Name: Otx2 Antibody [Biotin]
Brand: Novus Biologicals
SKU: BAF1979
Price: 519 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, ICC/IF
Clonality	Polyclonal
Host	Goat
Conjugate	Biotin
Concentration	LYOPH

Catalog# & Formulation	Size	Price
Standard Formulation AF1979

Carrier Free AF1979

Carrier Free AF1979-SP

Immunogen	E. coli-derived recombinant human Otx2 Met1-Leu289 Accession # P32243
Specificity	Detects human Otx2 in Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	OTX2
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Otx2 Antibody [Biotin]

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Publications for Otx2 Antibody (BAF1979)(38)

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Bioinformatics

Publications using BAF1979	Applications	Species
Tresenrider, A;Hooper, M;Todd, L;Kierney, F;Blasdel, N;Trapnell, C;Reh, TA; A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia bioRxiv : the preprint server for biology 2023-09-27 [PMID: 37808650] (Immunohistochemistry, Transgenic Mouse)	Immunohistochemistry	Transgenic Mouse
Palazzo I, Todd LJ, Hoang TV et al. NFkB-signaling promotes glial reactivity and suppresses M�ller glia-mediated neuron regeneration in the mammalian retina Glia 2022-07-01 [PMID: 35388544]
Palazzo I, Todd LJ, Hoang TV et al. NFkB-signaling promotes glial reactivity and suppresses M�ller glia-mediated neuron regeneration in the mammalian retina Glia 7/1/2022 [PMID: 35388544]
C Finkbeiner, I Ortuño-Liz, A Sridhar, M Hooper, S Petter, TA Reh Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition Cell Reports, 2022-01-25;38(4):110294. 2022-01-25 [PMID: 35081356] (IHC, Human)	IHC	Human
L Todd, MJ Hooper, AK Haugan, C Finkbeiner, N Jorstad, N Radulovich, CK Wong, PC Donaldson, W Jenkins, Q Chen, F Rieke, TA Reh Efficient stimulation of retinal regeneration from Mï¿½ller glia in adult mice using combinations of proneural bHLH transcription factors Cell Reports, 2021-10-19;37(3):109857. 2021-10-19 [PMID: 34686336] (IF, Mouse)	IF	Mouse
Elizabeth S. Fishman, Mikaela Louie, Adam M. Miltner, Simranjeet K. Cheema, Joanna Wong, Nicholas M. Schlaeger et al. MicroRNA Signatures of the Developing Primate Fovea Frontiers in Cell and Developmental Biology 4/8/2021 [PMID: 33898453]
L Todd, C Finkbeiner, CK Wong, MJ Hooper, TA Reh Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice Cell Reports, 2020-12-15;33(11):108507. 2020-12-15 [PMID: 33326790] (Flow Cytometry, IHC, Transgenic Mouse)	Flow Cytometry, IHC	Transgenic Mouse
Noah B. Goodson, Michael A. Kaufman, Ko U. Park, Joseph A. Brzezinski Simultaneous deletion of Prdm1 and Vsx2 enhancers in the retina alters photoreceptor and bipolar cell fate specification, yet differs from deleting both genes Development 3/6/2020 [PMID: 32541005]
NL Jorstad, MS Wilken, L Todd, C Finkbeiner, P Nakamura, N Radulovich, MJ Hooper, A Chitsazan, BA Wilkerson, F Rieke, TA Reh STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina Cell Rep, 2020-02-18;30(7):2195-2208.e5. 2020-02-18 [PMID: 32075759] (IHC, Mouse)	IHC	Mouse
A Sridhar, A Hoshino, CR Finkbeiner, A Chitsazan, L Dai, AK Haugan, KM Eschenbach, DL Jackson, C Trapnell, O Bermingham, I Glass, TA Reh Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures Cell Rep, 2020-02-04;30(5):1644-1659.e4. 2020-02-04 [PMID: 32023475] (IHC, Human)	IHC	Human
B Bosze, MS Moon, R Kageyama, NL Brown Simultaneous requirements for Hes1 in retinal neurogenesis and optic cup-stalk boundary maintenance J. Neurosci., 2020-01-16;0(0):. 1/16/2020 [PMID: 31949107]
A Hoshino, S Horvath, A Sridhar, A Chitsazan, TA Reh Synchrony and asynchrony between an epigenetic clock and developmental timing Sci Rep, 2019-03-06;9(1):3770. 2019-03-06 [PMID: 30842553] (IHC, Human)	IHC	Human
Angelica M. Kowalchuk, Kate A. Maurer, Farnaz Shoja-Taheri, Nadean L. Brown Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis Developmental Biology 10/1/2018 [PMID: 30048641]
Jie Zhu, Deepak A. Lamba Small Molecule-Based Retinal Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells BIO-PROTOCOL 6/20/2018 [PMID: 30009216]
CL Fairchild, K Hino, JS Han, AM Miltner, GP Allina, CE Brown, ME Burns, A La Torre, S Simo RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion Development, 2018-02-02;0(0):. 2018-02-02 [PMID: 29361558] (IHC, Mouse)	IHC	Mouse
Hoshino A, Ratnapriya R, Brooks MJ et al. Molecular Anatomy of the Developing Human Retina. Dev. Cell 12/18/2017 [PMID: 29233477]
PA Nakamura, AA Shimchuk, S Tang, Z Wang, K DeGolier, S Ding, TA Reh Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa Elife, 2017-11-17;6(0):. 11/17/2017 [PMID: 29148976]
TS Mills, T Eliseeva, SM Bersie, G Randazzo, J Nahreini, KU Park, JA Brzezinski Combinatorial regulation of a Blimp1 (Prdm1) enhancer in the mouse retina PLoS ONE, 2017-08-22;12(8):e0176905. 2017-08-22 [PMID: 28829770] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
NL Jorstad, MS Wilken, WN Grimes, SG Wohl, LS VandenBosc, T Yoshimatsu, RO Wong, F Rieke, TA Reh Stimulation of functional neuronal regeneration from Mï¿½ller glia in adult mice Nature, 2017-07-26;548(7665):103-107. 7/26/2017 [PMID: 28746305]
TP Sharma, LA Wiley, SS Whitmore, KR Anfinson, CM Cranston, DJ Oppedal, HT Daggett, RF Mullins, BA Tucker, EM Stone Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa Stem Cell Res, 2017-03-18;21(0):58-70. 2017-03-18 [PMID: 28390992] (ICC, Human)	ICC	Human
A Moshiri, D Humpal, BC Leonard, DM Imai, A Tham, L Bower, D Clary, TM Glaser, KC Lloyd, CJ Murphy Arap1 Deficiency Causes Photoreceptor Degeneration in Mice Invest. Ophthalmol. Vis. Sci, 2017-03-01;58(3):1709-1718. 2017-03-01 [PMID: 28324111] (IHC, Mouse)	IHC	Mouse
KU Park, G Randazzo, KL Jones, JA Brzezinski Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina Invest. Ophthalmol. Vis. Sci, 2017-02-01;58(2):1137-1150. 2017-02-01 [PMID: 28199486] (IHC-Fr, Mouse)	IHC-Fr	Mouse
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness Sci Rep, 2016-07-29;6(0):30742. 2016-07-29 [PMID: 27471043] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Kristan S. Worthington, Luke A. Wiley, C. Allan Guymon, Aliasger K. Salem, Budd A. Tucker Differentiation of Induced Pluripotent Stem Cells to Neural Retinal Precursor Cells on Porous Poly-Lactic-co-Glycolic Acid Scaffolds Journal of Ocular Pharmacology and Therapeutics 6/1/2016 [PMID: 26692377]
Kent W. Small, Adam P. DeLuca, S. Scott Whitmore, Thomas Rosenberg, Rosemary Silva-Garcia, Nitin Udar et al. North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13 Ophthalmology 1/1/2016 [PMID: 26507665]
La Torre A, Hoshino A, Cavanaugh C, Ware C, Reh T The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells. Stem Cells, 2015-06-24;33(9):2674-85. 2015-06-24 [PMID: 26013465] (IHC, Mouse)	IHC	Mouse
Matthew S Wilken, Joseph A Brzezinski, Anna La Torre, Kyle Siebenthall, Robert Thurman, Peter Sabo et al. DNase I hypersensitivity analysis of the mouse brain and retina identifies region-specific regulatory elements Epigenetics & Chromatin 12/1/2015 [PMID: 25972927]
Ueki Y, Wilken M, Cox K, Chipman L, Bermingham-McDonogh O, Reh T A transient wave of BMP signaling in the retina is necessary for Muller glial differentiation. Development, 2015-02-01;142(3):533-43. 2015-02-01 [PMID: 25605781] (IHC, Mouse)	IHC	Mouse
Klimova , Lucie, Kozmik , Zbynek Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development, 2014-02-12;141(6):1292-302. 2014-02-12 [PMID: 24523460] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Kaia Achim, Paula Peltopuro, Laura Lahti, Hui-Hsin Tsai, Alyssa Zachariah, Mia Åstrand et al. The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors Biology Open 10/15/2013 [PMID: 24167708]
Brzezinski J, Uoon Park K, Reh T Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence. Dev Biol, 2013-10-12;384(2):194-204. 2013-10-12 [PMID: 24125957] (IHC-Fr, Immunoprecipitation, Mouse)	IHC-Fr, Immunoprecipitation	Mouse
Tucker B, Anfinson K, Mullins R, Stone E, Young M Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation. Stem Cells Transl Med, 2012-12-27;2(1):16-24. 2012-12-27 [PMID: 23283489] (ICC, Human)	ICC	Human
Achim K, Peltopuro P, Lahti L Distinct developmental origins and regulatory mechanisms for GABAergic neurons associated with dopaminergic nuclei in the ventral mesodiencephalic region. Development, 2012-05-23;139(13):2360-70. 2012-05-23 [PMID: 22627282] (IHC-P, Mouse)	IHC-P	Mouse
Andrew C. McUsic, Deepak A. Lamba, Thomas A. Reh Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds Biomaterials 2/1/2012 [PMID: 22115999]
Joseph A. Brzezinski, Euiseok J. Kim, Jane E. Johnson, Thomas A. Reh Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina Development 8/15/2011 [PMID: 21771810]
Juliane Gust, Thomas A. Reh Adult Donor Rod Photoreceptors Integrate into the Mature Mouse Retina Investigative Opthalmology & Visual Science 7/15/2011 [PMID: 21436277]
Brzezinski JA, Lamba DA, Reh TA Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development, 2010-02-01;137(4):619-29. 2010-02-01 [PMID: 20110327] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Adamson DC, Shi Q, Wortham M OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas. Cancer Res., 2009-12-22;70(1):181-91. 2009-12-22 [PMID: 20028867] (IHC-P, Western Blot, Human, Mouse)	IHC-P, Western Blot	Human, Mouse
Show All 38 Publications. Collapse Publications.

Conjugate	Catalog #	Availability	Size	Price
Unconjugated	AF1979

Gene Symbol	OTX2
Uniprot	P32243()