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MKP-1/DUSP1 Antibody (408612)

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MKP-1 was detected in immersion fixed paraffin-embedded sections of human prostate using Rat Anti-Human MKP-1 Monoclonal Antibody (Catalog # MAB7168) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei and cytoplasm of epithelial cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
MKP-1 was detected in immersion fixed paraffin-embedded sections of human prostate using Rat Anti-Human MKP-1 Monoclonal Antibody (Catalog # MAB7168) at 15 µg/mL overnight at 4 °C. Before incubation with the primary ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
408612
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price
Carrier Free
MAB7168-SP
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MKP-1/DUSP1 Antibody (408612) Summary

Immunogen
E. coli-derived recombinant human MKP-1
Met1-Cys367
Accession # P28562
Specificity
Detects human MKP-1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) MKP-2, rhMKP-3, or rhMKP-5 is observed.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
DUSP1
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 8-25 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MKP-1/DUSP1 Antibody (408612)

  • CL100
  • CL100MAP kinase phosphatase 1
  • dual specificity phosphatase 1
  • Dual specificity protein phosphatase hVH1
  • DUSP1
  • EC 3.1.3.16
  • EC 3.1.3.48
  • HVH1
  • Mitogen-activated protein kinase phosphatase 1
  • MKP1
  • MKP-1
  • MKP-1dual specificity protein phosphatase 1
  • Protein-tyrosine phosphatase CL100
  • PTPN10
  • PTPN10serine/threonine specific protein phosphatase
  • VH1

Background

MKP-1, also known as PTPN10, DUSP1, and CL100, is an approximately 45 kDa Ser/Thr protein phosphatase that dephosphorylates p38 MAPK and JNK. Acetylation of MKP-1 enhances this activity and limits the inflammation-induced signaling downstream of TLR proteins. Within aa 1-367, human MKP-1 shares 97% aa sequence identity with mouse and rat MKP-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol DUSP1
Uniprot