mtTFA Antibody

This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Mouse, Rat, Rabbit.

We have publications tested in 3 applications: B/N, IF/IHC, WB.

Showing Publications 1 - 8 of 8.

Publications using NBP2-19437	Applications	Species
Song Y, Yuan M, Zhang Z et al. Metformin protects diabetes-induced atrial mitochondrial from oxidative stress and improves mitochondrial biogenesis via the AMPK signaling pathway Research Square 2023-06-26 (WB, Rat)	WB	Rat
Vijayan M, Reddy PH Reduced VDAC1, Maintained Mitochondrial Dynamics and Enhanced Mitochondrial Biogenesis in a Transgenic Tau Mouse Model of Alzheimer's Disease International journal of molecular sciences 2022-08-02 [PMID: 35955694] (IF/IHC, Mouse) Details: WB dilution used 1:1000, IHC dilution used 1:102	IF/IHC	Mouse
Li X, Flynn ER, do Carmo JM et al. Direct Cardiac Actions of Sodium-Glucose Cotransporter 2 Inhibition Improve Mitochondrial Function and Attenuate Oxidative Stress in Pressure Overload-Induced Heart Failure Frontiers in Cardiovascular Medicine 2022-05-12 [PMID: 35647080] (B/N)	B/N
Huang Q, Wu D, Zhao J et al. TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis The EMBO journal [PMID: 35451091]
Zhang Z, Zhang X, Meng L et al. Pioglitazone Inhibits Diabetes-Induced Atrial Mitochondrial Oxidative Stress and Improves Mitochondrial Biogenesis, Dynamics, and Function Through the PPAR-gamma/PGC-1 alpha Signaling Pathway Frontiers in Pharmacology 2021-06-14 [PMID: 34194324] (WB)	WB
Yamanishi, K;Doe, N;Mukai, K;Ikubo, K;Hashimoto, T;Uwa, N;Sumida, M;El-Darawish, Y;Gamachi, N;Li, W;Kuwahara-Otani, S;Maeda, S;Watanabe, Y;Hayakawa, T;Yamanishi, H;Matsuyama, T;Yagi, H;Okamura, H;Matsunaga, H; Interleukin-18-deficient mice develop hippocampal abnormalities related to possible depressive-like behaviors Neuroscience 2019-04-11 [PMID: 30981863] (WB, Mouse)	WB	Mouse
Manczak M, Kandimalla R, Yin X, Hemachandra Reddy P. Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity. Hum. Mol. Genet. 2018-09-19 [PMID: 30239719] (WB, Mouse)	WB	Mouse
Yang Y, Zhao J et al. Xanthine Oxidase Inhibitor Allopurinol Prevents Oxidative Stress-Mediated Atrial Remodeling in Alloxan-Induced Diabetes Mellitus Rabbits. J Am Heart Assoc 2018-02-05 [PMID: 29720500] (WB, Rabbit, Mouse)	WB	Rabbit, Mouse

Array NBP2-19437

• mtTFA Antibodies
• mtTFA Lysate
• mtTFA Proteins