PTPN13/PTPL1 Antibody

FAP-1 (also known as Fas-associated phosphatase-1, PTPN13, PTP-BAS, hPTPIE, and PTPL1) is a member of the protein tyrosine phosphatase (PTP) family (reviewed in Meinhold-Heerlein et al, 2001; Savaskan et al, 2005; Foehr et al, 2005; and Ivanov et al, 2006). PTPs are enzymes that catalyze the removal of a phosphate group attached to a tyrosine residue. Most intracellular signaling involves reversible phosphorylation events; therefore, PTPs are central to the dynamic regulation of signaling cascades that underlie cell functions. For example, PTPs play key roles in regulating cell growth, differentiation, proliferation, inflammation, and oncogenic transformation. PTPs are emerging as a promising class of signaling targets for diseases such as cancer, neurodegeneration, diabetes, and inflammation. A key challenge is to identify specific PTPs that are involved in a disease process and develop therapeutics to modulate the PTP. FAP-1 phosphatase is thought to be important in the Fas signaling pathway. FAP-1 binds to the cytosolic tail of the Fas receptor (Apo1, CD95) and inhibits Fas-induced apoptosis. Increased FAP-1 protein levels in some tumor cell lines and tumor tissues correlates with resistance to Fas-mediated apoptosis. In general, FAP-1 expression has been found to be highest in cell lines and tissues that are relatively resistant to Fas-mediated apoptosis. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line which is consistent with an inhibitory effect of FAP-1 on Fas signal transductions. Additionally, FAP-1 expression correlates with Fas resistant in ovarian cancer cell lines and FAP-1 is commonly expression in ovarian cancers. Human Fas has a putative consensus tyrosine phosphorylation site (Tyrosine 275) suggesting that Fas surface expression or signaling may be regulated by phosphorylation. FAP-1 has been shown to directly bind to Fas and may dephosphorylate Fas as part of the down regulation of the apoptotic pathway. It is thought that development of therapeutics to inhibit FAP-1 may increase the ability of tumor cells with upregulated FAP-1 to undergo apoptosis. FAP-1 is a large approx. 270 kDa protein. Multiple alternatively spliced FAP-1 transcript variants which encode distinct proteins have been reported, including shorter forms. Please see Application Notes section for additional details on FAP-1 isoforms.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 5 of 5.

Publications using NB100-56139	Applications	Species
Zhu N, Zhang XJ, Zou H et al. PTPL1 suppresses lung cancer cell migration via inhibiting TGF-beta 1-induced activation of p38 MAPK and Smad 2/3 pathways and EMT Acta pharmacologica Sinica 2021-02-03 [PMID: 33536603]
Sharma S, Carmona A, Skowronek A et al. Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95 Nat Commun 2019-07-15 [PMID: 31308371] (WB, Human)	WB	Human
Lin YT, Wang HC, Hsu YC et al. Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway. Int J Mol Sci. 2017-06-23 [PMID: 28644386] (IF/IHC, Human)	IF/IHC	Human
Banks CA, Boanca G, Lee ZT et al. Proteins interacting with cloning scars: a source of false positive protein-protein interactions Sci Rep 2015-02-23 [PMID: 25704442] (WB, Human)	WB	Human
Meinhold-Heerlein I, Stenner-Liewen F, Liewen H et al. Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer. Am J Pathol. 2001-04-01 [PMID: 11290551]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Human	09/30/2019	View Summary Application Western Blot Sample Tested 293T cell lysate Species Human Lot AR31-07170613-02

Array NB100-56139

• PTPN13/PTPL1 Antibodies
• PTPN13/PTPL1 Proteins