BAF180/PB1 Antibody

The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. PB1/BAF180 is a component of the SWI/SNF-B (PBAF) complex. It contains six bromodomains which are defined by a 110 amino-acid module that interacts with acetylated lysine and is found in many chromatin binding proteins and histone acetyltransferases. PB1/BAF180 has been proposed to function as a tumor suppressor protein. Recently, PB1/BAF180 has been found to play a role in mediating cell cycle arrest in response to DNA damage via the regulation of the tumor suppressor p21. Alternate names for PB1/BAF180 include protein polybromo-1, polybromo-1D, BRG1-associated factor 180, hPB1, and PBRM1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IF/IHC, IHC-Fr, WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-79833	Applications	Species
Chen W, Pilling D, Gomer RH The mRNA binding protein DDX3 mediates TGF-?1 upregulation of translation and promotes pulmonary fibrosis JCI insight 2023-02-23 [PMID: 36821384] (WB, IHC-Fr, Human, Mouse)	WB, IHC-Fr	Human, Mouse
Murakami A, Wang L, Kalhorn S et al. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma Oncogenesis 2017-01-16 [PMID: 28092369] (WB, IF/IHC, Human)	WB, IF/IHC	Human
Paw?owski R, Muhl SM, Sulser T et al. Loss of PBRM1 expression is associated with renal cell carcinoma progression. Int J Cancer 2013-01-01 [PMID: 22949125]
Burrows AE, Smogorzewska A, Elledge SJ et al. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc Natl Acad Sci U S A 2010-08-01 [PMID: 20660729]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Pramod Mallikarjuna	WB	Human	08/30/2014	View Summary Application Western Blot Sample Tested Clear cell renal cell carcinoma samples Species Human

Array NB100-79833

• BAF180/PB1 Antibodies
• BAF180/PB1 Lysate
• BAF180/PB1 Proteins