LYVE-1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Lymphatic vessel endothelial hyaluronan (HA) receptor-1 (LYVE-1) is a receptor of HA, a linear high molecular weight polymer composed of alternating units of D‑glucuronic acid and N-acetyl-D-glucosamine. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease (1). The turnover of HA (several grams/day in humans) occurs primarily in the lymphatics and liver, the two major clearance systems that catabolize approximately 85% and 15% of HA, respectively (1-3). LYVE-1 shares 41% homology with the other known HA receptor, CD44 (4). The homology between the two proteins increases to 61% within the HA binding domain. The HA binding domain, known as the link module, is a common structural motif found in other HA binding proteins such as link protein, aggrecan and versican (1, 5). Human and mouse LYVE-1 share 69% amino acid sequence identity.

LYVE-1 is primarily expressed on both the luminal and abluminal surfaces of lymphatic vessels (4, 5). In addition, LYVE-1 is also present in normal hepatic blood sinusoidal endothelial cells (6). LYVE-1 mediates the endocytosis of HA and may transport HA from tissue to lymph by transcytosis, delivering HA to lymphatic capillaries for removal and degradation in the regional lymph nodes (5, 7, 8). Because of its restricted expression patterns, LYVE-1, along with other lymphatic proteins such as VEGF R3, podoplanin and the homeobox protein propero-related (Prox-1), constitute a set of markers useful for distinguishing between lymphatic and blood microvasculature (4, 5, 9-11).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 6 confirmed species: Human, Mouse, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Rabbit, Xenograft.

We have publications tested in 8 applications: Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, Immunohistochemistry, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 41. Show All 41 Publications. Collapse Publications.

Publications using AF2089	Applications	Species
Fitzpatrick, Z;Ghabdan Zanluqui, N;Rosenblum, JS;Tuong, ZK;Lee, CYC;Chandrashekhar, V;Negro-Demontel, ML;Stewart, AP;Posner, DA;Buckley, M;Allinson, KSJ;Mastorakos, P;Chittiboina, P;Maric, D;Donahue, D;Helmy, A;Tajsic, T;Ferdinand, JR;Portet, A;Peñalver, A;Gillman, E;Zhuang, Z;Clatworthy, MR;McGavern, DB; Venous-plexus-associated lymphoid hubs support meningeal humoral immunity Nature 2024-03-20 [PMID: 38509366] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Yoon C, Lu J, Jun Y et al. KRAS activation in gastric cancer stem-like cells promotes tumor angiogenesis and metastasis BMC cancer 7/22/2023 [PMID: 37481516]
Egozi, A;Olaloye, O;Werner, L;Silva, T;McCourt, B;Pierce, RW;An, X;Wang, F;Chen, K;Pober, JS;Shouval, D;Itzkovitz, S;Konnikova, L; Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis PLoS biology 2023-05-19 [PMID: 37205711] (IHC, Human)	IHC	Human
Stock AT, Parsons S, Sharma VJ et al. Intimal macrophages develop from circulating monocytes during vasculitis Clinical & translational immunology 8/13/2022 [PMID: 35991774]
RE Niec, T Chu, M Schernthan, S Gur-Cohen, L Hidalgo, HA Pasolli, KA Luckett, Z Wang, SR Bhalla, F Cambuli, RP Kataru, K Ganesh, BJ Mehrara, D Pe'er, E Fuchs Lymphatics act as a signaling hub to regulate intestinal stem cell activity Cell Stem Cell, 2022-06-20;29(7):1067-1082.e18. 2022-06-20 [PMID: 35728595] (IHC, Human)	IHC	Human
O Meçe, D Houbaert, ML Sassano, T Durré, H Maes, M Schaaf, S More, M Ganne, M García-Cab, M Borri, J Verhoeven, M Agrawal, K Jacobs, G Bergers, S Blacher, B Ghesquière, M Dewerchin, JV Swinnen, S Vinckier, MS Soengas, P Carmeliet, A Noël, P Agostinis Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis Nature Communications, 2022-05-19;13(1):2760. 2022-05-19 [PMID: 35589749] (Western Blot, Human)	Western Blot	Human
Jesus Maria Gómez-Salinero, Franco Izzo, Yang Lin, Sean Houghton, Tomer Itkin, Fuqiang Geng et al. Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction Cell Stem Cell 4/1/2022 [PMID: 35364013]
BJ Mehrara, HJ Park, RP Kataru, J Bromberg, M Coriddi, JE Baik, J Shin, C Li, MR Cavalli, EM Encarnacio, M Lee, KJ Van Zee, E Riedel, JH Dayan Pilot Study of Anti-Th2 Immunotherapy for the Treatment of Breast Cancer-Related Upper Extremity Lymphedema Biology, 2021-09-18;10(9):. 2021-09-18 [PMID: 34571811] (IHC, Human)	IHC	Human
I Grierson, D Minckler, MK Rippy, AJ Marshall, N Collignon, J Bianco, B Detry, MA Johnstone A novel suprachoroidal microinvasive glaucoma implant: in vivo biocompatibility and biointegration BMC Biomed Eng, 2020-10-14;2(0):10. 2020-10-14 [PMID: 33073174] (IHC, Rabbit)	IHC	Rabbit
Yifan Wu, Young Jin Seong, Kin Li, Dongwon Choi, Eunkyung Park, George H. Daghlian et al. Organogenesis and distribution of the ocular lymphatic vessels in the anterior eye JCI Insight 7/9/2020 [PMID: 32641580]
Quincy C. C. van den Bosch, Jackelien G. M. van Beek, Emine Kiliç, Robert M. Verdijk Transient Expression of Lymphatic Markers in Retrobulbar Intraconal Orbital Vasculature During Fetal Development Investigative Opthalmology & Visual Science 6/10/2020 [PMID: 32516408]
Ying Wang, Thomas S Chaffee, Rebecca S LaRue, Danielle N Huggins, Patrice M Witschen, Ayman M Ibrahim et al. Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice eLife 6/1/2020 [PMID: 32479261]
Y Yoshimatsu, S Kimuro, J Pauty, K Takagaki, S Nomiyama, A Inagawa, K Maeda, KA Podyma-Ino, K Kajiya, YT Matsunaga, T Watabe TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals PLoS ONE, 2020-05-01;15(5):e0232356. 2020-05-01 [PMID: 32357159] (IHC, Human)	IHC	Human
TA Stanly, M Fritzsche, S Banerji, D Shrestha, F Schneider, C Eggeling, DG Jackson The cortical actin network regulates avidity-dependent binding of hyaluronan by the Lymphatic Vessel Endothelial receptor LYVE-1 J. Biol. Chem., 2020-02-07;0(0):. 2020-02-07 [PMID: 32034091] (Immunoprecipitation, Human)	Immunoprecipitation	Human
CZ Li, YX Lin, TC Huang, JY Pan, GX Wang Receptor-Interacting Protein Kinase 1 Promotes Cholangiocarcinoma Proliferation And Lymphangiogenesis Through The Activation Protein 1 Pathway Onco Targets Ther, 2019-11-01;12(0):9029-9040. 2019-11-01 [PMID: 31806991] (IHC-P, Xenograft)	IHC-P	Xenograft
Jackelien G. M. van Beek, Quincy C. C. van den Bosch, Nicole Naus, Dion Paridaens, Annelies de Klein, Emine Kiliç et al. Absence of Intraocular Lymphatic Vessels in Uveal Melanomas with Extrascleral Growth Cancers (Basel) 2/15/2019 [PMID: 30781402]
MM Sun, AM Chan, SM Law, S Duarte, D Diaz-Aguil, M Wadehra, LK Gordon Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model Invest. Ophthalmol. Vis. Sci., 2019-01-02;60(1):245-254. 2019-01-02 [PMID: 30646013] (IHC, Human)	IHC	Human
SATOMI ARIMOTO, TAKUMI HASEGAWA, DAISUKE TAKEDA, IZUMI SAITO, RIKA AMANO, MASAYA AKASHI et al. Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma Anticancer Research 11/1/2018 [PMID: 30396932]
SKC Ganchua, AM Cadena, P Maiello, HP Gideon, AJ Myers, BF Junecko, EC Klein, PL Lin, JT Mattila, JL Flynn Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques PLoS Pathog., 2018-11-01;14(11):e1007337. 2018-11-01 [PMID: 30383808] (IHC, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque))	IHC	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque)
YR Wen, JH Yang, X Wang, ZB Yao Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease Neural Regen Res, 2018-04-01;13(4):709-716. 2018-04-01 [PMID: 29722325] (IHC, Mouse)	IHC	Mouse
R Yuge, Y Kitadai, H Takigawa, T Naito, N Oue, W Yasui, S Tanaka, K Chayama Silencing of Discoidin Domain Receptor-1 (DDR1) Concurrently Inhibits Multiple Steps of Metastasis Cascade in Gastric Cancer Transl Oncol, 2018-03-13;11(3):575-584. 2018-03-13 [PMID: 29547756] (IHC-P, Human)	IHC-P	Human
C Cochain, E Vafadarnej, P Arampatzi, P Jaroslav, H Winkels, K Ley, D Wolf, AE Saliba, A Zernecke Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis Circ. Res., 2018-03-15;0(0):. 2018-03-15 [PMID: 29545365] (IHC-P, Human)	IHC-P	Human
I Mitrofanov, M Zavyalova, V Riabov, N Cherdyntse, J Kzhyshkows The effect of neoadjuvant chemotherapy on the correlation of tumor-associated macrophages with CD31 and LYVE-1 Immunobiology, 2017-10-31;0(0):. 2017-10-31 [PMID: 29459011] (IHC-P, Human)	IHC-P	Human
JM Nesgaard, BV Stimec, P Soulie, B Edwin, A Bakka, D Ignjatovic Defining minimal clearances for adequate lymphatic resection relevant to right colectomy for cancer: a post-mortem study Surg Endosc, 2018-02-12;0(0):. 2/12/2018 [PMID: 29435757]
R Hägerling, D Drees, A Scherzinge, C Dierkes, S Martin-Alm, S Butz, K Gordon, M Schäfers, K Hinrichs, P Ostergaard, D Vestweber, T Goerge, S Mansour, X Jiang, PS Mortimer, F Kiefer VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations JCI Insight, 2017-08-17;2(16):. 2017-08-17 [PMID: 28814672] (IHC-Fr, Human)	IHC-Fr	Human
LD Volk-Drape, KL Hall, AC Wilber, S Ran Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4 PLoS ONE, 2017-06-09;12(6):e0179257. 2017-06-09 [PMID: 28598999] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
TGF-?1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT) PLoS ONE, 2016-09-02;11(9):e0162221. 2016-09-02 [PMID: 27589056] (Western Blot, Human)	Western Blot	Human
Riordan D, Varma S, West R, Brown P Automated Analysis and Classification of Histological Tissue Features by Multi-Dimensional Microscopic Molecular Profiling. PLoS ONE, 2015-07-15;10(7):e0128975. 2015-07-15 [PMID: 26176839] (IHC-P, Human)	IHC-P	Human
Aikaterini Evangelia Moustou, Paraskevi Alexandrou, Alexander J Stratigos, Ioanna Giannopoulou, Theognosia Vergou, Andreas Katsambas et al. Expression of lymphatic markers and lymphatic growth factors in psoriasis before and after anti-TNF treatment* Anais Brasileiros de Dermatologia 12/1/2014 [PMID: 25387493]
Sanjeev A. Datar, Peter E. Oishi, Wenhui Gong, Stephen H. Bennett, Christine E. Sun, Michael Johengen et al. Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow American Journal of Physiology-Heart and Circulatory Physiology 4/1/2014 [PMID: 24531811]
Berenguer-Daize C, Boudouresque F, Bastide C, Tounsi A, Benyahia Z, Acunzo J, Dussault N, Delfino C, Baeza N, Daniel L, Cayol M, Rossi D, El Battari A, Bertin D, Mabrouk K, Martin P, Ouafik L Adrenomedullin blockade suppresses growth of human hormone-independent prostate tumor xenograft in mice. Clin Cancer Res, 2013-10-07;19(22):6138-50. 2013-10-07 [PMID: 24100627] (IHC, Human)	IHC	Human
Yang-Kyu Choi, Beth A. Fallert Junecko, Cynthia R. Klamar, Todd A. Reinhart Characterization of cells expressing lymphatic marker LYVE-1 in macaque large intestine during simian immunodeficiency virus infection identifies a large population of nonvascular LYVE-1(+)/DC-SIGN(+) cells Lymphatic Research and Biology 3/28/2013 [PMID: 23531182]
Xiaoke Yin, Marshall Bern, Qiuru Xing, Jenny Ho, Rosa Viner, Manuel Mayr Glycoproteomic Analysis of the Secretome of Human Endothelial Cells* Molecular & Cellular Proteomics 4/1/2013 [PMID: 23345538]
Servais EL, Suzuki K, Colovos C An in vivo platform for tumor biomarker assessment. PLoS ONE, 2011-10-26;6(10):e26722. 2011-10-26 [PMID: 22046338] (Flow Cytometry, IHC, Human)	Flow Cytometry, IHC	Human
MAXINE S. EMMETT, SILVIA LANATI, DARRYL B.A. DUNN, OLIVER A. STONE, DAVID O. BATES CCR7 Mediates Directed Growth of Melanomas Towards Lymphatics Microcirculation 1/6/2012 [PMID: 21166932]
Mila Volchek, Jane E Girling, Gendie E Lash, Leonie Cann, Beena Kumar, Stephen C Robson et al. Lymphatics in the human endometrium disappear during decidualization Human Reproduction 10/1/2010 [PMID: 20729537]
Jane E Girling, Jacqueline F Donoghue, Fiona L Lederman, Leonie M Cann, Marc G Achen, Steven A Stacker et al. Vascular endothelial growth factor-D over-expressing tumor cells induce differential effects on uterine vasculature in a mouse model of endometrial cancer Reproductive Biology and Endocrinology 7/8/2010 [PMID: 20615255]
Maxine S Emmett, Kirsty E Symonds, Howard Rigby, Martin G Cook, Rebecca Price, Chris Metcalfe et al. Prediction of melanoma metastasis by the Shields index based on lymphatic vessel density BMC Cancer 12/1/2010 [PMID: 20478045]
Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, Stowell SA, Borisenko V, Feirt N, Podgrabinska S, Shiraishi K, Chawengsaksophak K, Rossant J, Accili D, Skobe M, Kitajewski J Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J. Clin. Invest., 2007-11-01;117(11):3369-82. 2007-11-01 [PMID: 17948123] (ICC, IHC, Human, Mouse)	ICC, IHC	Human, Mouse
Kivela R, Silvennoinen M, Lehti M, Kainulainen H, Vihko V Effects of acute exercise, exercise training, and diabetes on the expression of lymphangiogenic growth factors and lymphatic vessels in skeletal muscle. Am. J. Physiol. Heart Circ. Physiol., 2007-08-31;293(4):H2573-9. 2007-08-31 [PMID: 17766486] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Silverman MD, Haas CS, Rad AM, Arbab AS, Koch AE The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium. Arthritis Rheum., 2007-06-01;56(6):1817-26. 2007-06-01 [PMID: 17530710] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Show All 41 Publications. Collapse Publications.

Array AF2089

• LYVE-1 Antibodies
• LYVE-1 Antibody Pack
• LYVE-1 Lysate
• LYVE-1 Proteins
• LYVE-1 Proteins and Enzyme
• LYVE-1 ELISA