CRX/CORD2 Antibody (4G11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Chemotaxis, ICC/IF, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry.

Showing Publications 1 - 10 of 32. Show All 32 Publications. Collapse Publications.

Publications using H00001406-M02	Applications	Species
M Langouët, C Jolicoeur, A Javed, P Mattar, MD Gearhart, SP Daiger, M Bertelsen, L Tranebjærg, ND Rendtorff, K Grønskov, C Jespersgaa, R Chen, Z Sun, H Li, N Alirezaie, J Majewski, VJ Bardwell, R Sui, RK Koenekoop, M Cayouette Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration Science Advances, 2022-09-07;8(36):eabh2868. 2022-09-07 [PMID: 36070393]
Dilip R, Masaki I, Yoriko T et al. Evaluation of photoreceptor-directed fibroblasts derived from retinitis pigmentosa patients with defects in the EYS gene: a possible cost-effective cellular model for mechanism-oriented drug. Stem Cell Res Ther. 2022-04-11 [PMID: 35410372]
Xiaoming Z, Bo-Wen Z, Lue X et al. MLL5 is involved in retinal photoreceptor maturation through facilitating CRX-mediated photoreceptor gene transactivation. iScience. 2022-04-15 [PMID: 35359806]
Hunghao C, Ivan R, S B et al. Pigment epithelium-derived factor engineered to increase glycosaminoglycan affinity while maintaining bioactivity. Biochem Biophys Res Commun. 2022-03-17 [PMID: 35334413]
Pin L, Thanh H, Clayton S et al. Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina. Cell Rep. 2021-11-16 [PMID: 34788628]
Yan-Ping L, Wen-Li D, Zi-Bing J et al. Modeling retinitis pigmentosa through patient-derived retinal organoids. STAR Protoc. 2021-06-18 [PMID: 33899019]
Too LK, Shen W, Mammo Z et al. SURGICAL RETINAL EXPLANTS AS A SOURCE OF RETINAL PROGENITOR CELLS Retina 2021-09-01 [PMID: 33560780] (Immunohistochemistry, Immunocytochemistry/ Immunofluorescence)	Immunohistochemistry, Immunocytochemistry/ Immunofluorescence
Hannah D, Julia M, Morgane B et al. Differentiation Protocol for 3D Retinal Organoids, Immunostaining and Signal Quantitation. Curr Protoc Stem Cell Biol. 2020-09-21 [PMID: 32956559]
Mei-Ling G, Xin-Lan L, Fang H et al. Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa. Front Cell Dev Biol. 2020-03-06 [PMID: 32211407]
Garita-Hernandez M, Routet F, Guibbal L et al. AAV-Mediated Gene Delivery to 3D Retinal Organoids Derived from Human Induced Pluripotent Stem Cells. Int J Mol Sci. 2020-02-03 [PMID: 32028585]
Chichagova V, Dorgau B, Felemban M et al. Differentiation of Retinal Organoids from Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2019-09-15 [PMID: 31479596]
Chemla Y, Betzer O, Markus A et al. Gold nanoparticles for multimodal high-resolution imaging of transplanted cells for retinal replacement therapy. Nanomedicine (Lond). 2019-07-24 [PMID: 31339056]
Markus A, Shamul A, Chemla Y et al. An optimized protocol for generating labeled and transplantable photoreceptor precursors from human embryonic stem cells. Exp Eye Res. 2018-11-14 [PMID: 30447199]
Gagliardi G, Ben M'Barek K, Chaffiol A et al. Characterization and Transplantation of CD73-Positive Photoreceptors Isolated from Human iPSC-Derived Retinal Organoids. Stem Cell Reports 2018-08-09 [PMID: 30100409]
Pierre Mattar, Milanka Stevanovic, Ivana Nad, Michel Cayouette Casz1 controls higher-order nuclear organization in rod photoreceptors Proceedings of the National Academy of Sciences of the United States of America 2018-08-21 [PMID: 30072429]
Felemban M, Dorgau B, Hunt NC et al. Extracellular matrix expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix. Acta Biomater 2018-05-17 [PMID: 29777959]
Izuogu OG, Alhasan AA, Mellough C et al. Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular. BMC Genomics 2018-04-20 [PMID: 29678151]
Elsaeidi F, Macpherson P, Mills EA et al. Notch suppression collaborates with Ascl1 and Lin28 to unleash a regenerative response in fish retina, but not in mice. J Neurosci 2018-01-29 [PMID: 29378863]
Lu AQ, Barnstable CJ., et al. Generation of Photoreceptor Precursors from Mouse Embryonic Stem Cells. Stem Cell Rev 2017-10-08 [PMID: 29047024]
Sluch VM, Davis CH, Ranganathan V et al. Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sci Rep 2015-01-01 [PMID: 26563826] (ICC/IF, Human)	ICC/IF	Human
Khan M, Walters LL, Li Q et al. Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma. Lab Invest. 2015-08-17 [PMID: 26280220]
Ohlemacher SK, Iglesias CL, Sridhar A et al. Generation of highly enriched populations of optic vesicle-like retinal cells from human pluripotent stem cells. Curr Protoc Stem Cell Biol 2015-02-02 [PMID: 25640818]
Reichman S, Goureau O. Production of Retinal Cells from Confluent Human iPS Cells. Methods Mol Biol 2016-01-01 [PMID: 25417064]
Xie BB, Zhang XM, Hashimoto T et al. Differentiation of retinal ganglion cells and photoreceptor precursors from mouse induced pluripotent stem cells carrying an atoh7/math5 lineage reporter. PLoS One. 2014-11-17 [PMID: 25401462]
Masuda T, Zhang X, Berlinicke C et al. The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina. J Neurosci. 2014-11-12 [PMID: 25392503] (Chemotaxis, Mouse)	Chemotaxis	Mouse
Reichman S, Terray A, Slembrouck A et al. From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium. Proc Natl Acad Sci U S A. 2014-05-27 [PMID: 24912154]
Tran NM, Zhang A, Zhang X et al. Mechanistically Distinct Mouse Models for CRX-Associated Retinopathy. PLoS Genet. 2014-02-06 [PMID: 24516401]
Jayaram H, Jones MF, Eastlake K et al. Transplantation of photoreceptors derived from human Muller glia restore rod function in the P23H rat. Stem Cells Transl Med. 2014-03-01 [PMID: 24477073]
Carr AJ, Vugler AA, Yu L et al. The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide. Mol Vis. 2011-06-25 [PMID: 21738400]
Sakagami K, Gan L, Yang XJ. Distinct Effects of Hedgehog Signaling on Neuronal Fate Specification and Cell Cycle Progression in the Embryonic Mouse Retina. J Neurosci. 2009-05-27 [PMID: 19474320]
Esumi N, Kachi S, Hackler L Jr et al. BEST1 expression in the retinal pigment epithelium is modulated by OTX family members. Hum Mol Genet;18(1):128-41. 2009-01-01 [PMID: 18849347]
Peng GH, Chen S. Crx activates opsin transcription by recruiting HAT-containing co-activators promoting histone acetylation. Hum Mol Genet;16(20):3433-52. 2007-10-15 [PMID: 17656371]
Show All 32 Publications. Collapse Publications.

Array H00001406-M02

• CRX/CORD2 Antibodies
• CRX/CORD2 Lysate
• CRX/CORD2 Proteins