Recombinant Human ASIP/Agouti Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Agouti, also known as Agouti Signaling Protein (ASIP), is a 132 amino peptide that regulates hair pigmentation in mice and adipocyte metabolism in humans (1). Mature human Agouti shares 78% and 76% amino acid sequence identity with mouse and rat Agouti, respectively (2, 3). Human Agouti is primarily expressed in adipose tissue, whereas its adipose expression in mice is only induced by mutations in the Agouti promoter (4, 5). Agouti is also expressed in the pancreas where it enhances the production of insulin by beta cells (6). Agouti functions as a competitive antagonist at several melanocortin receptors. It blocks ACTH binding to MC1R and MSH binding to MC1R, MC3R, and MC4R (7-9). It blocks MSH induced effects on melanocytes including proliferation and melanin production (3, 7, 8).

Array 9094-AG

• ASIP Antibodies
• ASIP Lysate
• ASIP Proteins and Enzymes