Recombinant Human Annexin A2 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Annexin A2 (ANXA2), also known as Annexin II and Lipocortin II (LPC2), is a 39 kDa member of the Annexin family. Annexins are calcium-dependent phospholipid-binding proteins that are preferentially located on the cytosolic face of the plasma membrane. The Annexins consist of a unique N-terminal domain followed by a homologous C-terminal core domain containing the phospholipid-binding sites. The C-terminal domain is comprised of four 60-70 aa annexin repeats which form a tightly packed disc known as the annexin domain. Members of the Annexin family play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways (1). Annexin A2 is heavily involved in membrane organization and traffic (2). Annexin A2 also functions as an autocrine factor to enhance osteoclast formation and bone resorption and is a major cellular substrate of the tyrosine kinase encoded by the SRC oncogene (3, 4). Human Annexin A2 shares 97% identity with mouse and rat Annexin A2.

Array 9409-AN

• Annexin A2 Antibodies
• Annexin A2 ELISA Kits
• Annexin A2 Lysates
• Annexin A2 Proteins
• Annexin A2 Proteins and Enzyme
• Annexin A2 ELISA