Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bone Morphogenetic Protein Receptor IA (BMPR-IA), also known as ALK-3, BRK-1, and CD292, is a glycosylated 60 - 65 kDa type I receptor in the TGF‑ beta serine/threonine kinase receptor family (1 ‑ 3). Binding of TGF-beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins (1, 2). Mature human BMPR-IA consisits of a 129 amino acid (aa) extracellular domain (ECD), a 24 aa transmembrane segment, and a 356 aa cytoplasmic region that contains the tyrosine kinase domain (4). Within the ECD, human BMPR-IA shares 98% and 97% aa sequence identity with mouse and rat BMPR-IA, respectively. BMPR-IA is involved in the development and function of a wide range of tissues. During early embryogenesis it is required for migration of the anterior visceral endoderm (AVE) and proper development of the anterior-posterior axis (5). Tissue-specific conditional knockout experiments have demonstrated the importance of BMPR-IA in the development and morphogenesis of the heart, lung, palate, teeth, and mandible (6 - 8). In the adult, BMPR-IA plays a role in glucose-stimulated insulin secretion by pancreatic beta cells, osteoclast activity and bone remodeling, reactive astrocyte-mediated scar formation following spinal cord injury, and ovulation and fertility (9 - 12).

We have publications tested in 2 confirmed species: Human, Chicken.

We have publications tested in 4 applications: Bioassay, ELISA (detection), Receptor Binding Assay, Surface Plasmon Resonance.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using 315-BR	Applications	Species
T Mang, K Kleinschmi, F Ploeger, A Schoeneman, S Lindemann, A Gigout BMPR1A is necessary for chondrogenesis and osteogenesis while BMPR1B prevents hypertrophic differentiation J. Cell. Sci., 2020-08-21;0(0):. 2020-08-21 [PMID: 32764110] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
Martinez V, Sacedon R, Hidalgo L, Valencia J, Fernandez-Sevilla L, Hernandez-Lopez C, Vicente A, Varas A The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis. PLoS ONE, 2015-06-25;10(6):e0131453. 2015-06-25 [PMID: 26110906] (Bioassay, Human)	Bioassay	Human
Woltje K, Jabs M, Fischer A Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS ONE, 2015-03-23;10(3):e0120547. 2015-03-23 [PMID: 25799559] (Bioassay, Human)	Bioassay	Human
Bigley V, McGovern N, Milne P, Dickinson R, Pagan S, Cookson S, Haniffa M, Collin M Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells. J Leukoc Biol, 2014-12-16;97(4):627-34. 2014-12-16 [PMID: 25516751] (Bioassay, Human)	Bioassay	Human
Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, Kaniewski B, Ffrench M, Salesse S, Nicolini F, Maguer-Satta V Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression. Blood, 2013-10-07;122(23):3767-77. 2013-10-07 [PMID: 24100446] (Bioassay, Human)	Bioassay	Human
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-07-07;286(34):30034-46. 2011-07-07 [PMID: 21737454] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
Steinbicker AU, Sachidanandan C, Vonner AJ Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood, 2011-03-10;117(18):4915-23. 2011-03-10 [PMID: 21393479] (Bioassay, Human)	Bioassay	Human
Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood, 2008-07-29;112(8):3154-63. 2008-07-29 [PMID: 18664625] (Bioassay, Human)	Bioassay	Human
Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol., 2008-07-02;381(4):1025-39. 2008-07-02 [PMID: 18621057] (ELISA (detection), Surface Plasmon Resonance, Human)	ELISA (detection), Surface Plasmon Resonance	Human
David L, Mallet C, Mazerbourg S, Feige JJ, Bailly S Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood, 2006-10-26;109(5):1953-61. 2006-10-26 [PMID: 17068149] (Bioassay, Human)	Bioassay	Human
Reversade B, De Robertis EM Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell, 2005-12-16;123(6):1147-60. 2005-12-16 [PMID: 16360041] (Receptor Binding Assay, Human)	Receptor Binding Assay	Human
Gunhaga L, Marklund M, Sjodal M, Hsieh JC, Jessell TM, Edlund T Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat. Neurosci., 2003-07-01;6(7):701-7. 2003-07-01 [PMID: 12766771] (Bioassay, Chicken)	Bioassay	Chicken
Show All 12 Publications. Collapse Publications.

Array 315-BR

• BMPR-IA/ALK-3 Antibodies
• BMPR-IA/ALK-3 ELISA Kits
• BMPR-IA/ALK-3 Proteins and Enzymes