Rad50 Antibody

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: KD, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-20054	Applications	Species
Feng W, Simpson DA, Cho JE et al. Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks Nucleic acids research 2021-05-21 [PMID: 33963863]
Fagan-Solis KD, Simpson DA, Kumar RJ et al. A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability Cell Rep 2020-02-04 [PMID: 32023457] (WB, KD, Mouse)	WB, KD	Mouse

Array NBP2-20054

• Rad50 Antibodies
• Rad50 ELISA Kits
• Rad50 Protein