MMP-12 Antibody (82902)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

MMP-12, also known as macrophage elastase, is a zinc and calcium dependent endopeptidase expressed constitutively in macrophages and can be induced in monocytes. MMP-12 can degrade a broad spectrum of substrates, including type IV collagen, fibronectin, laminin, vitronectin, proteoglycans, chondroitin sulfate, myelin basic protein, alpha 1-antitrypsin, and plasminogen. It can also activate MMP-2 and MMP-3. The MMP-12 precursor consists of a pro domain, a catalytic domain containing the zinc-binding site, and a C-terminal hemopexin-like domain.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: Flow Cytometry, IHC, Immunoprecipitation, Neutralization, Western Blot.

Showing Publications 1 - 10 of 10.

Publications using MAB919	Applications	Species
M?ynarczyk, G;Tokarzewicz, A;Gudowska-Sawczuk, M;Mroczko, B;Novák, V;Novák, A;Mitura, P;Romanowicz, L; MMP-14 Exhibits Greater Expression, Content and Activity Compared to MMP-15 in Human Renal Carcinoma International journal of molecular sciences 2024-07-25 [PMID: 39125675] (Western Blot, Human)	Western Blot	Human
M Asakage, Y Usui, N Nezu, H Shimizu, K Tsubota, K Umazume, N Yamakawa, T Umezu, H Suwanai, M Kuroda, H Goto Comprehensive Gene Analysis of IgG4-Related Ophthalmic Disease Using RNA Sequencing J Clin Med, 2020-10-27;9(11):. 2020-10-27 [PMID: 33121169] (IHC, Human)	IHC	Human
Marina Beltrami-M, Amélie Vromman, Galina K Sukhova, Eduardo J Folco, Peter Libby Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling. PLoS ONE, 2016-03-31;0(0):1932-6203. 2016-03-31 [PMID: 27032103] (Western Blot, Human)	Western Blot	Human
Sandra Founds, Xuemei Zeng, David Lykins, James M. Roberts Developing Potential Candidates of Preclinical Preeclampsia International Journal of Molecular Sciences 2015-11-13 [PMID: 26580600]
Wang P, Chen S, Hung W, Paul C, Zhu F, Guan P, Huso D, Kontrogianni-Konstantopou A, Konstantopoulos K Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways. Oncogene, 2014-12-01;34(35):4558-69. 2014-12-01 [PMID: 25435370] (IHC, Neutralization, Human)	IHC, Neutralization	Human
Kong MY, Gaggar A, Li Y Matrix metalloproteinase activity in pediatric acute lung injury. Int J Med Sci, 2008-12-16;6(1):9-17. 2008-12-16 [PMID: 19159011] (Western Blot, Human)	Western Blot	Human
Dean RA, Cox JH, Bellac CL, Doucet A, Starr AE, Overall CM Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood, 2008-07-25;112(8):3455-64. 2008-07-25 [PMID: 18660381] (Western Blot, Human)	Western Blot	Human
Coury F, Annels N, Rivollier A, Olsson S, Santoro A, Speziani C, Azocar O, Flacher M, Djebali S, Tebib J, Brytting M, Egeler RM, Rabourdin-Combe C, Henter JI, Arico M, Delprat C Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. Nat. Med., 2007-12-23;14(1):81-7. 2007-12-23 [PMID: 18157139] (Flow Cytometry, Human)	Flow Cytometry	Human
Rust R, Kluiver J, Visser L, Harms G, Blokzijl T, Kamps W, Poppema S, Van Den Berg A Gene expression analysis of dendritic/Langerhans cells and Langerhans cell histiocytosis. J. Pathol., 2006-08-01;209(4):474-83. 2006-08-01 [PMID: 16718746] (IHC, Human)	IHC	Human
Lavigne MC, Thakker P, Gunn J, Miyashiro JS, Wasserman AM, Wei SQ, Pelker JW Human bronchial epithelial cells express and secrete MMP-12. Biochem. Biophys. Res. Commun., 2004-11-12;324(2):534-46. 2004-11-12 [PMID: 15474460] (Immunoprecipitation, Human)	Immunoprecipitation	Human

Array MAB919

• MMP-12 Antibodies
• MMP-12 ELISA Kits
• MMP-12 Kit
• MMP-12 Proteins and Enzymes