PIK3R4 Antibody (1B5)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 5 of 5.

Publications using H00030849-M02	Applications	Species
Miranda AM, Lasiecka ZM, Xu Y et al. Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures. Nat Commun 2018-01-18 [PMID: 29348617]
Nascimbeni AC, Fanin M, Angelini C, Sandri M. Autophagy dysregulation in Danon disease. Cell Death Dis 2017-01-19 [PMID: 28102838]
Stoetzel C, Bar S, De Craene JO et al. A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi. Nat Commun. 2016-11-24 [PMID: 27882921]
Hirsch DS, Shen Y, Dokmanovic M et al. Insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTOR/S6K1. Cell Signal. 2014-02-27 [PMID: 24582588]
Devereaux K. Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis. PLoS One. 2013-10-03 [PMID: 24098492]

Array H00030849-M02

• PIK3R4 Antibodies
• PIK3R4 Proteins