NCAM-1/CD56 Antibody (SPM128)

NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig) like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins. NCAM is expressed on most neuroectodermal derived cell lines, tissues and neoplasm such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NBP2-34349	Applications	Species
Sundberg M, Pinson H, Smith RS et al. 16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro Nat Commun 2021-05-19 [PMID: 34006844] Details: Citation using the Azide and BSA Free format of this antibody.

Array NBP2-34349

• NCAM-1/CD56 Antibodies
• NCAM-1/CD56 ELISA Kits
• NCAM-1/CD56 Lysate
• NCAM-1/CD56 Proteins
• NCAM-1/CD56 ELISA
• NCAM-1/CD56 Proteins and Enzymes