Mouse CCL21/6Ckine DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL21, also known as 6Ckine, TCA-4, SLC, Exodus-2, and A21, is a homeostatic chemokine that signals through CCR7 or CXCR3. CCL21 is constitutively presented on initial lymphatic vessels, high endothelial venules (HEV), and lymph node dendritic cells (DC) where it promotes the docking of DC to lymphatic vessels and the retention of T cells by lymph node DC, resulting in T cell priming for activation. Its upregulation during chronic inflammation or tissue damage promotes fibrosis, inflammatory cytokine production, and neuropathic pain. The soluble chemokine is elevated in rheumatoid arthritis synovial fluid and in the serum of coronary artery disease patients.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 21. Show All 21 Publications. Collapse Publications.

Publications using DY457	Applications	Species
Hopkin, SJ;Pezhman, L;Begum, J;Kavanagh, D;McGettrick, HM;Iqbal, AJ;Chimen, M; Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner Journal of leukocyte biology 2023-06-13 [PMID: 37309034] (Mouse)		Mouse
JD Cherry, ZH Baucom, KG Eppich, D Kirsch, ER Dixon, Y Tripodis, KF Bieniek, K Farrell, K Whitney, M Uretsky, JF Crary, D Dickson, AC McKee Neuroimmune proteins can differentiate between tauopathies Journal of Neuroinflammation, 2022-11-19;19(1):278. 2022-11-19 [PMID: 36403052] (Human)		Human
HP Hsu, YT Chen, YY Chen, CY Lin, PY Chen, SY Liao, CCY Lim, Y Yamaguchi, CL Hsu, IL Dzhagalov Heparan sulfate is essential for thymus growth The Journal of Biological Chemistry, 2021-02-15;0(0):100419. 2021-02-15 [PMID: 33600795] (Mouse)		Mouse
Y Huang, Y Chen, S Zhou, L Chen, J Wang, Y Pei, M Xu, J Feng, T Jiang, K Liang, S Liu, Q Song, G Jiang, X Gu, Q Zhang, X Gao, J Chen Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors Nat Commun, 2020-01-30;11(1):622. 2020-01-30 [PMID: 32001695] (Mouse)		Mouse
L Liu, L Zhao, Y Yang, J Gao, C Hu, B Guo, B Zhu Cytotoxic chemotherapy reduces T cell trafficking to the spleen by downregulating the expression of C-C motif chemokine ligand 21 and C-C motif chemokine ligand 19 Oncol Lett, 2018-08-09;16(4):5013-5019. 2018-08-09 [PMID: 30250567] (Mouse)		Mouse
W Piao, Y Xiong, K Famulski, CC Brinkman, L Li, N Toney, C Wagner, V Saxena, T Simon, JS Bromberg Regulation of T cell afferent lymphatic migration by targeting LT?R-mediated non-classical NF?B signaling Nat Commun, 2018-08-01;9(1):3020. 2018-08-01 [PMID: 30069025] (Mouse)		Mouse
V Besnard, R Dagher, T Madjer, A Joannes, M Jaillet, M Kolb, P Bonniaud, LA Murray, MA Sleeman, B Crestani Identification of periplakin as a major regulator of lung injury and repair in mice JCI Insight, 2018-03-08;3(5):. 2018-03-08 [PMID: 29515024] (Mouse)		Mouse
W Alturaiki, AJ McFarlane, K Rose, R Corkhill, PS McNamara, J Schwarze, BF Flanagan Expression of the B cell differentiation factor BAFF and chemokine CXCL13 in a murine model of Respiratory Syncytial Virus infection Cytokine, 2018-02-01;0(0):. 2018-02-01 [PMID: 29396045] (Mouse)		Mouse
JL Gregory, A Walter, YO Alexandre, JL Hor, R Liu, JZ Ma, S Devi, N Tokuda, Y Owada, LK Mackay, GK Smyth, WR Heath, SN Mueller Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge Cell Rep, 2017-01-10;18(2):406-418. 2017-01-10 [PMID: 28076785] (Mouse)		Mouse
Richner J, Gmyrek G, Govero J, Tu Y, van der Windt G, Metcalf T, Haddad E, Textor J, Miller M, Diamond M Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection. PLoS Pathog, 2015-07-23;11(7):e1005027. 2015-07-23 [PMID: 26204259] (Mouse)		Mouse
Alissafi T, Hatzioannou A, Ioannou M, Sparwasser T, Grun J, Grutzkau A, Verginis P De novo-induced self-antigen-specific Foxp3+ regulatory T cells impair the accumulation of inflammatory dendritic cells in draining lymph nodes. J Immunol, 2015-05-06;194(12):5812-24. 2015-05-06 [PMID: 25948818] (Mouse)		Mouse
Lucas B, White A, Ulvmar M, Nibbs R, Sitnik K, Agace W, Jenkinson W, Anderson G, Rot A CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice. Eur J Immunol, 2015-01-16;45(2):574-83. 2015-01-16 [PMID: 25521433] (Mouse)		Mouse
White C, Villarino N, Sloan S, Ganusov V, Schmidt N Plasmodium suppresses expansion of T cell responses to heterologous infections. J Immunol, 2014-12-10;194(2):697-708. 2014-12-10 [PMID: 25505280] (Mouse)		Mouse
Neill , Daniel R, Saint , Gemma L, Bricio-Moreno , Laura, Fothergill , Joanne L, Southern , Kevin W, Winstanley , Craig, Christmas , Stephen, Slupsky , Joseph R, McNamara , Paul S, Kadioglu , Aras, Flanagan , Brian F The B lymphocyte differentiation factor (BAFF) is expressed in the airways of children with CF and in lungs of mice infected with Pseudomonas aeruginosa. PLoS ONE, 2014-05-21;9(5):e95892. 2014-05-21 [PMID: 24847941] (Mouse)		Mouse
Paradis M, Mindt B, Duerr C, Rojas O, Ng D, Boulianne B, McCarthy D, Yu M, Summers deLuca L, Ward L, Waldron J, Philpott D, Gommerman J, Fritz J A TNF-alpha-CCL20-CCR6 axis regulates Nod1-induced B cell responses. J Immunol, 2014-02-17;192(6):2787-99. 2014-02-17 [PMID: 24534531] (Mouse)		Mouse
Maina , Virginia, Marrella , Veronica, Mantero , Stefano, Cassani , Barbara, Fontana , Elena, Anselmo , Achille, Del Prete , Annalisa, Sozzani , Silvano, Vezzoni , Paolo, Poliani , Pietro L, Villa , Anna Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. J Leukoc Biol, 2013-09-19;94(6):1221-30. 2013-09-19 [PMID: 24052573] (Mouse)		Mouse
Greenlee-Wacker MC, Briseno C, Galvan M, Moriel G, Velazquez P, Bohlson SS Membrane-associated CD93 regulates leukocyte migration and C1q-hemolytic activity during murine peritonitis. J. Immunol., 2011-08-17;187(6):3353-61. 2011-08-17 [PMID: 21849679] (Mouse)		Mouse
Jalili A, Pashenkov M, Kriehuber E, Wagner C, Nakano H, Stingl G, Wagner SN Induction of targeted cell migration by cutaneous administration of a DNA vector encoding a biologically active chemokine CCL21. J. Invest. Dermatol., 2010-02-25;130(6):1611-23. 2010-02-25 [PMID: 20182442] (Mouse)		Mouse
Demoor T, Bracke KR, Maes T, Vandooren B, Elewaut D, Pilette C, Joos GF, Brusselle GG Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis. Eur. Respir. J., 2009-01-22;34(2):405-16. 2009-01-22 [PMID: 19164352] (Mouse)		Mouse
Zhou W, Newcomb DC, Moore ML, Goleniewska K, O'Neal JF, Peebles RS Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses. J. Immunol., 2008-10-15;181(8):5360-7. 2008-10-15 [PMID: 18832692] (Mouse)		Mouse
Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am. J. Pathol., 2007-04-01;170(4):1152-64. 2007-04-01 [PMID: 17392156] (Mouse)		Mouse
Show All 21 Publications. Collapse Publications.

Array DY457

• CCL21/6Ckine Antibodies
• CCL21/6Ckine Lysate
• CCL21/6Ckine Proteins
• CCL21/6Ckine ELISAs
• CCL21/6Ckine Proteins and Enzymes