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PADI4 Antibody [Biotin]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications IHC, ICC/IF (-), WB (-)
Clonality
Polyclonal
Host
Rabbit
Conjugate
Biotin

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PADI4 Antibody [Biotin] Summary

Immunogen
A synthetic peptide made to an internal portion of the human PAD4 protein (between residues 200-250) [UniProt Q9UM07]
Localization
Cytoplasm. Nucleus. Cytoplasmic granule. Note: Cytoplasmic granules of eosinophils and neutrophils.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PADI4
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for PADI4 Antibody [Biotin]

  • HL-60 PAD
  • PAD
  • PAD4
  • PADI4
  • PADI5PADI-H protein
  • PADPAD4
  • PDI4
  • PDI5EC 3.5.3.15
  • peptidyl arginine deiminase, type IV
  • peptidyl arginine deiminase, type V
  • Peptidylarginine deiminase IV
  • Protein-arginine deiminase type IV
  • protein-arginine deiminase type-4

Background

In vivo expression of PADI4 correlated with the appearance of citrulline in histones. We have shown that PADI4 converts arginines in the histone H3 tail to citrulline, that PADI4 blocks transcriptional activation and is recruited to the endogenous promotor. PADI4 represents a novel class of histone modifying enzymes probably linked to eostrogen regulated transcription.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PADI4