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OPA1 Antibody (1E8-1D9) [mFluor Violet 450 SE]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, ChHaSpecies Glossary
Applications WB, Simple Western, ICC/IF, IHC
Clone
1E8-1D9
Clonality
Monoclonal
Host
Mouse
Conjugate
mFluor Violet 450 SE

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OPA1 Antibody (1E8-1D9) [mFluor Violet 450 SE] Summary

Immunogen
Human OPA1 [Swiss-Prot# O60313].
Localization
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
OPA1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for OPA1 Antibody (1E8-1D9) [mFluor Violet 450 SE]

  • BERHS
  • EC 3.6.5.5
  • FLJ12460
  • KIAA0567dynamin-like 120 kDa protein, mitochondrial
  • LargeG
  • lilr3
  • MGM1
  • mitochondrial dynamin-like GTPase
  • MTDPS14
  • NPG
  • NPGlargeG
  • NTG
  • NTGmitochondrial dynamin-like 120 kDa protein
  • OPA1
  • optic atrophy 1 (autosomal dominant)
  • Optic atrophy protein 1

Background

OPA1 product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Highly expressed in the retina, OPA1 mutations have been associated with a dominantly inherited optic neuropathy, called optic atrophy type 1, resulting in progressive loss of visual acuity. Eight transcript variants encoding different isoforms, resulting from alternative splicing of exon 4 and two novel exons named 4b and 5b, have been reported for this gene.

OPA1 antibodies are used primarily for vision research.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for OPA1 Antibody (NBP1-71656MFV450) (0)

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Secondary Antibodies

 

Isotype Controls

Additional OPA1 Products

Array NBP1-71656MFV450

Research Areas for OPA1 Antibody (NBP1-71656MFV450)

Find related products by research area.

Blogs on OPA1.

Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease
 By Jamshed Arslan Pharm.D.  Alzheimer's disease (AD) is an irreversible brain disorder that destroys memory and thinking skills. The telltale signs of AD brains are extracellular deposits of amy...  Read full blog post.

BNIP3 - a regulator of mitochondrial autophagy and cell death
Bcl-2 nineteen-kilodalton interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein. BNIP3 localizes to the mitochondrial membrane where it plays a key role in mitochondrial autophagy and cell death pathways. Similar to other Bcl-2 family m...  Read full blog post.

Understanding OPA1 and Mitochondrial Function
OPA1 belongs to the Dynamin large GTPase protein family. OPA1 exists as a single-pass membrane protein localized in the mitochondrial inner membrane and also as a soluble form in the mitochondrial intermembrane space. There, it is a key player in fusi...  Read full blog post.

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Bioinformatics

Gene Symbol OPA1