Recombinant Cynomolgus/Rhesus NKG2D Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Natural killer group 2, member D (NKG2D) is a type II lectin-like transmembrane glycoprotein is an activating receptor involved in both innate and adaptive immunities. Cynomologus NKG2D consists of an extracellular domain (ECD) with a C-type lectin domain, a transmembrane segment and a short cytoplasmic domain lacking signaling properties. The ECD lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands (1). The ECD of cynomologus NKG2D shares 98% amino acid sequence identity with the ECD of human NKG2D. NKG2D is expressed on CD8+ alpha beta T cells, gamma δ T cells, NK cells and NKT cells and additionally occurs on macrophages in mouse (1 - 3). The NKG2D receptor consists of a homodimer and has been shown to mediate immune responses and determine the activation status of NK cells (4). In human, ligands for NKG2D include MICA, MICB, and ULBP1, 2, and 3 (3, 5). Expression of NKG2D ligands occurs in epithelial cells, tumor cells and under conditions of stress or infection (6, 7). Alternative splicing of the NKG2D results in isoforms with different cytoplasmic domains that can associate either with DAP12 to deliver a true activating signal or with DAP10 resulting in a costimulatory signal (7). NKG2D has been implicated in anti-tumor surveillance and the immune response against viral infection (6, 8).

Array 10960-NK

• NKG2D/CD314 Antibodies
• NKG2D/CD314 Protein
• NKG2D/CD314 Proteins and Enzymes