Recombinant Human GDNF Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Glial Cell Line-derived Neurotrophic Factor (GDNF) is a neurotrophic factor that has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Neuronal subpopulations that have been shown to be affected by GDNF include motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons.

Native GDNF, a disulfide-linked homodimeric glycoprotein, is a novel member of the TGF-beta  superfamily. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. NS0 expressed mature human GDNF lacks 31 residues from the amino-terminus of the predicted sequence. This glycosylated recombinant mature human GDNF still contains the seven conserved Cys residues found in all members of the TGF-beta superfamily and is biologically active. The GDNF sequence contains two potential glycosylation sites and insect cell‑expressed recombinant rat GDNF proteins are glycosylated. Mature rat and human GDNF exhibit approximately 93% amino acid sequence identity and show considerable species cross-reactivity. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells.

We have publications tested in 15 confirmed species: Human, Mouse, Rat, Bacteria, Canine, Chicken, Goat, Guinea Pig, N/A, Porcine, Primate, Primate - Macaca mulatta (Rhesus Macaque), Rabbit, Synthetic, Transgenic Mouse.

We have publications tested in 7 applications: Bioassay, Cell Culture, Differentiation, ELISA (Capture), In Vivo, In vitro, Surface Plasmon Resonance.

Showing Publications 1 - 10 of 216. Show All 216 Publications. Collapse Publications.

Publications using 212-GD	Applications	Species
Fernandez Garcia, M;Retallick-Townsley, K;Pruitt, A;Davidson, E;Dai, Y;Fitzpatrick, SE;Sen, A;Cohen, S;Livoti, O;Khan, S;Dossou, G;Cheung, J;Deans, PJM;Wang, Z;Huckins, L;Hoffman, E;Brennand, K; Dynamic convergence of autism disorder risk genes across neurodevelopment bioRxiv : the preprint server for biology 2024-08-24 [PMID: 39229156] (Bioassay, Human)	Bioassay	Human
Costa, MFD;Rösler, TW;Höglinger, GU; Exploring the neuroprotective potential of Nrf2-pathway activators against annonacin toxicity Scientific reports 2024-08-29 [PMID: 39209951] (Bioassay, Human)	Bioassay	Human
Khampang, S;Lorthongpanich, C;Laowtammathron, C;Klaihmon, P;Meesa, S;Suksomboon, W;Jiamvoraphong, N;Kheolamai, P;Luanpitpong, S;Easley, CA;Mahyari, E;Issaragrisil, S; The dynamic expression of YAP is essential for the development of male germ cells derived from human embryonic stem cells Scientific reports 2024-07-08 [PMID: 38977826] (Bioassay, Human)	Bioassay	Human
Werren, EA;Peirent, ER;Jantti, H;Guxholli, A;Srivastava, KR;Orenstein, N;Narayanan, V;Wiszniewski, W;Dawidziuk, M;Gawlinski, P;Umair, M;Khan, A;Khan, SN;Geneviève, D;Lehalle, D;van Gassen, KLI;Giltay, JC;Oegema, R;van Jaarsveld, RH;Rafiullah, R;Rappold, GA;Rabin, R;Pappas, JG;Wheeler, MM;Bamshad, MJ;Tsan, YC;Johnson, MB;Keegan, CE;Srivastava, A;Bielas, SL; Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations Cell death & disease 2024-05-30 [PMID: 38816421] (Bioassay, Human)	Bioassay	Human
Renner, N;Schöb, F;Pape, R;Suciu, I;Spreng, AS;Ückert, AK;Cöllen, E;Bovio, F;Chilian, B;Bauer, J;Röpcke, S;Bergemann, J;Leist, M;Schildknecht, S; Modeling ferroptosis in human dopaminergic neurons: Pitfalls and opportunities for neurodegeneration research Redox biology 2024-04-24 [PMID: 38688061] (Bioassay, Human)	Bioassay	Human
Martin, EJ;Santacruz, C;Mitevska, A;Jones, IE;Krishnan, G;Gao, FB;Finan, JD;Kiskinis, E; Traumatic injury causes selective degeneration and TDP-43 mislocalization in human iPSC-derived C9orf72 -associated ALS/FTD motor neurons bioRxiv : the preprint server for biology 2024-03-26 [PMID: 38585915] (Bioassay, Human)	Bioassay	Human
Wang, M;Zhang, L;Novak, SW;Yu, J;Gallina, IS;Xu, LL;Lim, CK;Fernandes, S;Shokhirev, MN;Williams, AE;Saxena, MD;Coorapati, S;Parylak, SL;Quintero, C;Molina, E;Andrade, LR;Manor, U;Gage, FH; Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain Nature biotechnology 2024-02-28 [PMID: 38418648] (Bioassay, Human)	Bioassay	Human
Liu, J;Prahl, LS;Huang, A;Hughes, AJ; Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation bioRxiv : the preprint server for biology 2024-02-08 [PMID: 38370771] (Bioassay, Canine)	Bioassay	Canine
Zeng, Y;Lovchykova, A;Akiyama, T;Liu, C;Guo, C;Jawahar, VM;Sianto, O;Calliari, A;Prudencio, M;Dickson, DW;Petrucelli, L;Gitler, AD; TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes bioRxiv : the preprint server for biology 2024-01-22 [PMID: 38328059] (Bioassay, Human)	Bioassay	Human
Song, Y;Zhang, X;Desmarais, JA;Nagano, M; Postnatal development of mouse spermatogonial stem cells as determined by immunophenotype, regenerative capacity, and long-term culture-initiating ability: a model for practical applications Scientific reports 2024-01-27 [PMID: 38280889] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Zholudeva, LV;Fortino, T;Agrawal, A;Vila, OF;Williams, M;McDevitt, T;Lane, MA;Srivastava, D; Human spinal interneurons repair the injured spinal cord through synaptic integration bioRxiv : the preprint server for biology 2024-01-12 [PMID: 38260390] (Bioassay, Human)	Bioassay	Human
Kojima, R;Paslawski, W;Lyu, G;Arenas, E;Zhang, X;Svenningsson, P; Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations International journal of molecular sciences 2024-01-04 [PMID: 38203854] (Bioassay, Human)	Bioassay	Human
Maimaitili, M;Chen, M;Febbraro, F;Ucuncu, E;Kelly, R;Niclis, JC;Christiansen, JR;Mermet-Joret, N;Niculescu, D;Lauritsen, J;Iannielli, A;Klæstrup, IH;Jensen, UB;Qvist, P;Nabavi, S;Broccoli, V;Nykjær, A;Romero-Ramos, M;Denham, M; Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells Nature communications 2023-12-05 [PMID: 38052784] (Bioassay, Human)	Bioassay	Human
Marmolejo-Garza, A;Krabbendam, IE;Luu, MDA;Brouwer, F;Trombetta-Lima, M;Unal, O;O'Connor, SJ;Majerníková, N;Elzinga, CRS;Mammucari, C;Schmidt, M;Madesh, M;Boddeke, E;Dolga, AM; Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis Cell death & disease 2023-11-25 [PMID: 38007529] (Bioassay, Human)	Bioassay	Human
Kovács, T;Halasy, V;Peth?, C;Sz?cs, E;Soós, Á;Dóra, D;de Santa Barbara, P;Faure, S;Stavely, R;Goldstein, AM;Nagy, N; Essential Role of BMP4 Signaling in the Avian Ceca in Colorectal Enteric Nervous System Development International journal of molecular sciences 2023-10-27 [PMID: 37958648] (Bioassay, Chicken)	Bioassay	Chicken
Ortega, JA;Sasselli, IR;Boccitto, M;Fleming, AC;Fortuna, TR;Li, Y;Sato, K;Clemons, TD;Mckenna, ED;Nguyen, TP;Anderson, EN;Asin, J;Ichida, JK;Pandey, UB;Wolin, SL;Stupp, SI;Kiskinis, E; CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology Science advances 2023-11-10 [PMID: 37948524] (Bioassay, Human)	Bioassay	Human
Ückert, AK;Rütschlin, S;Gutbier, S;Wörz, NC;Miah, MR;Martins, AC;Hauer, I;Holzer, AK;Meyburg, B;Mix, AK;Hauck, C;Aschner, M;Böttcher, T;Leist, M; Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration Environment international 2023-10-01 [PMID: 37797477] (Bioassay, Human)	Bioassay	Human
Tsioras, K;Smith, KC;Edassery, SL;Garjani, M;Li, Y;Williams, C;McKenna, ED;Guo, W;Wilen, AP;Hark, TJ;Marklund, SL;Ostrow, LW;Gilthorpe, JD;Ichida, JK;Kalb, RG;Savas, JN;Kiskinis, E; Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis Cell reports 2023-09-25 [PMID: 37776851] (Cell Culture, Human)	Cell Culture	Human
Lim, CM;González Díaz, A;Fuxreiter, M;Pun, FW;Zhavoronkov, A;Vendruscolo, M; Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation Proceedings of the National Academy of Sciences of the United States of America 2023-10-03 [PMID: 37774095] (Bioassay, Human)	Bioassay	Human
Pan, AL;Audrain, M;Sakakibara, E;Joshi, R;Zhu, X;Wang, Q;Wang, M;Beckmann, ND;Schadt, EE;Gandy, S;Zhang, B;Ehrlich, ME;Salton, SR; Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice bioRxiv : the preprint server for biology 2023-08-25 [PMID: 37662269] (Bioassay, Human)	Bioassay	Human
Mann, JR;McKenna, ED;Mawrie, D;Papakis, V;Alessandrini, F;Anderson, EN;Mayers, R;Ball, HE;Kaspi, E;Lubinski, K;Baron, DM;Tellez, L;Landers, JE;Pandey, UB;Kiskinis, E; Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import Science advances 2023-08-18 [PMID: 37585529] (Bioassay, Human)	Bioassay	Human
Clayton, BLL;Barbar, L;Sapar, M;Rusielewicz, T;Kalpana, K;Migliori, B;NYSCF Global Stem Cell Array® Team, ;Paull, D;Brenner, K;Moroziewicz, D;Sand, IK;Casaccia, P;Tesar, PJ;Fossati, V; Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis bioRxiv : the preprint server for biology 2023-08-02 [PMID: 37577713] (Bioassay, Human)	Bioassay	Human
Jourdon, A;Wu, F;Mariani, J;Capauto, D;Norton, S;Tomasini, L;Amiri, A;Suvakov, M;Schreiner, JD;Jang, Y;Panda, A;Nguyen, CK;Cummings, EM;Han, G;Powell, K;Szekely, A;McPartland, JC;Pelphrey, K;Chawarska, K;Ventola, P;Abyzov, A;Vaccarino, FM; Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis Nature neuroscience 2023-08-10 [PMID: 37563294] (Bioassay, Human)	Bioassay	Human
Glass, MR;Waxman, EA;Yamashita, S;Lafferty, M;Beltran, A;Farah, T;Patel, NK;Matoba, N;Ahmed, S;Srivastava, M;Drake, E;Davis, LT;Yeturi, M;Sun, K;Love, MI;Hashimoto-Torii, K;French, DL;Stein, JL; Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture bioRxiv : the preprint server for biology 2023-07-29 [PMID: 37546772] (Bioassay, Human)	Bioassay	Human
Jin, C;Wang, Z;Li, P;Tang, J;Jiao, T;Li, Y;Ou, J;Zou, D;Li, M;Mang, X;Liu, J;Ma, Y;Wu, X;Shi, J;Chen, S;He, M;Lu, Y;Zhang, N;Miao, S;Sun, F;Wang, L;Li, K;Yu, J;Song, W; Decoding the spermatogonial stem cell niche under physiological and recovery conditions in adult mice and humans Science advances 2023-08-04 [PMID: 37540753] (Bioassay, Human)	Bioassay	Human
Oiwa, K;Watanabe, S;Onodera, K;Iguchi, Y;Kinoshita, Y;Komine, O;Sobue, A;Okada, Y;Katsuno, M;Yamanaka, K; Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis Science advances 2023-08-04 [PMID: 37540751] (Bioassay, Human)	Bioassay	Human
Sinclair, P;Hakeem, J;Kumar, SG;Loser, D;Dixit, K;Leist, M;Kraushaar, U;Kabbani, N; Proteomic responses in the human dopaminergic LUHMES cell line to imidacloprid and its metabolites imidacloprid-olefin and desnitro-imidacloprid Pesticide biochemistry and physiology 2023-08-01 [PMID: 37532312] (Bioassay, Human)	Bioassay	Human
Onda-Ohto, A;Hasegawa-Ogawa, M;Matsuno, H;Shiraishi, T;Bono, K;Hiraki, H;Kanegae, Y;Iguchi, Y;Okano, HJ; Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress Molecular brain 2023-07-26 [PMID: 37496071] (Bioassay, Human)	Bioassay	Human
Rajachandran, S;Zhang, X;Cao, Q;Caldeira-Brant, AL;Zhang, X;Song, Y;Evans, M;Bukulmez, O;Grow, EJ;Nagano, M;Orwig, KE;Chen, H; Dissecting the spermatogonial stem cell niche using spatial transcriptomics Cell reports 2023-07-01 [PMID: 37393620] (Cell Culture, Mouse)	Cell Culture	Mouse
Mubariz, F;Saadin, A;Lingenfelter, N;Sarkar, C;Banerjee, A;Lipinski, MM;Awad, O; Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson's disease Frontiers in neuroscience 2023-06-02 [PMID: 37332877] (Bioassay, Human)	Bioassay	Human
Tam, KW;Wong, CY;Wu, KL;Lam, G;Liang, X;Wong, WT;Li, MT;Liu, WY;Cai, S;Shea, GK;Shum, DK;Chan, YS; IPSC-Derived Sensory Neurons Directing Fate Commitment of Human BMSC-Derived Schwann Cells: Applications in Traumatic Neural Injuries Cells 2023-05-25 [PMID: 37296600] (Bioassay, Human)	Bioassay	Human
Hartmann, J;Henschel, N;Bartmann, K;D�nmez, A;Brockerhoff, G;Koch, K;Fritsche, E; Molecular and Functional Characterization of Different BrainSphere Models for Use in Neurotoxicity Testing on Microelectrode Arrays Cells 2023-04-27 [PMID: 37174670] (Bioassay, Human)	Bioassay	Human
MH Berryer, G Rizki, A Nathanson, JA Klein, D Trendafilo, SG Susco, D Lam, A Messana, KM Holton, KW Karhohs, BA Cimini, K Pfaff, AE Carpenter, LL Rubin, LE Barrett High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly Elife, 2023-04-21;12(0):. 2023-04-21 [PMID: 37083703] (Bioassay, Human)	Bioassay	Human
C Li, Z Yao, L Ma, X Song, W Wang, C Wan, S Ren, D Chen, Y Zheng, YT Zhu, G Chang, S Wu, K Miao, F Luo, XY Zhao Lovastatin promotes the self-renewal of murine and primate spermatogonial stem cells Stem Cell Reports, 2023-04-11;18(4):969-984. 2023-04-11 [PMID: 37044069] (Bioassay, Human)	Bioassay	Human
SD Sharma, BK Reddy, R Pal, TE Ritakari, JD Cooper, BT Selvaraj, PC Kind, S Chandran, DJA Wyllie, S Chattarji Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons Cell Reports, 2023-04-04;42(4):112344. 2023-04-04 [PMID: 37018073] (Bioassay, Human)	Bioassay	Human
YW Jun, S Lee, BK Ban, JA Lee, FB Gao Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis Autophagy, 2023-02-27;0(0):1-17. 2023-02-27 [PMID: 36849436] (Bioassay, Human)	Bioassay	Human
HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, K Dempster, JA Silvaroli, JL Smith, H Wichterle, NS Pabla, SK Ultanir, AN Bullock, DH Drewry, AD Axtman A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective bioRxiv : the preprint server for biology, 2023-02-10;0(0):. 2023-02-10 [PMID: 36798313] (Bioassay, Human)	Bioassay	Human
GR Linares, Y Li, WH Chang, J Rubin-Sigl, S Mendonca, S Hong, Y Eoh, W Guo, YH Huang, J Chang, S Tu, N Dorjsuren, M Santana, ST Hung, J Yu, J Perez, M Chickering, TY Cheng, CC Huang, SJ Lee, HJ Deng, KT Bach, K Gray, V Subramanya, J Rosenfeld, SV Alworth, H Goodarzi, JK Ichida SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS Cell Stem Cell, 2023-02-02;30(2):171-187.e14. 2023-02-02 [PMID: 36736291] (Bioassay, Human)	Bioassay	Human
O Pietiläine, A Trehan, D Meyer, J Mitchell, M Tegtmeyer, V Valakh, H Gebre, T Chen, E Vartiainen, SL Farhi, K Eggan, SA McCarroll, R Nehme Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons Cell Reports, 2023-01-12;42(1):111988. 2023-01-12 [PMID: 36640364] (Bioassay, Human)	Bioassay	Human
Z Álvarez, JA Ortega, K Sato, IR Sasselli, AN Kolberg-Ed, R Qiu, KA Marshall, TP Nguyen, CS Smith, KA Quinlan, V Papakis, Z Syrgiannis, NA Sather, C Musumeci, E Engel, SI Stupp, E Kiskinis Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons Cell Stem Cell, 2023-01-12;0(0):. 2023-01-12 [PMID: 36638801] (Bioassay, Human)	Bioassay	Human
CB Pantazis, A Yang, E Lara, JA McDonough, C Blauwendra, L Peng, H Oguro, J Kanaujiya, J Zou, D Sebesta, G Pratt, E Cross, J Blockwick, P Buxton, L Kinner-Bib, C Medura, C Tompkins, S Hughes, M Santiana, F Faghri, MA Nalls, D Vitale, S Ballard, YA Qi, DM Ramos, KM Anderson, J Stadler, P Narayan, J Papademetr, L Reilly, MP Nelson, S Aggarwal, LU Rosen, P Kirwan, V Pisupati, SL Coon, SW Scholz, T Priebe, M Öttl, J Dong, M Meijer, LJM Janssen, VS Lourenco, R van der Ka, D Crusius, D Paquet, AC Raulin, G Bu, A Held, BJ Wainger, RMC Gabriele, JM Casey, S Wray, D Abu-Bonsra, CL Parish, MS Beccari, DW Cleveland, E Li, IVL Rose, M Kampmann, C Calatayud, P Verstreken, L Heinrich, MY Chen, B Schüle, D Dou, ELF Holzbaur, MC Zanellati, R Basundra, M Deshmukh, S Cohen, R Khanna, M Raman, ZS Nevin, M Matia, J Van Lent, V Timmerman, BR Conklin, K Johnson Ch, K Zhang, S Funes, DA Bosco, L Erlebach, M Welzer, D Kronenberg, G Lyu, E Arenas, E Coccia, L Sarrafha, T Ahfeldt, JC Marioni, WC Skarnes, MR Cookson, ME Ward, FT Merkle A reference human induced pluripotent stem cell line for large-scale collaborative studies Cell Stem Cell, 2022-12-01;29(12):1685-1702.e22. 2022-12-01 [PMID: 36459969] (Bioassay, Human)	Bioassay	Human
JR Herdy, L Traxler, RK Agarwal, L Karbacher, JCM Schlachetz, L Boehnke, D Zangwill, D Galasko, CK Glass, J Mertens, FH Gage Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease Cell Stem Cell, 2022-12-01;29(12):1637-1652.e6. 2022-12-01 [PMID: 36459967] (Bioassay, Human)	Bioassay	Human
M Jones, A Cunningham, N Frank, D Sethi The monoculture of cord-blood-derived CD34+ cells by an automated, membrane-based dynamic perfusion system with a novel cytokine cocktail Stem Cell Reports, 2022-11-03;0(0):. 2022-11-03 [PMID: 36332632] (Bioassay, Human)	Bioassay	Human
G Kim, L Nakayama, JA Blum, T Akiyama, S Boeynaems, M Chakrabort, J Couthouis, E Tassoni-Ts, CM Rodriguez, MC Bassik, AD Gitler Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2 Cell Reports, 2022-10-25;41(4):111508. 2022-10-25 [PMID: 36288714] (Bioassay, Human)	Bioassay	Human
C Seah, MS Breen, T Rusielewic, HN Bader, C Xu, CJ Hunter, B McCarthy, PJM Deans, M Chattopadh, J Goldberg, F Desarnaud, I Makotkine, JD Flory, LM Bierer, M Staniskyte, NYSCF Glob, SA Noggle, LM Huckins, D Paull, KJ Brennand, R Yehuda Modeling gene � environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression Nature Neuroscience, 2022-10-20;25(11):1434-1445. 2022-10-20 [PMID: 36266471] (Bioassay, Human)	Bioassay	Human
T Patel, J Hammelman, S Aziz, S Jang, M Closser, TL Michaels, JA Blum, DK Gifford, H Wichterle Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro Nature Communications, 2022-09-15;13(1):5427. 2022-09-15 [PMID: 36109497] (Cell Culture, Mouse)	Cell Culture	Mouse
L Mahoney-Sa, H Bouchaoui, I Boussaad, A Jonneaux, K Timmerman, O Berdeaux, S Ayton, R Krüger, JA Duce, D Devos, JC Devedjian Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition Cell Reports, 2022-08-23;40(8):111231. 2022-08-23 [PMID: 36001957] (Bioassay, Human)	Bioassay	Human
R Lieberman, LK Cortes, G Gao, H Park, B Wang, PL Jones, RB Hunter, JP Leonard, RH Barker Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease PLoS ONE, 2022-08-03;17(8):e0271360. 2022-08-03 [PMID: 35921286] (Bioassay, Human)	Bioassay	Human
K ?uczkowska, O Taryma-Le?, J Bi?kowski, KE Soko?owska, D Strapagiel, J Jarczak, E Paczkowska, B Machali?sk, TK Wojdacz Long-Term Treatment with Bortezomib Induces Specific Methylation Changes in Differentiated Neuronal Cells Cancers, 2022-07-13;14(14):. 2022-07-13 [PMID: 35884461] (Bioassay, Human)	Bioassay	Human
M Sawamura, K Imamura, R Hikawa, T Enami, A Nagahashi, H Yamakado, H Ichijo, T Fujisawa, H Yamashita, S Minamiyama, M Kaido, H Wada, M Urushitani, H Inoue, N Egawa, R Takahashi Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation Scientific Reports, 2022-07-25;12(1):12636. 2022-07-25 [PMID: 35879519] (Bioassay, Human)	Bioassay	Human
Y Chen, Q Yin, XY Cheng, JR Zhang, H Jin, K Li, CJ Mao, F Wang, HZ Bei, CF Liu G2019S LRRK2 Mutation Enhances MPP+-Induced Inflammation of Human Induced Pluripotent Stem Cells-Differentiated Dopaminergic Neurons Frontiers in Neuroscience, 2022-07-06;16(0):947927. 2022-07-06 [PMID: 35873822] (Bioassay, Human)	Bioassay	Human
MA Hossain, M Hasegawa-O, Y Manome, M Igarashi, C Wu, K Suzuki, J Igarashi, T Iwamoto, HJ Okano, Y Eto Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells Oncogene, 2022-02-21;31(0):100852. 2022-02-21 [PMID: 35782608] (Bioassay, Human)	Bioassay	Human
MK Eltahir, M Nakamori, S Hattori, T Kimura, H Mochizuki, S Nagano Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1 PLoS ONE, 2022-07-01;17(7):e0269683. 2022-07-01 [PMID: 35776705] (Bioassay, Human)	Bioassay	Human
FC Yang, JL Vivian, C Traxler, SM Shapiro, JA Stanford MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus Cell Transplantation, 2022-01-01;31(0):9636897221101. 2022-01-01 [PMID: 35596532] (Bioassay, Human)	Bioassay	Human
AK Holzer, I Suciu, C Karreman, T Goj, M Leist Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro International Journal of Molecular Sciences, 2022-03-29;23(7):. 2022-03-29 [PMID: 35409095] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-04-05;23(6):e54041. 2022-04-05 [PMID: 35384245] (Bioassay, Human)	Bioassay	Human
JM Suárez-Riv, CJ Pastor-Mal, A Romero-Gon, D Gómez-Fern, S Povea-Cabe, M Álvarez-Có, I Villalón-G, M Talaverón-, A Suárez-Car, M Munuera-Ca, JA Sánchez-Al Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases Frontiers in Pharmacology, 2022-03-18;13(0):862085. 2022-03-18 [PMID: 35370630] (Bioassay, Human)	Bioassay	Human
M Häkli, S Jäntti, T Joki, L Sukki, K Tornberg, K Aalto-Setä, P Kallio, M Pekkanen-M, S Narkilahti Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip International Journal of Molecular Sciences, 2022-03-15;23(6):. 2022-03-15 [PMID: 35328569] (Bioassay, Human)	Bioassay	Human
L Torres-Gar, JM P Domingue, E Brandi, C Haikal, JM Mudannayak, IC Brás, E Gerhardt, W Li, A Svanbergss, TF Outeiro, GK Gouras, JY Li Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation Scientific Reports, 2022-02-22;12(1):2987. 2022-02-22 [PMID: 35194057] (Bioassay, Human)	Bioassay	Human
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Lundgren TK, Nakahata K, Fritz N, Rebellato P, Zhang S, Uhlen P RET PLC-gamma phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration. PLoS ONE, 2012-02-15;7(2):e31258. 2012-02-15 [PMID: 22355350] (Bioassay, Human)	Bioassay	Human
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-07-07;286(34):30034-46. 2011-07-07 [PMID: 21737454] (Surface Plasmon Resonance, Human, Mouse)	Surface Plasmon Resonance	Human, Mouse
Kubota H, Wu X, Goodyear SM, Avarbock MR, Brinster RL Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties. FASEB J., 2011-04-27;25(0):2604-14. 2011-04-27 [PMID: 21525489] (Bioassay, Rabbit)	Bioassay	Rabbit
Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology, 2010-02-11;58(7):1114-21. 2010-02-11 [PMID: 20153340] (In Vivo, Rat)	In Vivo	Rat
Wang YC, Wu YT, Huang HY, Lin HI, Lo LW, Tzeng SF, Yang CS Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury. Biomaterials, 2008-09-06;29(34):4546-53. 2008-09-06 [PMID: 18774604] (In Vivo, Rat)	In Vivo	Rat
Lu B, PereiraPerrin M A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect. Immun., 2008-06-09;76(8):3530-8. 2008-06-09 [PMID: 18541656] (ELISA (Capture), Bacteria)	ELISA (Capture)	Bacteria
Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons. Stem Cells, 2008-04-17;26(7):1705-12. 2008-04-17 [PMID: 18420830] (Bioassay, Human)	Bioassay	Human
Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development, 2007-09-01;134(18):3327-38. 2007-09-01 [PMID: 17720696] (Bioassay, Mouse)	Bioassay	Mouse
Pankratz MT, Li XJ, Lavaute TM, Lyons EA, Chen X, Zhang SC Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells, 2007-03-01;25(6):1511-20. 2007-03-01 [PMID: 17332508] (Bioassay, Human, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Human, Primate - Macaca mulatta (Rhesus Macaque)
Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine)	Bioassay	Porcine
Nagy N, Goldstein AM Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system. Dev. Biol., 2006-03-06;293(1):203-17. 2006-03-06 [PMID: 16519884] (Bioassay, Chicken)	Bioassay	Chicken
Girard BM, Young BA, Buttolph TR, Locknar SA, White SL, Parsons RL Trophic factor modulation of cocaine- and amphetamine-regulated transcript peptide expression in explant cultured guinea-pig cardiac neurons. Neuroscience, 2006-03-03;139(4):1329-41. 2006-03-03 [PMID: 16516394] (Bioassay, Guinea Pig)	Bioassay	Guinea Pig
Castelo-Branco G, Sousa KM, Bryja V, Pinto L, Wagner J, Arenas E Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Mol. Cell. Neurosci., 2005-10-21;31(2):251-62. 2005-10-21 [PMID: 16243537] (Bioassay, Rat)	Bioassay	Rat
Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A., 2004-08-13;101(34):12543-8. 2004-08-13 [PMID: 15310843] (Bioassay, Human, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Human, Primate - Macaca mulatta (Rhesus Macaque)
Esper RM, Loeb JA Rapid axoglial signaling mediated by neuregulin and neurotrophic factors. J. Neurosci., 2004-07-07;24(27):6218-27. 2004-07-07 [PMID: 15240814] (Bioassay, Chicken)	Bioassay	Chicken
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Array 212-GD

• GDNF Antibodies
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