Recombinant Cynomolgus/Rhesus Macaque B7-1/CD80 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses (1). Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100-fold higher affinity than CD28 and is involved in the down-regulation of the immune response (2-5). B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells (2). Mature cynomolgus monkey B7-1 consists of a 213 amino acid (aa) extracellular domain (ECD) with two immunoglobulin-like domains, a 22 aa transmembrane domain, and a 20 aa cytoplasmic domain. Within the ECD, cynomolgus monkey B7-1 shares 97% and 51% aa sequence identity with human and mouse B7-1, respectively. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas (6).

Array 9695-B1

• B7-1/CD80 Antibodies
• B7-1/CD80 ELISA Kit
• B7-1/CD80 Proteins
• B7-1/CD80 ELISAs
• B7-1/CD80 Proteins and Enzymes