MAP3K12 Antibody

Mitogen-activated protein kinase kinase kinase 12 (MAP3K12) is a MAP kinase kinase kinase enzyme belonging to the serine/threonine protein kinase family. Located on human chromosome 12q13, it regulates the activity of various MAPKKs such as MAPKK7 and hence activating C-Jun N-terminal Kinase (JNK/SAPK). MAP3K12 associates with scaffold proteins, JIPs, which also interacts with MAPKK7 and JNK/SAPK. MAP3K12 protein is associated with dotted structures that are regularly located with golgi apparatus and also along the microtubules. This protein contains two leucine-zipper-like motifs and interaction of MAP3K12-binding inhibitory protein with one of these motifs deactivates this protein and induces activation of SAPK/JNK. MAP3K12 is also implicated in regulating radial cell migration via microtubule-based events. It has been reported that ectopic expression of this protein in neuronal precursor cells allows these cells to migrate from the ventricular zone and differentiate into neural cells. MAP3K12 was identified as a signaling molecule that is required for the regulation of keratinocyte terminal differentiation and cornification. While MAP3K12 is found in the epidermis, it is highly restricted to the neuronal cells in the central, peripheral and autonomic nervous systems. More specifically, it is localized in the axons of these cells. It has been shown that over-expression of MAP3K12 in cos-1 cells impairs the radial organization of microtubules without massive depolymerization. In humans, MAP3K12 is approximately a 68kDa protein (567 amino acids). In rat and mouse this protein weighs 107kDa (888 amino acids).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 6 of 6.

Publications using NBP1-46063	Applications	Species
[PMID: 15749080]. Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo Gene Expr Patterns 2005-04-01 [PMID: 15749080] Details: This citation used the FITC version of this antibody.
Robitaille H, Proulx R, Robitaille K et al. The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation J Biol Chem [PMID: 15695824] Details: Used the FITC form of this antibody.
Hirai S, Kawaguchi A, Hirasawa R et al. MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo Development 2002-10-01 [PMID: 12223406] Details: This citation used the FITC version of this antibody.
Fukuyama K, Yoshida M, Yamashita A. MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase J Biol Chem [PMID: 10801814] Details: Used the FITC form of this antibody.
Ito M, Yoshioka K, Akechi M. JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway Mol Cell Biol [PMID: 10523642] Details: Used the FITC form of this antibody.
Douziech M, Laberge G, Grondin G et al. Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells J Histochem Cytochem 1999-10-01 [PMID: 10490457] Details: This citation used the FITC version of this antibody.

Array NBP1-46063

• MAP3K12 Antibodies
• MAP3K12 Proteins