Mouse IGFBP-3 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. ALS increases the half-life of IGF/IGFBP complexes in circulation.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using MGB300	Applications	Species
F D'Addio, A Maestroni, E Assi, M Ben Nasr, G Amabile, V Usuelli, C Loretelli, F Bertuzzi, B Antonioli, F Cardarelli, B El Essawy, A Solini, IC Gerling, C Bianchi, G Becchi, S Mazzucchel, D Corradi, GP Fadini, D Foschi, JF Markmann, E Orsi, J Škrha, MG Camboni, R Abdi, AM James Shap, F Folli, J Ludvigsson, S Del Prato, G Zuccotti, P Fiorina The IGFBP3/TMEM219 pathway regulates beta cell homeostasis Nature Communications, 2022-02-03;13(1):684. 2022-02-03 [PMID: 35115561] (Mouse)		Mouse
KC Sia, SU Gan, SH Mohd Rodhi, ZY Fu, JJ Kopchick, MJ Waters, KO Lee First use of gene therapy to treat growth hormone resistant dwarfism in a mouse model Gene Therapy, 2022-02-01;0(0):. 2022-02-01 [PMID: 35105948] (Mouse)		Mouse
AM Thiebaut, I Buendia, V Ginet, E Lemarchand, MB Boudjadja, Y Hommet, L Lebouvier, C Lechevalli, M Maillasson, E Hedou, N Déglon, F Oury, M Rubio, J Montaner, J Puyal, D Vivien, BD Roussel Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia Autophagy, 2021-09-14;0(0):1-21. 2021-09-14 [PMID: 34520334] (Mouse)		Mouse
JA Seo, MC Kang, WM Yang, WM Hwang, SS Kim, SH Hong, JI Heo, A Vijyakumar, L Pereira de, A Uner, H Huang, SH Lee, IS Lima, KS Park, MS Kim, Y Dagon, TE Willnow, V Aroda, TP Ciaraldi, RR Henry, YB Kim Apolipoprotein�J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity Nat Commun, 2020-04-24;11(1):2024. 2020-04-24 [PMID: 32332780] (Mouse)		Mouse
J Lu, L Lu, Y Yu, J Cluette-Br, CR Martin, EC Claud Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice Sci Rep, 2018-04-03;8(1):5443. 2018-04-03 [PMID: 29615691] (Mouse)		Mouse
M Linder, M Hecking, E Glitzner, K Zwerina, M Holcmann, L Bakiri, MG Ruocco, J Tuckermann, G Schett, EF Wagner, M Sibilia EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation Cell Death Differ., 2018-02-14;0(0):. 2018-02-14 [PMID: 29445126] (Mouse)		Mouse
Nguyen K, Yao X, Erickson A, Mishra S, Nyomba B Glucose intolerance in aging male IGFBP-3 transgenic mice: differential effects of human IGFBP-3 and its mutant IGFBP-3 devoid of IGF binding ability. Endocrinology, 2014-12-09;156(2):462-74. 2014-12-09 [PMID: 25490144] (Mouse)		Mouse
Eren M, Boe A, Murphy S, Place A, Nagpal V, Morales-Nebreda L, Urich D, Quaggin S, Budinger G, Mutlu G, Miyata T, Vaughan D PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc Natl Acad Sci U S A, 2014-04-28;111(19):7090-5. 2014-04-28 [PMID: 24778222] (Mouse)		Mouse
Lloyd J, Masko E, Wu C, Keenan M, Pilla D, Aronson W, Chi J, Freedland S Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression. Prostate Cancer Prostatic Dis, 2013-07-23;16(4):285-91. 2013-07-23 [PMID: 23877027] (Mouse)		Mouse
Pierroz DD, Bonnet N, Bianchi EN, Bouxsein ML, Baldock PA, Rizzoli R, Ferrari SL Deletion of beta-adrenergic receptor 1, 2, or both leads to different bone phenotypes and response to mechanical stimulation. J. Bone Miner. Res., 2012-06-01;27(6):1252-62. 2012-06-01 [PMID: 22407956] (Mouse)		Mouse
De Lorenzo M, Baljinnyam E, Vatner D, Abarzua P, Vatner S, Rabson A Caloric restriction reduces growth of mammary tumors and metastases. Carcinogenesis, 2011-06-10;32(9):1381-7. 2011-06-10 [PMID: 21665891] (Mouse)		Mouse
Callewaert F, Venken K, Kopchick JJ, Torcasio A, van Lenthe GH, Boonen S, Vanderschueren D Sexual dimorphism in cortical bone size and strength but not density is determined by independent and time-specific actions of sex steroids and IGF-1: evidence from pubertal mouse models. J. Bone Miner. Res., 2010-03-01;25(3):617-26. 2010-03-01 [PMID: 19888832] (Mouse)		Mouse
Show All 12 Publications. Collapse Publications.

Array MGB300

• IGFBP-3 Antibodies
• IGFBP-3 Antibody Pair
• IGFBP-3 ELISA Kits
• IGFBP-3 Lysate
• IGFBP-3 Protein
• IGFBP-3 Proteins and Enzymes
• IGFBP-3 ELISAs