FXR/NR1H4 Antibody (A9033A) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Farnesoid X-activated Receptor (FXR, HRR-1, BAR, RIP14; NR1H4) is a member of the Orphan Nuclear Receptor family. FXR is expressed in the liver, intestinal villi, renal tubes and adrenal cortex. FXR is a global regulator of bile acid metabolism. Two genes, cholesterol 7a-hydroxylase (CYP7A1) and IBABP (Ileal Bile Acid Binding Protein), which are implicated in bile acid biosynthesis and recycling, respectively, are target genes of FXR. FXR is shown to be transcriptionally activated by farnesol metabolites such as farnesol itself and juvenile hormone III. FXR binds to DNA only as a heterodimer with Retinoid X Receptor (RXR).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IHC, Immunoprecipitation, Western Blot.

Showing Publications 1 - 7 of 7.

Publications using PP-A9033A-00	Applications	Species
L Absil, F Journé, D Larsimont, JJ Body, L Tafforeau, D Nonclercq Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells BMC Cancer, 2020;20(1):640. 2020 [PMID: 32650752] (IHC, Human)	IHC	Human
HM Hassan, M Isovic, B Kolendowsk, N Bauer-Mais, O Onabote, M Cecchini, A Haig, S Maleki Var, TM Underhill, J Torchia Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma Cell Rep, 2020;31(1):107475. 2020 [PMID: 32268085] (Immunoprecipitation, Mouse)	Immunoprecipitation	Mouse
Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways. Nat Med, 2012;18(11):1665-72. 2012 [PMID: 23104131] (Western Blot, Mouse)	Western Blot	Mouse
Deuschle U, Schuler J, Schulz A, Schluter T, Kinzel O, Abel U, Kremoser C FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model. PLoS ONE, 2012;7(10):e43044. 2012 [PMID: 23056173] (Western Blot, Human)	Western Blot	Human
Prade E, Tobiasch M, Hitkova I, Schaffer I, Lian F, Xing X, Tanzer M, Rauser S, Walch A, Feith M, Post S, Rocken C, Schmid RM, Ebert MP, Burgermeister E Bile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding protein. Mol. Endocrinol., 2012;26(5):819-32. 2012 [PMID: 22474125] (Western Blot, Human)	Western Blot	Human
Lian F, Xing X, Yuan G, Schafer C, Rauser S, Walch A, Rocken C, Ebeling M, Wright MB, Schmid RM, Ebert MP, Burgermeister E Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage. Biochem. J., 2011;438(2):315-23. 2011 [PMID: 21619550] (Western Blot, Human)	Western Blot	Human
Lee JY, Lee KT, Lee JK, Lee KH, Jang KT, Heo JS, Choi SH, Kim Y, Rhee JC Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion. Br. J. Cancer, 2011;104(6):1027-37. 2011 [PMID: 21364590] (Western Blot, Human)	Western Blot	Human

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Human	02/25/2015	View Summary Application Western Blot Sample Tested See PMID 23056173 Species Human Blocking Blocking Details See PMID 23056173 Details Detection Notes See PMID 23056173 Comments Comments Independent review from antibodyresource.comPublished in PMID 23056173
	5 reviewed by: Verified Customer	WB	Human	02/25/2015	View Summary Application Western Blot Sample Tested See PMID 23530060 Species Human Blocking Blocking Details See PMID 23530060 Details Detection Notes See PMID 23530060 Comments Comments Independent review from antibodyresource.comPublished in PMID 23530060

Array PP-A9033A-00

• FXR/NR1H4 Antibodies
• FXR/NR1H4 Lysate
• FXR/NR1H4 Proteins