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Lyp/PTPN22 Antibody

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Immunohistochemistry-Paraffin: Lyp/PTPN22 Antibody [NBP1-81277] - Staining of human lymph node shows stark cytoplasmic positivity in a subset of germinal center cells and non-germinal center cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Lyp/PTPN22 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: SEISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEGCSNSKPVNAAGRYFNSKVPITRTKS
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTPN22
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
Application Notes
HIER pH6 retrieval is recommended.
Control Peptide
Lyp/PTPN22 Protein (NBP1-81277PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Lyp/PTPN22 Antibody

  • EC 3.1.3.48
  • Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
  • Lymphoid phosphatase
  • lymphoid-specific protein tyrosine phosphatase
  • Lyp
  • Lyp1
  • Lyp2
  • LyPTP
  • PEP
  • PEST-domain phosphatase
  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
  • protein tyrosine phosphatase, non-receptor type 8
  • PTPN22
  • PTPN8 (former)
  • PTPN8LYP1
  • tyrosine-protein phosphatase non-receptor type 22

Background

PTPN22 encodes a protein tyrosine phosphatase which is expressed primarily in lymphoid tissues. This enzyme associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PTPN22