Mouse M-CSF Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

M-CSF, also known as CSF-1, is a four-alpha-helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. M-CSF is also essential for the survival and proliferation of osteoclast progenitors. M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis. M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta. Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells. The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur. Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF can circulate, it may be immobilized by attachment to type V collagen. Shorter transcripts encode M-CSF that lack cleavage and PG sites and produce an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer. Although forms may vary in activity and half-life, all contain the N-terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor. The first 223 aa of mature human M-CSF shares 88%, 86%, 81% and 74% aa identity with corresponding regions of dog, cow, mouse and rat M-CSF, respectively. Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 10 of 34. Show All 34 Publications. Collapse Publications.

Publications using MMC00B	Applications	Species
Takacs, GP;Garcia, JS;Hodges, CA;Kreiger, CJ;Sherman, A;Harrison, JK; Glioma-derived M-CSF and IL-34 license M-MDSCs to suppress CD8+ T cells in a NOS-dependent manner bioRxiv : the preprint server for biology 2024-06-06 [PMID: 38895268] (Mouse)		Mouse
Katoku-Kikyo, N;Lim, S;Yuan, C;Koroth, J;Nakagawa, Y;Bradley, EW;Kikyo, N; The circadian regulator PER1 promotes cell reprogramming by inhibiting inflammatory signaling from macrophages PLoS biology 2023-12-04 [PMID: 38048364] (Mouse)		Mouse
YC Teh, MY Chooi, D Liu, I Kwok, GC Lai, L Ayub Ow Yo, M Ng, JLY Li, Y Tan, M Evrard, L Tan, KH Liong, K Leong, CC Goh, AYJ Chan, NB Shadan, CK Mantri, YY Hwang, H Cheng, T Cheng, W Yu, HL Tey, A Larbi, A St John, V Angeli, C Ruedl, B Lee, F Ginhoux, SL Chen, LG Ng, JL Ding, SZ Chong Transitional premonocytes emerge in the periphery for host defense against bacterial infections Science Advances, 2022-03-04;8(9):eabj4641. 2022-03-04 [PMID: 35245124] (Mouse)		Mouse
JG Noel, SW Ramser, L Pitstick, JP Bonamer, B Mackenzie, KG Seu, TA Kalfa, JA Cancelas, JC Gardner M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling Scientific Reports, 2022-01-24;12(1):1235. 2022-01-24 [PMID: 35075211] (Mouse)		Mouse
OJ Kwon, B Zhang, D Jia, L Zhang, X Wei, Z Zhou, D Liu, KT Huynh, K Zhang, Y Zhang, P Labhart, A Sboner, C Barbieri, MC Haffner, CJ Creighton, L Xin Elevated expression of the colony-stimulating factor 1 (CSF1) induces prostatic intraepithelial neoplasia dependent of epithelial-Gp130 Oncogene, 2022-01-08;0(0):. 2022-01-08 [PMID: 34999736] (Mouse)		Mouse
W Li, X Zhang, C Zhang, J Yan, X Hou, S Du, C Zeng, W Zhao, B Deng, DW McComb, Y Zhang, DD Kang, J Li, WE Carson, Y Dong Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy Nature Communications, 2021-12-14;12(1):7264. 2021-12-14 [PMID: 34907171] (Mouse)		Mouse
AM La Rose, V Bazioti, JA Hoogerland, AF Svendsen, AG Groenen, M van Faasse, MGS Rutten, NJ Kloosterhu, B Dethmers-A, JH Nijland, G Mithieux, F Rajas, F Kuipers, MV Lukens, O Soehnlein, MH Oosterveer, M Westerterp Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia Molecular Metabolism, 2021-06-04;53(0):101265. 2021-06-04 [PMID: 34091064] (Mouse)		Mouse
R Samain, A Brunel, T Douché, M Fanjul, S Cassant-So, J Rochotte, J Cros, C Neuzillet, J Raffenne, C Duluc, A Perraud, J Nigri, V Gigoux, I Bieche, M Ponzo, G Carpentier, I Cascone, R Tomasini, HA Schmid, M Mathonnet, R Nicolle, MP Bousquet, Y Martineau, S Pyronnet, C Jean, C Bousquet Pharmacological normalization of pancreatic cancer-associated fibroblast secretome impairs pro-metastatic cross-talk with macrophages: Stromal CSF-1 facilitates metastasis Cellular and Molecular Gastroenterology and Hepatology, 2021-01-20;0(0):. 2021-01-20 [PMID: 33482394] (Mouse)		Mouse
M Song, OO Yeku, S Rafiq, T Purdon, X Dong, L Zhu, T Zhang, H Wang, Z Yu, J Mai, H Shen, B Nixon, M Li, RJ Brentjens, X Ma Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages Nature Communications, 2020-12-08;11(1):6298. 2020-12-08 [PMID: 33293516] (Mouse)		Mouse
N Hagan, JL Kane, D Grover, L Woodworth, C Madore, J Saleh, J Sancho, J Liu, Y Li, J Proto, M Zelic, A Mahan, M Kothe, AA Scholte, M Fitzgerald, B Gisevius, A Haghikia, O Butovsky, D Ofengeim CSF1R signaling is a regulator of pathogenesis in progressive MS Cell Death Dis, 2020-10-23;11(10):904. 2020-10-23 [PMID: 33097690] (Mouse)		Mouse
M Hetzel, E Lopez-Rodr, A Mucci, AHH Nguyen, T Suzuki, K Shima, T Buchegger, S Dettmer, T Rodt, JP Bankstahl, P Malik, L Knudsen, A Schambach, G Hansen, BC Trapnell, N Lachmann, T Moritz Effective hematopoietic stem cell-based gene therapy in a murine model of hereditary pulmonary alveolar proteinosis Haematologica, 2019-07-09;105(4):1147-1157. 2019-07-09 [PMID: 31289207] (Mouse)		Mouse
S Ivanov, A Gallerand, M Gros, MI Stunault, J Merlin, N Vaillant, L Yvan-Charv, RR Guinamard Mesothelial cell CSF1 sustains peritoneal macrophage proliferation Eur. J. Immunol., 2019-07-05;0(0):. 2019-07-05 [PMID: 31251389] (Mouse)		Mouse
J Kang, YJ Choi, BY Seo, U Jo, SI Park, YH Kim, KH Park A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment Sci Rep, 2019-06-19;9(1):8726. 2019-06-19 [PMID: 31217507] (Mouse)		Mouse
V Quaranta, C Rainer, SR Nielsen, ML Raymant, MS Ahmed, DD Engle, A Taylor, T Murray, F Campbell, DH Palmer, DA Tuveson, A Mielgo, MC Schmid Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer Cancer Res., 2018-05-22;0(0):. 2018-05-22 [PMID: 29789416] (Mouse)		Mouse
MR Mamedov, A Scholzen, RV Nair, K Cumnock, JA Kenkel, JHM Oliveira, DL Trujillo, N Saligrama, Y Zhang, F Rubelt, DS Schneider, YH Chien, RW Sauerwein, MM Davis A Macrophage Colony-Stimulating Factor-Producing ?? T Cell Subset Prevents Malarial Parasitemic Recurrence Immunity, 2018-02-06;0(0):. 2018-02-06 [PMID: 29426701] (Mouse)		Mouse
X Zhou, RA Franklin, M Adler, JB Jacox, W Bailis, JA Shyer, RA Flavell, A Mayo, U Alon, R Medzhitov Circuit Design Features of a Stable Two-Cell System Cell, 2018-02-01;172(4):744-757.e17. 2018-02-01 [PMID: 29398113] (Mouse)		Mouse
W Lu, D Jia, S An, M Mu, X Qiao, Y Liu, X Li, D Wang Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling Sci Rep, 2017-08-21;7(1):8402. 2017-08-21 [PMID: 28827748] (Mouse)		Mouse
iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice Eur J Immunol, 2016-09-28;0(0):. 2016-09-28 [PMID: 27601030] (Mouse)		Mouse
Monocyte/macrophage lineage commitment and distribution are affected by the lack of regulatory T cells in scurfy mice Eur J Immunol, 2016-05-27;0(0):. 2016-05-27 [PMID: 27130185] (Mouse)		Mouse
Iyer S, Brooks R, Gumbleton M, Kerr W SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging. Stem Cells Dev, 2015-02-05;24(9):1073-81. 2015-02-05 [PMID: 25525673] (Mouse)		Mouse
Liu Q, Tan Q, Zheng Y, Chen K, Qian C, Li N, Wang Q, Cao X Blockade of Fas signaling in breast cancer cells suppresses tumor growth and metastasis via disruption of Fas signaling-initiated cancer-related inflammation. J Biol Chem, 2014-03-13;289(16):11522-35. 2014-03-13 [PMID: 24627480] (Mouse)		Mouse
Cavnar , Michael, Zeng , Shan, Kim , Teresa S, Sorenson , Eric C, Ocuin , Lee M, Balachandran , Vinod P, Seifert , Adrian M, Greer , Jonathan, Popow , Rachel, Crawley , Megan H, Cohen , Noah A, Green , Benjamin, Rossi , Ferdinan, Besmer , Peter, Antonescu , Cristina, DeMatteo , Ronald P KIT oncogene inhibition drives intratumoral macrophage M2 polarization. J Exp Med, 2013-12-09;210(13):2873-86. 2013-12-09 [PMID: 24323358] (Mouse)		Mouse
Bugl S, Wirths S, Radsak M, Schild H, Stein P, Andre M, Muller M, Malenke E, Wiesner T, Marklin M, Frick J, Handgretinger R, Rammensee H, Kanz L, Kopp H Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood, 2012-12-05;121(5):723-33. 2012-12-05 [PMID: 23223360] (Mouse)		Mouse
Tran , Kim, Risingsong , Renee, Royce , Darlene, Williams , Charlott, Sporn , Michael, Pioli , Patricia, Gediya , Lalji K, Njar , Vincent, Liby , Karen T The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer. Carcinogenesis, 2012-10-06;34(1):199-210. 2012-10-06 [PMID: 23042302] (Mouse)		Mouse
Miyamoto K, Yoshida S, Kawasumi M Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J. Exp. Med., 2011-10-17;208(11):2175-81. 2011-10-17 [PMID: 22006978] (Mouse)		Mouse
Timmons BC, Fairhurst AM, Mahendroo MS Temporal changes in myeloid cells in the cervix during pregnancy and parturition. J. Immunol., 2009-03-01;182(5):2700-7. 2009-03-01 [PMID: 19234164] (Mouse)		Mouse
Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs. Arthritis Rheum., 2008-11-01;58(11):3510-9. 2008-11-01 [PMID: 18975342] (Mouse)		Mouse
Islam S, Hassan F, Tumurkhuu G, Dagvadorj J, Koide N, Naiki Y, Mori I, Yoshida T, Yokochi T Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cells. Biochem. Biophys. Res. Commun., 2007-06-12;360(2):346-51. 2007-06-12 [PMID: 17597583] (Mouse)		Mouse
Aiello FB, Keller JR, Klarmann KD, Dranoff G, Mazzucchelli R, Durum SK IL-7 induces myelopoiesis and erythropoiesis. J. Immunol., 2007-02-01;178(3):1553-63. 2007-02-01 [PMID: 17237404] (Mouse)		Mouse
Ghosh-Choudhury N, Singha PK, Woodruff K, St Clair P, Bsoul S, Werner SL, Choudhury GG Concerted action of Smad and CREB-binding protein regulates bone morphogenetic protein-2-stimulated osteoblastic colony-stimulating factor-1 expression. J. Biol. Chem., 2006-05-17;281(29):20160-70. 2006-05-17 [PMID: 16707491] (Mouse)		Mouse
Storm P, Bartholdy C, Sorensen MR, Christensen JP, Thomsen AR Perforin-deficient CD8+ T cells mediate fatal lymphocytic choriomeningitis despite impaired cytokine production. J. Virol., 2006-02-01;80(3):1222-30. 2006-02-01 [PMID: 16414999] (Mouse)		Mouse
Ovadia S, Insogna K, Yao GQ The cell-surface isoform of colony stimulating factor 1 (CSF1) restores but does not completely normalize fecundity in CSF1-deficient mice. Biol. Reprod., 2005-10-19;74(2):331-6. 2005-10-19 [PMID: 16237150] (Mouse)		Mouse
Sergejeva S, Ivanov S, Lotvall J, Linden A Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation. Am. J. Respir. Cell Mol. Biol., 2005-05-18;33(3):248-53. 2005-05-18 [PMID: 15901616] (Mouse)		Mouse
Traynor TR, Herring AC, Dorf ME, Kuziel WA, Toews GB, Huffnagle GB Differential roles of CC chemokine ligand 2/monocyte chemotactic protein-1 and CCR2 in the development of T1 immunity. J. Immunol., 2002-05-01;168(9):4659-66. 2002-05-01 [PMID: 11971015] (Mouse)		Mouse
Show All 34 Publications. Collapse Publications.

Array MMC00B

• M-CSF Antibodies
• M-CSF Antibody Pair
• M-CSF ELISA Kits
• M-CSF Lysates
• M-CSF Proteins
• M-CSF ELISAs
• M-CSF Proteins and Enzymes