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Niemann-Pick C1 Antibody (1318A) [Janelia Fluor® 525]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, KO
Clone
1318A
Clonality
Monoclonal
Host
Rabbit
Conjugate
Janelia Fluor 525

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-76798AF350
Alexa Fluor 405
NBP2-76798AF405
Alexa Fluor 488
NBP2-76798AF488
Alexa Fluor 532
NBP2-76798AF532
Alexa Fluor 594
NBP2-76798AF594
Alexa Fluor 647
NBP2-76798AF647
Alexa Fluor 700
NBP2-76798AF700
Alexa Fluor 750
NBP2-76798AF750
Allophycocyanin
NBP2-76798APC
Biotin
NBP2-76798B
CoraFluor 1
NBP2-76798CL1
DyLight 350
NBP2-76798UV
DyLight 405
NBP2-76798V
DyLight 488
NBP2-76798G
DyLight 550
NBP2-76798R
DyLight 594
NBP2-76798DL594
DyLight 650
NBP2-76798C
DyLight 680
NBP2-76798FR
DyLight 755
NBP2-76798IR
FITC
NBP2-76798F
HRP
NBP2-76798H
Janelia Fluor 549
NBP2-76798JF549
Janelia Fluor 585
NBP2-76798JF585
Janelia Fluor 635
NBP2-76798JF635
Janelia Fluor 646
NBP2-76798JF646
Janelia Fluor 669
NBP2-76798JF669
PE
NBP2-76798PE
PerCP
NBP2-76798PCP
Unconjugated
NBP2-76798
mFluor Violet 450 SE
NBP2-76798MFV450
mFluor Violet 500 SE
NBP2-76798MFV500
mFluor Violet 610 SE
NBP2-76798MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-76798
BSA Free
NBP2-76798SS
BSA Free
NBP2-76798
Azide and BSA Free
NBP2-80879
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Niemann-Pick C1 Antibody (1318A) [Janelia Fluor® 525] Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
A synthetic peptide made to the C-terminal region of human Niemann-Pick C. [UniProt# O15118]
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
NPC1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockout Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Niemann-Pick C1 Antibody (1318A) [Janelia Fluor® 525]

  • FLJ98532
  • Niemann-Pick C1 protein
  • Niemann-Pick disease, type C1
  • Niemann-Pick Type C1
  • NPC
  • NPC1
  • SLC65A1

Background

Niemann-Pick type C1 (NPC1) is a member of a family of genes encoding membrane-bound proteins containing putative sterol sensing domains. The protein regulates cholesterol transport from late endosomes-lysosomes to other intracellular compartments. NPC1 overexpression increases both the rate of trafficking of low density lipoprotein cholesterol to the endoplasmic reticulum and the rate of delivery of endosomal cholesterol to the plasma membrane. NPC disease is an inherited neurovisceral lipid storage disorder of unesterified cholesterol accumulation in lysosomes. It is characterized by progressive neural and liver degeneration, resulting from inactivating mutations in NPC1, in most cases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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DBD00
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Niemann-Pick C1
Antibody (1318A) [Jan ...
NBP2-76798JF525
Niemann-Pick C1 Antibody (1318A) [Janelia Fluor® 525]
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, KO

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Niemann-Pick C1 Antibody (NBP2-76798JF525). (Showing 1 - 1 of 1 FAQ).

  1. I'm looking for a Niemann-Pick type1 or 2 antibody to stain mouse heart section embedded in paraffin. I would like to label these sections with another primary antibody to show colocalisation of my protein of interest. I would like to know if you have a rabbit anti-Niemann-Pick antibody that works well for fluorescence immunohistochemistry?
    • Niemann-Pick C1 Antibody (<a href="http://www.novusbio.com/NB400-148" target="_self">NB400-148</a>) (0.1 ml) is one of our best sellers and this antibody has been cited in at least 17 peer reviewed research publications in journals of high repute. We have only one Niemann-Pick type C2 antibody with catalog # <a href="http://www.novusbio.com/H00010577-D01P" target="_self">H00010577-D01P</a>, but this antibody is yet to be established for IHC application. However, if you would like to try this antibody for IHC-P application you would qualify for our Innovators Reward program. Through this program if you complete an online review with image, detailing your positive or negative results we will send you a discount voucher for 100% of the purchase price of the reviewed product. Read more about <a href="http://www.novusbio.com/support/innovators-reward.html" target="_self">Innovators Reward Program</a>.

Secondary Antibodies

 

Isotype Controls

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By Natalia Gurule, PhD Breast Cancer is a Heterogeneous DiseaseBreast cancer is the most frequently identified malignancy in women, accounting for 30% of diagnosed cases of cancer in women in the US annuall...  Read full blog post.
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Bioinformatics

Gene Symbol NPC1