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Mouse CX3CL1/Fractalkine Quantikine ELISA Kit

 (11 Publications)
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Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Mouse CX3CL1/Fractalkine Quantikine ELISA Kit Summary

Background
The Quantikine Mouse Fractalkine Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse Fractalkine in cell culture supernates, tissue homogenates, mouse serum, and plasma. It contains E. coli-expressed recombinant mouse Fractalkine chemokine domain and antibodies raised against the recombinant protein. Results obtained for naturally occurring soluble mouse Fractalkin...e containing the chemokine domain and the mucin stalk domain showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse Fractalkine.
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Specificity
Natural and recombinant mouse Fractalkine (chemokine and extracellular domains)
Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Cx3cl1

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using MCX310.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CX3CL1/Fractalkine Quantikine ELISA Kit

  • ABCD-3
  • C3Xkine
  • chemokine (C-X3-C motif) ligand 1
  • CX3C membrane-anchored chemokine
  • CX3CL1
  • CXC3
  • CXC3C
  • FKN
  • Fractalkine
  • Neurotactin
  • neurotactin)
  • NTNsmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine
  • NTTSmall-inducible cytokine D1
  • SCYD1C-X3-C motif chemokine 1
  • small inducible cytokine subfamily D (Cys-X3-Cys), member-1

Background

CX3CL1/Fractalkine is a transmembrane adhesion protein with a chemokine domain separated from the membrane by a mucin stalk. It is upregulated on many cell types during inflammation. The chemokine and mucin regions can be shed as a soluble chemokine that signals through the receptor CX3CR1. During extravasation, membrane-bound CX3CL1 traps leukocytes, then is cleaved to allow diapedesis. Soluble CX3CL1 protects neurons from microglial neurotoxicity, recruits macrophages for wound healing, recruits osteoclast precursors for bone resorption, and contributes to pathogenesis in coronary artery disease.

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Mouse
CX3CL1/Fractalkine Qu ...
MCX310
Mouse CX3CL1/Fractalkine Quantikine ELISA Kit
Species: Mu
Applications: ELISA
⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CX3CL1/Fractalkine (MCX310)(11)

We have publications tested in 2 confirmed species: Mouse, Rat.


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Mouse
(10)
Rat
(1)
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Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using MCX310 Applications Species
K Inoue, H Morimoto, M Ohgidani, T Ueki Modulation of inflammatory responses by fractalkine signaling in microglia PLoS ONE, 2021-05-21;16(5):e0252118. 2021-05-21 [PMID: 34019594] (Mouse) Mouse
A Helmke, AM Hüsing, S Gaedcke, N Brauns, MS Balzer, M Reinhardt, M Hiss, N Shushakova, D de Luca, I Prinz, H Haller, S von Vietin Peritoneal dialysate-range hypertonic glucose promotes T cell IL-17 production that induces mesothelial inflammation Eur. J. Immunol., 2020-09-30;0(0):. 2020-09-30 [PMID: 32926407] (Mouse) Mouse
R Fu, H Guo, S Janga, M Choi, W Klinngam, MC Edman, SF Hamm-Alvar Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sj�gren's syndrome murine model Sci Rep, 2020-01-29;10(1):1455. 2020-01-29 [PMID: 31996771] (Mouse) Mouse
MD Dorfman, JE Krull, JD Douglass, R Fasnacht, F Lara-Lince, TH Meek, X Shi, V Damian, HT Nguyen, ME Matsen, GJ Morton, JP Thaler Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice Nat Commun, 2017-02-22;8(0):14556. 2017-02-22 [PMID: 28223698] (Mouse) Mouse
Intravenous hMSCs Ameliorate Acute Pancreatitis in Mice via Secretion of Tumor Necrosis Factor-? Stimulated Gene/Protein 6 Sci Rep, 2016-12-05;6(0):38438. 2016-12-05 [PMID: 27917949] (Mouse) Mouse
Reed , Johanna, Stone , Matthew, Beadnell , Thomas C, Ryu , Yungil, Griffin , Timothy, Schwertfeger , Kathryn Fibroblast growth factor receptor 1 activation in mammary tumor cells promotes macrophage recruitment in a CX3CL1-dependent manner. PLoS ONE, 2012-09-24;7(9):e45877. 2012-09-24 [PMID: 23029290] (Mouse) Mouse
Tighe RM, Li Z, Potts EN, Frush S, Liu N, Gunn MD, Foster WM, Noble PW, Hollingsworth JW Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. J. Immunol., 2011-09-19;187(9):4800-8. 2011-09-19 [PMID: 21930959] (Mouse) Mouse
Ishida Y, Hayashi T, Goto T, Kimura A, Akimoto S, Mukaida N, Kondo T Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis. J. Immunol., 2008-09-15;181(6):4208-18. 2008-09-15 [PMID: 18768878] (Mouse) Mouse
Trujillo G, O'Connor EC, Kunkel SL, Hogaboam CM A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis. Am. J. Pathol., 2008-04-10;172(5):1209-21. 2008-04-10 [PMID: 18403600] (Mouse) Mouse
Ren T, Chen Q, Tian Z, Wei H Down-regulation of surface fractalkine by RNA interference in B16 melanoma reduced tumor growth in mice. Biochem. Biophys. Res. Commun., 2007-10-29;364(4):978-84. 2007-10-29 [PMID: 17971299] (Mouse) Mouse
Show All 11 Publications.

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Bioinformatics

Gene Symbol Cx3cl1