NPRA/NPR1 Antibody

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 (PubMed 7982997)). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).(supplied by OMIM)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ELISA, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-31333	Applications	Species
Meng J, Moriyama M et al. New mechanism underlying IL-31-induced atopic dermatitis. J Allergy Clin Immunol 2018-01-05 [PMID: 29427643] (ELISA, Human)	ELISA	Human
Wu W, Shi F et al. Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance. Sci Signal 2017-07-25 [PMID: 28743802] (WB, Mouse)	WB	Mouse
Kovacova Z, Tharp WG, Liu D et al. Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes. Obesity (Silver Spring). 2016-02-17 [PMID: 26887289] (WB, Human) Details: Natriuretic Peptide Receptor C (NPRC) antibody used for WB on human subcutaneous adipose lysates from lean subjects, obese subjects with NGT (normal glucose tolerance), and subjects with T2DM (type 2 diabetes mellitus) (Figure 1C).	WB	Human

Array NBP1-31333

• NPRA/NPR1 Antibodies
• NPRA/NPR1 ELISA Kits
• NPRA/NPR1 Lysate
• NPRA/NPR1 Proteins
• NPRA/NPR1 Proteins and Enzyme