Mouse M-CSF DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

M-CSF, also known as CSF-1, is a four-alpha-helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. M-CSF is also essential for the survival and proliferation of osteoclast progenitors. M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis. M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta. Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells. The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur. Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF can circulate, it may be immobilized by attachment to type V collagen. Shorter transcripts encode M-CSF that lack cleavage and PG sites and produce an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer. Although forms may vary in activity and half-life, all contain the N-terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor. The first 223 aa of mature human M-CSF shares 88%, 86%, 81% and 74% aa identity with corresponding regions of dog, cow, mouse and rat M-CSF, respectively. Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 10.

Publications using DY416	Applications	Species
Caronni, N;La Terza, F;Vittoria, FM;Barbiera, G;Mezzanzanica, L;Cuzzola, V;Barresi, S;Pellegatta, M;Canevazzi, P;Dunsmore, G;Leonardi, C;Montaldo, E;Lusito, E;Dugnani, E;Citro, A;Ng, MSF;Schiavo Lena, M;Drago, D;Andolfo, A;Brugiapaglia, S;Scagliotti, A;Mortellaro, A;Corbo, V;Liu, Z;Mondino, A;Dellabona, P;Piemonti, L;Taveggia, C;Doglioni, C;Cappello, P;Novelli, F;Iannacone, M;Ng, LG;Ginhoux, F;Crippa, S;Falconi, M;Bonini, C;Naldini, L;Genua, M;Ostuni, R; IL-1?+ macrophages fuel pathogenic inflammation in pancreatic cancer Nature 2023-11-01 [PMID: 37914939] (Mouse)		Mouse
N Ikeda, H Kubota, R Suzuki, M Morita, A Yoshimura, Y Osada, K Kishida, D Kitamura, A Iwata, S Yotsumoto, D Kurotaki, K Nishimura, A Nishiyama, T Tamura, T Kamatani, T Tsunoda, M Murakawa, Y Asahina, Y Hayashi, H Harada, Y Harada, A Yokota, H Hirai, T Seki, M Kuwahara, M Yamashita, S Shichino, M Tanaka, K Asano The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis Cell Reports, 2023-02-28;42(3):112165. 2023-02-28 [PMID: 36862552] (Mouse)		Mouse
B Khaleel, E Lunenfeld, J Kapelushni, M Huleihel Effect of Chemotherapy Cytarabine and Acute Myeloid Leukemia on the Development of Spermatogenesis at the Adult Age of Immature Treated Mice International Journal of Molecular Sciences, 2022-04-04;23(7):. 2022-04-04 [PMID: 35409373] (Human)		Human
AW Pountain, SK Weidt, C Regnault, PA Bates, AM Donachie, NJ Dickens, MP Barrett Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites PLoS Negl Trop Dis, 2019-02-04;13(2):e0007052. 2019-02-04 [PMID: 30716073] (Mouse)		Mouse
LE Hand, SH Dickson, AJ Freemont, DW Ray, JE Gibbs The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis Arthritis Res. Ther., 2019-01-06;21(1):5. 2019-01-06 [PMID: 30612576] (Mouse)		Mouse
M-CSF Mediates Host Defense during Bacterial Pneumonia by Promoting the Survival of Lung and Liver Mononuclear Phagocytes J Immunol, 2016-05-04;0(0):. 2016-05-04 [PMID: 27183631] (Mouse)		Mouse
Wu K, Byers D, Jin X, Agapov E, Alexander-Brett J, Patel A, Cella M, Gilfilan S, Colonna M, Kober D, Brett T, Holtzman M TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med, 2015-04-20;212(5):681-97. 2015-04-20 [PMID: 25897174] (Mouse)		Mouse
Escamilla J, Schokrpur S, Liu C, Priceman S, Moughon D, Jiang Z, Pouliot F, Magyar C, Sung J, Xu J, Deng G, West B, Bollag G, Fradet Y, Lacombe L, Jung M, Huang J, Wu L CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy. Cancer Res, 2015-03-03;75(6):950-62. 2015-03-03 [PMID: 25736687] (Mouse)		Mouse
Serezani CH, Kane S, Collins L Macrophage Dectin-1 Expression Is Controlled by Leukotriene B4 via a GM-CSF/PU.1 Axis. J. Immunol., 2012-06-13;189(2):906-15. 2012-06-13 [PMID: 22696442] (Mouse)		Mouse
Chuquimia OD, Petursdottir DH, Rahman MJ, Hartl K, Singh M, Fernandez C The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems. PLoS ONE, 2012-02-29;7(2):e32125. 2012-02-29 [PMID: 22393384] (Mouse)		Mouse

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