MMP-2 Antibody (2C1) - (Pro and Active) - BSA Free

MMP2 (matrix metalloproteinase-2; CLG4A) is a ubiquitinous metalloproteinase enzyme belonging to peptidase M10A family which is implicated in versatile activities including vasculature remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. Besides degrading proteins in the extracellular matrix, MMP2 also acts on various nonmatrix proteins such as big endothelial 1, beta-type CGRP promoting vasoconstriction, KISS etc. MMP2 plays a key role in myocardial cell death pathways and also contributes to myocardial oxidative stress through regulation of GSK3-beta activity. PKC facilitates MDM2 phosphorylation which is crucial to its enzymatic activity. MMP2 propeptide is processed by MMP14/MT-MMP1 and MMP16/MT-MMP3, and a C-terminal autocatalytic cleavage generates PEX chain which exerts anti-angiogenic as well as anti-cancer properties alongwith inhibiting cell migration or cell adhesion to FGF2/vitronectin. MMP2's isoform 2 facilitates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of pro-inflammatory NFkB, NFAT and IRF transcriptional pathways. MMP2 is implicated in several pathologies including metastasis of cancer and defects in MMP2 have been linked to Torg-Winchester syndrome (TWS) which is also called as multicentric osteolysis nodulosis and arthropathy (MONA).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Rat, Guinea Pig.

We have publications tested in 3 applications: ICC/IF, IHC-P, WB.

Showing Publications 1 - 7 of 7.

Publications using NB200-113	Applications	Species
Najjar R Raspberry Polyphenols Target Molecular Pathways of Heart Failure Thesis 2023-01-01
Xiang A, Peng Z, He H et al. The potential of brimonidine for myopia treatment: Targeting MMP-2 to regulate choroidal thickness and control eye growth Heliyon 2024-09-04 [PMID: 39309849]
Yu T, Xie X, Wei H et al. Electroacupuncture Improves Choroidal Blood Flow to Inhibit the Development of Lens-Induced Myopia in Guinea Pigs Evidence-Based Complementary and Alternative Medicine 2022-06-24 [PMID: 35783515] (WB, Guinea Pig)	WB	Guinea Pig
Schilling BK, Schusterman MA 2nd, Kim DY et al. Adipose-derived stem cells delay muscle atrophy after peripheral nerve injury in the rodent model Muscle Nerve 2019-01-26 [PMID: 30681163] (ICC/IF, Rat)	ICC/IF	Rat
Scheede-Bergdahl C, Bergdahl A, Schjerling P et al. Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes Diab Vasc Dis Res. 2014-06-04 [PMID: 24903024] (WB, Human) Details: MMP2 antibody used for WB (1:1000 dilution) on human skeletal muscle lysates from type 2 diabetes patients (T2DM / NIDDM) and control subjects (Full Text has detailed method on tissue lysis). Antibody detected the 72 kDa band of pro-MMP-2 and 62 kDa band of active-MMP-2 (Figure 3)	WB	Human
Xu H, Zhang Y, Sun H et al. Effects of Acupuncture at GV20 and ST36 on the Expression of Matrix Metalloproteinase 2, Aquaporin 4, and Aquaporin 9 in Rats Subjected to Cerebral Ischemia/Reperfusion Injury. PLoS ONE. 2014-05-15 [PMID: 24828425] (IHC-P, WB, Rat)	IHC-P, WB	Rat
Rork TH, Hadzimichalis NM, Kappil MA, Merrill GF. Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium. J Mol Cell Cardiol 40(4):553-61. 2006-04-01 [PMID: 16530785] (WB, Guinea Pig)	WB	Guinea Pig

Array NB200-113

• MMP-2 Antibodies
• MMP-2 ELISA Kits
• MMP-2 Lysate
• MMP-2 Proteins
• MMP-2 ELISAs
• MMP-2 Proteins and Enzymes