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MOG Antibody [Unconjugated]

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MOG was detected in perfusion fixed frozen sections of mouse brain (cortex) using 15 µg/mL Goat Anti-Mouse MOG Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2439) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
MOG was detected in perfusion fixed frozen sections of mouse brain (cortex) using 15 µg/mL Goat Anti-Mouse MOG Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2439) overnight at 4 °C. Tissue was ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Biotin
BAF2439
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
AF2439-SP
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MOG Antibody [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse MOG
Gly29-Gly153
Accession # Q61885
Specificity
Detects mouse MOG in direct ELISAs and Western blots. In direct ELISAs, less than 40% cross-reactivity with recombinant human MOG is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
MOG
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Immunohistochemistry 5-15 ug/mL
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF2439 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MOG Antibody [Unconjugated]

  • MGC26137
  • MOG Ig-AluB
  • MOG
  • MOGIG2
  • myelin oligodendrocyte glycoprotein
  • myelin-oligodendrocyte glycoprotein

Background

Mouse MOG is an integral membrane protein belonging to the immunoglobulin superfamily. It is found exclusively on myelinating oligodendrocytes in the central nervous system. The amino-terminal extracellular domain of mouse MOG shares 97% and 92% amino acid sequence identity with the corresponding regions of rat and human MOG, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MOG Antibody (AF2439)(7)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: ICC, IHC, IHC-Fr.


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ICC
(1)
IHC
(2)
IHC-Fr
(1)
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Mouse
(4)
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Showing Publications 1 - 7 of 7.
Publications using AF2439 Applications Species
Geoffrey D. Keeler, Cristina D. Gaddie, Addelynn S. Sagadevan, Kevin G. Senior, Isabelle Côté, Michaela Rechdan et al. Induction of antigen-specific tolerance by hepatic AAV immunotherapy regardless of T cell epitope usage or mouse strain background Molecular Therapy - Methods & Clinical Development 2023-03-09 [PMID: 36700122]
Yiyoung Kim, Eun Ji Roh, Hari Prasad Joshi, Hae Eun Shin, Hyemin Choi, Su Yeon Kwon et al. Bazedoxifene, a Selective Estrogen Receptor Modulator, Promotes Functional Recovery in a Spinal Cord Injury Rat Model International Journal of Molecular Sciences 2021-10-12 [PMID: 34681670]
Alerie G. de la Fuente, Rayner M.L. Queiroz, Tanay Ghosh, Christopher E. McMurran, Juan F. Cubillos, Dwight E. Bergles et al. Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing Molecular & Cellular Proteomics 2020-11-23 [PMID: 32434922]
Colakoglu G, Bergstrom-Tyrberg U, Berglund E, Ranscht B Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system. Proc Natl Acad Sci U S A, 2014-01-02;111(3):E394-403. 2014-01-02 [PMID: 24385581] (IHC, Mouse) IHC Mouse
Ahn , Bum Ju, Le , Hoang, Shin , Min Wook, Bae , Sung-Jin, Lee , Eun Ji, Wee , Hee-Jun, Cha , Jong-Ho, Lee , Hyo-Jong, Lee , Hye Shin, Kim , Jeong Hu, Kim , Chang-Ye, Seo , Ji Hae, Lo , Eng H, Jeon , Sejin, Lee , Mi-Ni, Oh , Goo Taeg, Yin , Guo Nan, Ryu , Ji-Kan, Suh , Jun-Kyu, Kim , Kyu-Won Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice. J Biol Chem, 2013-12-17;289(6):3328-38. 2013-12-17 [PMID: 24347169] (IHC, Mouse) IHC Mouse
Di Maio A, Skuba A, Himes BT In vivo imaging of dorsal root regeneration: rapid immobilization and presynaptic differentiation at the CNS/PNS border. J. Neurosci., 2011-03-23;31(12):4569-82. 2011-03-23 [PMID: 21430157] (ICC, Mouse) ICC Mouse
Xi H, Katschke KJ, Helmy KY, Wark PA, Kljavin N, Clark H, Eastham-Anderson J, Shek T, Roose-Girma M, Ghilardi N, van Lookeren Campagne M Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1. J. Exp. Med., 2009-12-28;207(1):7-16, S1-5. 2009-12-28 [PMID: 20038601] (IHC-Fr, Mouse) IHC-Fr Mouse

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Bioinformatics

Gene Symbol MOG
Uniprot