RAG1 Antibody

As a catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Chemotaxis, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-74190	Applications	Species
Lu Y, Wu Y, Feng X et al. CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis. J. Clin. Invest. 2014-03-10 [PMID: 24614102] (WB, Mouse)	WB	Mouse
Zhou XF, Yu J, Chang M et al. TRIM28 mediates chromatin modifications at the TCRalpha enhancer and regulates the development of T and natural killer T cells Proc Natl Acad Sci U S A 2012-12-04 [PMID: 23169648] (Chemotaxis, Mouse)	Chemotaxis	Mouse

Array NBP1-74190

• RAG1 Antibodies