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MBL Antibody

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA(Cap)
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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MBL Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human MBL
Glu21-Ile248
Accession # AAH96182
Specificity
Detects human MBL in ELISAs and Western blots. In sandwich ELISAs, less than 0.05% cross-reactivity with recombinant mouse (rm) MBL and rmMBL‑2 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
MBL2
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • Western Blot 0.1 ug/mL
Application Notes
ELISA Capture:Human MBL Antibody (Catalog # AF2307)
ELISA Detection: Human MBL Biotinylated Antibody (Catalog # BAF2307)
Standard: Recombinant Human MBL (Catalog # 2307-MB)
Publications
Read Publications using
AF2307 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MBL Antibody

  • COLEC1
  • COLEC1collectin-1
  • Collectin-1
  • HSMBPC
  • Mannan-binding protein
  • mannose-binding lectin (protein C) 2, soluble (opsonic defect)
  • mannose-binding lectin (protein C) 2, soluble
  • Mannose-binding lectin
  • mannose-binding protein C
  • MBL
  • MBL2
  • MBL2D
  • MBLmannan-binding lectin
  • MBP
  • MBP1
  • MBP1mannose-binding lectin 2, soluble (opsonic defect)
  • MBP-C
  • MGC116832
  • MGC116833

Background

MBL belongs to the collectin family of innate immune defense proteins, which bind to an array of carbohydrate patterns on pathogen surfaces. MBL homotrimerizes to form a structural unit that further associates into oligomeric structures. Circulating MBL is complexed with three MBL-associated serine proteases (MASPs). Human MBL shares approximately 60% amino acid sequence identity with mouse MBL1 or MBL2.

     

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MBL Antibody (AF2307)(9)

We have publications tested in 2 confirmed species: Human, Bacteria - Moraxella catarrhalis.

We have publications tested in 4 applications: ELISA Development, Flow Cytometry, Neutralization, Western Blot.


Filter By Application
ELISA Development
(2)
Flow Cytometry
(1)
Neutralization
(2)
Western Blot
(1)
All Applications
Filter By Species
Human
(5)
Bacteria - Moraxella catarrhalis
(1)
All Species
Showing Publications 1 - 9 of 9.
Publications using AF2307 Applications Species
Michael Hultström, Michael Hultström, Barbro Eriksson, Barbro Persson, Kristina Nilsson Lipcsey, Kristina Nilsson Nilsson et al. Mannose-Binding Lectin is Associated with Thrombosis and Coagulopathy in Critically Ill COVID-19 Patients Thrombosis and Haemostasis 2020-12-01 [PMID: 32871607]
F Wang, Y Li, C Yang, Y Mu, Y Wang, W Zhang, Y Yang, C Chen, S Song, Z Shen, W Wang, J Li, J Zhai, K Guo, R Sun, L Yu, M Wang Mannan-Binding Lectin Suppresses Peptidoglycan-Induced TLR2 Activation and Inflammatory Responses Mediators Inflamm., 2019-01-09;2019(0):1349784. 2019-01-09 [PMID: 30728747] (Neutralization, Human) Neutralization Human
Jana Řimnáčová, Libor Mikeš, Libuše Turjanicová, Jana Bulantová, Petr Horák Changes in surface glycosylation and glycocalyx shedding in Trichobilharzia regenti (Schistosomatidae) during the transformation of cercaria to schistosomulum PLOS ONE 3/15/2017 [PMID: 28296924]
Liu G, Gradstedt H, Ermert D, Englund E, Singh B, Su Y, Johansson M, Aspberg A, Agarwal V, Riesbeck K, Blom A Moraxella catarrhalis Evades Host Innate Immunity via Targeting Cartilage Oligomeric Matrix Protein. J Immunol, 2015-12-28;196(3):1249-58. 2015-12-28 [PMID: 26712944] (Flow Cytometry, Bacteria - Moraxella catarrhalis) Flow Cytometry Bacteria - Moraxella catarrhalis
Wang M, Wang F, Yang J, Zhao D, Wang H, Shao F, Wang W, Sun R, Ling M, Zhai J, Song S Mannan-binding lectin inhibits Candida albicans-induced cellular responses in PMA-activated THP-1 cells through Toll-like receptor 2 and Toll-like receptor 4. PLoS ONE, 2013-12-31;8(12):e83517. 2013-12-31 [PMID: 24391778] (Neutralization, Human) Neutralization Human
Jusko M, Potempa J, Karim AY, Ksiazek M, Riesbeck K, Garred P, Eick S, Blom AM A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system. J. Immunol., 2012-01-27;188(5):2338-49. 2012-01-27 [PMID: 22287711] (ELISA Development, Human) ELISA Development Human
Mika A, Goh P, Holt DC Scabies mite peritrophins are potential targets of human host innate immunity. PLoS Negl Trop Dis, 2011-09-27;5(9):e1331. 2011-09-27 [PMID: 21980545] (Western Blot, Human) Western Blot Human
Skliris A, Happonen KE, Terpos E, Labropoulou V, Borset M, Heinegard D, Blom AM, Theocharis AD Serglycin inhibits the classical and lectin pathways of complement via its glycosaminoglycan chains: implications for multiple myeloma. Eur. J. Immunol., 2010-12-30;41(2):437-49. 2010-12-30 [PMID: 21268013] (ELISA Development, Human) ELISA Development Human
Kaisa E. Happonen, Tore Saxne, Anders Aspberg, Matthias Mörgelin, Dick Heinegård, Anna M. Blom Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis Arthritis & Rheumatism 2015-09-15 [PMID: 20737467]

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Bioinformatics

Gene Symbol MBL2
Uniprot