Species: Hu, Mu, Rt
Applications: WB, Flow, IHC, IP
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt, Bv, Ca
Applications: WB, ELISA, IHC
Host: Goat Polyclonal
Species: Hu
Applications: IHC
Host: Rat Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Bioinformatics
| Entrez |
Human
Mouse
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
1843 |
| Alternate Names |
- CL100MAP kinase phosphatase 1
- dual specificity phosphatase 1
- Dual specificity protein phosphatase hVH1
- EC 3.1.3.16
- EC 3.1.3.48
- HVH1
- Mitogen-activated protein kinase phosphatase 1
- MKP1
- MKP-1dual specificity protein phosphatase 1
- Protein-tyrosine phosphatase CL100
- PTPN10serine/threonine specific protein phosphatase
- VH1
|
