LXR alpha/NR1H3 Antibody - BSA Free

LXR-A belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-B, LXR-A forms heterodimers with the retinoic acid receptor RXRalpha, function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Human and mouse tumors produce LXR ligands that inhibit CCR7 expression on maturing dendritic cells (DCs), thereby allowing tumor immunoescape. In mouse models, it was shown that ablating LXR-A signaling led to an immune-mediated strong inhibition of tumor growth, suggesting that manipulation of this pathway may be a viable anti-cancer approach.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP1-77106	Applications	Species
Banno A, Wang J, Okada K Identification of a novel cholesterol-lowering dipeptide, phenylalanine-proline (FP), and its down-regulation of intestinal ABCA1 in hypercholesterolemic rats and Caco-2 cells Sci Rep 2019-12-19 [PMID: 31857643] (WB, Rat)	WB	Rat
Torres-Luquis O, Madden K, N'dri NM et al. LXR/RXR pathway signaling associated with triple-negative breast cancer in African American women Breast Cancer (Dove Med Press) 2019-12-20 [PMID: 30588086] (IHC-P, Human)	IHC-P	Human
Ahn SB, Jun DW, Jang K et al. Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease Korean J. Intern. Med. 2019-07-01 [PMID: 29466845] (IHC-P, Human)	IHC-P	Human
Ahn Sang Bong, Jang Kiseok, Jun Dae Won et al. Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease. Dig Dis Sci. 2014-08-08 [PMID: 25102981]

Array NBP1-77106

• LXR alpha/NR1H3 Antibodies
• LXR alpha/NR1H3 ELISA Kits
• LXR alpha/NR1H3 Lysate
• LXR alpha/NR1H3 Proteins