Mouse CCL4/MIP-1 beta Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL4/MIP-1 beta is a beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. It attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP-1 alpha. It signals through CCR5, and an N-terminally trimmed form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV-1 which utilizes CCR5 as a coreceptor.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ELISA Capture.

Showing Publications 1 - 10 of 33. Show All 33 Publications. Collapse Publications.

Publications using MMB00	Applications	Species
Barakat, R;Chatterjee, J;Mu, R;Qi, X;Gu, X;Smirnov, I;Cobb, O;Gao, K;Barnes, A;Kipnis, J;Gutmann, DH; Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains mouse low-grade glioma growth Nature communications 2024-11-28 [PMID: 39609412] (Mouse)		Mouse
Sha, L;Li, J;Shen, H;Wang, Q;Meng, P;Zhang, X;Deng, Y;Zhu, W;Xu, Q; LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis Cell reports 2023-08-11 [PMID: 37573508] (Mouse)		Mouse
J Chatterjee, S Sanapala, O Cobb, A Bewley, AK Goldstein, E Cordell, X Ge, JR Garbow, MJ Holtzman, DH Gutmann Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia Nature Communications, 2021-12-08;12(1):7122. 2021-12-08 [PMID: 34880260] (Mouse)		Mouse
NJ Parekh, TE Krouse, IE Reider, RP Hobbs, BM Ward, CC Norbury Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden PLoS Pathog., 2019-10-11;15(10):e1007778. 2019-10-11 [PMID: 31603920] (Mouse)		Mouse
K Nakajima, M Ono, U Radovi?, S Dizdarevi?, SI Tomizawa, K Kuroha, G Naganatsu, I Hoshi, R Matsunaga, T Shirakawa, T Kurosawa, Y Miyazaki, M Seki, Y Suzuki, H Koseki, M Nakamura, T Suda, K Ohbo Lack of whey acidic protein four disulphide core (WFDC) 2 protease inhibitor causes neonatal death from respiratory failure in mice Dis Model Mech, 2019-11-12;0(0):. 2019-11-12 [PMID: 31562139] (Mouse)		Mouse
N Simon, A Antignani, SM Hewitt, M Gadina, C Alewine, D FitzGerald Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells JCI Insight, 2019-03-07;0(0):. 2019-03-07 [PMID: 30720466] (Mouse)		Mouse
F Allen, ID Bobanga, P Rauhe, D Barkauskas, N Teich, C Tong, J Myers, AY Huang CCL3 augments tumor rejection and enhances CD8+T cell infiltration through NK and CD103+dendritic cell recruitment via IFN? Oncoimmunology, 2017-11-20;7(3):e1393598. 2017-11-20 [PMID: 29399390] (ELISA Capture, Mouse)	ELISA Capture	Mouse
NA Bezman, A Jhatakia, AY Kearney, T Brender, M Maurer, K Henning, MR Jenkins, AJ Rogers, PJ Neeson, AJ Korman, MD Robbins, RF Graziano PD-1 blockade enhances elotuzumab efficacy in mouse tumor models Blood Adv, 2017-05-08;1(12):753-765. 2017-05-08 [PMID: 29296719] (Mouse)		Mouse
Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms Nat Commun, 2016-05-13;7(0):11492. 2016-05-13 [PMID: 27173585] (Mouse)		Mouse
Kohno H, Maeda T, Perusek L, Pearlman E, Maeda A CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J Immunol, 2014-03-17;192(8):3816-27. 2014-03-17 [PMID: 24639355] (Mouse)		Mouse
Brenndorfer E, Brass A, Karthe J, Ahlen G, Bode J, Sallberg M Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy. J Immunol, 2014-01-17;192(4):1671-80. 2014-01-17 [PMID: 24442435] (Mouse)		Mouse
Guirnalda P, Wood L, Goenka R, Crespo J, Paterson Y Interferon gamma-induced intratumoral expression of CXCL9 alters the local distribution of T cells following immunotherapy with Oncoimmunology, 2013-07-23;2(8):e25752. 2013-07-23 [PMID: 24083082] (Mouse)		Mouse
Fukuyama Y, Tokuhara D, Sekine S, Aso K, Kataoka K, Davydova J, Yamamoto M, Gilbert R, Tokuhara Y, Fujihashi K, Kunisawa J, Yuki Y, Kiyono H, McGhee J, Fujihashi K Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS ONE, 2013-04-02;8(4):e60453. 2013-04-02 [PMID: 23565250] (Mouse)		Mouse
Gottfries J, Melgar S, Michaelsson E Modelling of mouse experimental colitis by global property screens: a holistic approach to assess drug effects in inflammatory bowel disease. PLoS ONE, 2012-01-18;7(1):e30005. 2012-01-18 [PMID: 22279558] (Mouse)		Mouse
Doodes PD, Cao Y, Hamel KM, Wang Y, Rodeghero RL, Kobezda T, Finnegan A CCR5 is involved in resolution of inflammation in proteoglycan-induced arthritis. Arthritis Rheum., 2009-10-01;60(10):2945-53. 2009-10-01 [PMID: 19790057] (Mouse)		Mouse
Mikhak Z, Farsidjani A, Luster AD Endotoxin augmented antigen-induced Th1 cell trafficking amplifies airway neutrophilic inflammation. J. Immunol., 2009-06-15;182(12):7946-56. 2009-06-15 [PMID: 19494319] (Mouse)		Mouse
Johnson TR, Rao S, Seder RA, Chen M, Graham BS TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity. Vaccine, 2009-04-03;27(23):3045-52. 2009-04-03 [PMID: 19428918] (Mouse)		Mouse
Di Liberto D, Locati M, Caccamo N, Vecchi A, Meraviglia S, Salerno A, Sireci G, Nebuloni M, Caceres N, Cardona PJ, Dieli F, Mantovani A Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection. J. Exp. Med., 2008-08-11;205(9):2075-84. 2008-08-11 [PMID: 18695004] (Mouse)		Mouse
Johnson TR, Rothenberg ME, Graham BS Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein. J. Leukoc. Biol., 2008-06-02;84(3):748-59. 2008-06-02 [PMID: 18519743] (Mouse)		Mouse
Fujita H, Asahina A, Komine M, Tamaki K The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells. Cell. Immunol., 2007-05-15;245(2):70-9. 2007-05-15 [PMID: 17507001] (Mouse)		Mouse
Meagher C, Arreaza G, Peters A, Strathdee CA, Gilbert PA, Mi QS, Santamaria P, Dekaban GA, Delovitch TL CCL4 protects from type 1 diabetes by altering islet beta-cell-targeted inflammatory responses. Diabetes, 2007-03-01;56(3):809-17. 2007-03-01 [PMID: 17327452] (Mouse)		Mouse
Batkai S, Osei-Hyiaman D, Pan H, El-Assal O, Rajesh M, Mukhopadhyay P, Hong F, Harvey-White J, Jafri A, Hasko G, Huffman JW, Gao B, Kunos G, Pacher P Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB J., 2007-02-27;21(8):1788-800. 2007-02-27 [PMID: 17327359] (Mouse)		Mouse
He X, Schoeb TR, Panoskaltsis-Mortari A, Zinn KR, Kesterson RA, Zhang J, Samuel S, Hicks MJ, Hickey MJ, Bullard DC Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice. J. Immunol., 2006-12-15;177(12):8748-56. 2006-12-15 [PMID: 17142777] (Mouse)		Mouse
Drmotova M, Rehnstrom E, Jansson L Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis. Cytokine, 2006-11-07;35(5):275-83. 2006-11-07 [PMID: 17088072] (Mouse)		Mouse
Weighardt H, Mages J, Jusek G, Kaiser-Moore S, Lang R, Holzmann B Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis. Infect. Immun., 2006-06-01;74(6):3618-32. 2006-06-01 [PMID: 16714594] (Mouse)		Mouse
Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem. Biophys. Res. Commun., 2006-05-12;345(3):1122-30. 2006-05-12 [PMID: 16713992] (Mouse)		Mouse
Trabattoni D, Clivio A, Bray DH, Bhagat L, Beltrami S, Maffeis G, Cesana E, Lowry P, Lissoni F, Kandimalla ER, Sullivan T, Agrawal S, Bartholomew R, Clerici M Immunization with gp120-depleted whole killed HIV immunogen and a second-generation CpG DNA elicits strong HIV-specific responses in mice. Vaccine, 2005-09-22;24(9):1470-7. 2005-09-22 [PMID: 16221513] (Mouse)		Mouse
Johnson TR, Varga SM, Braciale TJ, Graham BS Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV. J. Virol., 2004-08-01;78(16):8753-60. 2004-08-01 [PMID: 15280483] (Mouse)		Mouse
Toth B, Alexander M, Daniel T, Hubbard WJ, Schwacha MG The role of gammadelta T cells in the regulation of neutrophil-mediated tissue damage after thermal injury. J. Leukoc. Biol., 2004-06-14;76(3):545-52. 2004-06-14 [PMID: 15197233] (Mouse)		Mouse
Virag L, Bai P, Bak I, Pacher P, Mabley JG, Liaudet L, Bakondi E, Gergely P, Kollai M, Szabo C Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma. Med. Sci. Monit., 2004-03-01;10(3):BR77-83. 2004-03-01 [PMID: 14976461] (Mouse)		Mouse
Menten P, Saccani A, Dillen C, Wuyts A, Struyf S, Proost P, Mantovani A, Wang JM, Van Damme J Role of the autocrine chemokines MIP-1alpha and MIP-1beta in the metastatic behavior of murine T cell lymphoma. J. Leukoc. Biol., 2002-10-01;72(4):780-9. 2002-10-01 [PMID: 12377948] (Mouse)		Mouse
Horner AA, Datta SK, Takabayashi K, Belyakov IM, Cinman N, Nguyen MD, Van Uden JH, Berzofsky JA Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites. J. Immunol., 2001-08-01;167(3):1584-91. 2001-08-01 [PMID: 11466380] (Mouse)		Mouse
Medvedev AE, Kopydlowski KM, Vogel SN Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression. J. Immunol., 2000-06-01;164(11):5564-74. 2000-06-01 [PMID: 10820230] (Mouse)		Mouse
Show All 33 Publications. Collapse Publications.

Array MMB00

• CCL4/MIP-1 beta Antibodies
• CCL4/MIP-1 beta ELISA Kit
• CCL4/MIP-1 beta Lysate
• CCL4/MIP-1 beta Proteins
• CCL4/MIP-1 beta ELISAs
• CCL4/MIP-1 beta Proteins and Enzymes