprot	Q99731.1()