NBR1 Antibody [Biotin]

NBR1 is a cargo receptor that sequesters ubiquinated proteins in the same manner as p62/SQSTM1, which leads to selective autophagy, sequestering the proteins into autophagomes. Both NBR1 and p62 localize to the endoplasmic reticulum independently of LC3. When the ability of cells to induce autophagy is impaired, aggregation of ubiquinated proteins occurs, and causes certain diseases. Particularly in neurodegenerative diseases, the functionality of NBR1 is adversely affected, which is related to the formation of protein aggregations within the brain. Analysis of the location and abundance of NBR1 in tissues can be a good indicator of autophagic failure and disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-71703B

• NBR1 Antibodies
• NBR1 Lysates
• NBR1 Proteins