Complement Factor D/Adipsin Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Complement Factor D (also Adipsin, C3 convertase activator and Properdin factor D) is a 37‑43 kDa member of the S1 peptidase family of enzymes. In mouse, it is secreted by fat cells and helps form C3 convertase, a complex of C3b, Factor B and Factor D. This complex cleaves C3 into C3b and C3a, the latter of which is converted into ASP, a molecule that binds the adipocyte receptor C5L2 and induces triglyceride synthesis. Mature mouse Factor D is 234 amino acids (aa) in length (aa 26‑259). In contains one peptidase S1 domain that cleaves an Arg-Lys bond (aa 26‑254). There are at least two potential alternative splice forms. One shows a two aa substitution for aa 1‑71, and a second shows a 15 aa substitution for aa 1‑107. Mature mouse factor D shares 85% and 68% aa identity with rat and human Factor D, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IHC, Western Blot.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using AF5430	Applications	Species
He, Y;Zhang, R;Yu, L;Zahr, T;Li, X;Kim, TW;Qiang, L; PPAR gamma Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction Cells 5/18/2023 [PMID: 37408258]
Nicole Aaron, Tarik Zahr, Ying He, Lexiang Yu, Brent Mayfield, Utpal B. Pajvani et al. Acetylation of PPAR gamma in macrophages promotes visceral fat degeneration in obesity Life Metabolism 2023-05-22 [PMID: 37213714]
Wan, Q;Calhoun, C;Zahr, T;Qiang, L; Uncoupling Lipid Synthesis from Adipocyte Development Biomedicines 2023-04-09 [PMID: 37189751] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Q Wan, B Huang, T Li, Y Xiao, Y He, W Du, BZ Wang, GF Dakin, M Rosenbaum, MD Goncalves, S Chen, KW Leong, L Qiang Selective targeting of visceral adiposity by polycation nanomedicine Nature nanotechnology, 2022-12-01;0(0):. 2022-12-01 [PMID: 36456644] (Western Blot, Mouse)	Western Blot	Mouse
Ying He, Alana B'nai Taub, Lexiang Yu, Yifan Yao, Ruotong Zhang, Tarik Zahr et al. PPAR gamma Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms Advanced Science 2023-01-01 [PMID: 36394167]
Chan Hee J Choi, William Barr, Samir Zaman, Corey Model, Annsea Park, Mascha Koenen et al. LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation eLife 2022-11-08 [PMID: 36346018]
M Mizuno, B Khaledian, M Maeda, T Hayashi, S Mizuno, E Munetsuna, T Watanabe, S Kono, S Okada, M Suzuki, S Takao, H Minami, N Asai, F Sugiyama, S Takahashi, Y Shimono Adipsin-Dependent Secretion of Hepatocyte Growth Factor Regulates the Adipocyte-Cancer Stem Cell Interaction Cancers, 2021-08-23;13(16):. 2021-08-23 [PMID: 34439392] (Western Blot, Mouse)	Western Blot	Mouse
N Aaron, MJ Kraakman, Q Zhou, Q Liu, S Costa, J Yang, L Liu, L Yu, L Wang, Y He, L Fan, H Hirakawa, L Ding, J Lo, W Wang, B Zhao, E Guo, L Sun, CJ Rosen, L Qiang Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells Elife, 2021-06-22;10(0):. 2021-06-22 [PMID: 34155972] (Western Blot, Mouse)	Western Blot	Mouse
D Pauly, D Agarwal, N Dana, N Schäfer, J Biber, KA Wunderlich, Y Jabri, T Straub, NR Zhang, AK Gautam, BHF Weber, SM Hauck, M Kim, CA Curcio, D Stambolian, M Li, A Grosche Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina Cell Rep, 2019-11-26;29(9):2835-2848.e4. 2019-11-26 [PMID: 31775049] (Western Blot, Mouse)	Western Blot	Mouse
X Wu, I Hutson, AM Akk, S Mascharak, CTN Pham, DE Hourcade, R Brown, JP Atkinson, CA Harris Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy J. Immunol., 2018-03-12;0(0):. 2018-03-12 [PMID: 29531168] (Western Blot, Mouse)	Western Blot	Mouse
Regulation of C3 Activation by the Alternative Complement Pathway in the Mouse Retina PLoS ONE, 2016-08-26;11(8):e0161898. 2016-08-26 [PMID: 27564415] (Western Blot, Mouse)	Western Blot	Mouse
M M Ruseva, M Takahashi, T Fujita, M C Pickering C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo Clinical and Experimental Immunology 2014-03-06 [PMID: 24279761]
Zou , Lin, Feng , Yan, Li , Yan, Zhang , Ming, Chen , Chan, Cai , Jiayan, Gong , Yu, Wang , Larry, Thurman , Joshua M, Wu , Xiaobo, Atkinson , John P, Chao , Wei Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol, 2013-10-23;191(11):5625-35. 2013-10-23 [PMID: 24154627] (Western Blot, Mouse)	Western Blot	Mouse
Show All 13 Publications. Collapse Publications.

Array AF5430

• Complement Factor D/Adipsin Antibodies
• Complement Factor D/Adipsin ELISA Kit
• Complement Factor D/Adipsin ELISAs
• Complement Factor D/Adipsin Proteins and Enzymes