MAP3K12 Products

Description

The protein encoded by the MAP3K12 gene is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. (provided by RefSeq)

Bioinformatics

Entrez	7786 Human
Uniprot	AAH50050 Human NP_006292 Human Q12852 Human
Product By Gene ID	7786
Alternate Names	DLKEC 2.7.11.25 Dual leucine zipper bearing kinase EC 2.7.11 Leucine-zipper protein kinase MAPK-upstream kinase MEKK12 mitogen-activated protein kinase kinase kinase 12 Mixed lineage kinase MUKdual leucine zipper kinase DLK protein kinase MUK ZPKleucine zipper protein kinase ZPKP1

Research Areas for MAP3K12

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Protein Kinase