Lumican Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Lumican is a 40 kDa member of the family of small leucine-rich repeat proteoglycans (SLRPs) and the class II subfamily (1). Human Lumican is synthesized as a 338 amino acid (aa) precursor that contains an 18 aa signal sequence and a 320 aa mature chain. The mature chain contains a negatively charged N-terminal domain containing sulfated tyrosine and disulfide bonds, 12 leucine-rich repeats (LRRs), four potential sites of N-linked glycosylation, and a carboxyl terminal domain containing two conserved cysteines (1). Mature human Lumican is 88%, 87%, and 70% aa identical to mature mouse, rat, and chick Lumican, respectively. SLRPs constitute an important fraction of noncollagenous extracellular matrix proteins (ECM) proteins (1, 2). Lumican is expressed in a variety of tissues, including skin, artery, lung, cornea, kidney, bone, aorta, and articular cartilage (1). Lumican’s role in vivo has been found using Lumican null mice. These mice have functional deficits including corneal opacity as well as skin and tendon fragility associated with disorganized and loosely packed collagen fibers (1, 3‑6). The abnormal connective tissue phenotype seen in the Lumican null mice shows the importance of the role of Lumican in collagen fibrillogenesis (1). In addition to the control of collagen fibril assembly, Lumican has been shown to play a role in the regulation of cell proliferation (7, 8), migration (8, 9), and adhesion (9). Lumican’s overexpression has been reported in carcinoid tumor, breast, colorectal, neuroendocrine, uterine cervical and pancreatic cancers (10).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Bovine.

We have publications tested in 3 applications: IHC, IHC-P, Western Blot.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using AF2846	Applications	Species
Blanco-Elices C, Morales-�lvarez C, Chato-Astrain J et al. Development of stromal differentiation patterns in heterotypical models of artificial corneas generated by tissue engineering Frontiers in Bioengineering and Biotechnology 3/23/2023 [PMID: 37034263]
F Linke, JEC Johnson, S Kern, CD Bennett, A Lourdusamy, D Lea, SC Clifford, CLR Merry, S Stolnik, MR Alexander, AC Peet, DJ Scurr, RL Griffiths, AM Grabowska, ID Kerr, B Coyle Identifying new biomarkers of aggressive Group�3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging Acta neuropathologica communications, 2023-01-11;11(1):6. 2023-01-11 [PMID: 36631900] (IHC, Human)	IHC	Human
Daniella dos Santos Courrol, Cristiane Castilho Fernandes da da Silva, Luan Gavião Prado, Rosa Maria Chura-Chambi, Ligia Morganti, Gisele Oliveira de Souza et al. Leptolysin, a Leptospira secreted metalloprotease of the pappalysin family with broad-spectrum activity Frontiers in Cellular and Infection Microbiology 8/23/2022 [PMID: 36081769]
Chao Liu, Yulian Hu, Zhongying Wang, Hua Pan, Yan Ren, Xiao Li et al. The Downregulation of Placental Lumican Promotes the Progression of Preeclampsia Reproductive Sciences 11/1/2021 [PMID: 34231169]
Ersal Türker, Fabian Garreis, Noushafarin Khajavi, Peter S. Reinach, Pooja Joshi, Tobias Brockmann et al. Vascular Endothelial Growth Factor (VEGF) Induced Downstream Responses to Transient Receptor Potential Vanilloid 1 (TRPV1) and 3-Iodothyronamine (3-T1AM) in Human Corneal Keratocytes Front Endocrinol (Lausanne) 11/22/2018 [PMID: 30524369]
X Li, Y Lee, Y Kang, B Dai, MR Perez, M Pratt, EJ Koay, M Kim, RA Brekken, JB Fleming Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma Cell Death Differ., 2018-10-03;26(2):382-393. 2018-10-03 [PMID: 30283082] (IHC, Human)	IHC	Human
Laura E. Sidney, Andrew Hopkinson Corneal keratocyte transition to mesenchymal stem cell phenotype and reversal using serum-free medium supplemented with fibroblast growth factor-2, transforming growth factor-beta 3 and retinoic acid Journal of Tissue Engineering and Regenerative Medicine 1/1/2018 [PMID: 27685949]
X Li, D Roife, Y Kang, B Dai, M Pratt, J B Fleming Extracellular lumican augments cytotoxicity of chemotherapy in pancreatic ductal adenocarcinoma cells via autophagy inhibition Oncogene 9/15/2016 [PMID: 26876211]
Loren E. Dupuis, Matthew G. Berger, Samuel Feldman, Lorna Doucette, Vennece Fowlkes, Shukti Chakravarti et al. Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly Journal of Molecular and Cellular Cardiology 7/1/2015 [PMID: 25886697]
Li X, Truty M, Kang Y, Chopin-Laly X, Zhang R, Roife D, Chatterjee D, Lin E, Thomas R, Wang H, Katz M, Fleming J Extracellular lumican inhibits pancreatic cancer cell growth and is associated with prolonged survival after surgery. Clin Cancer Res, 2014-10-21;20(24):6529-40. 2014-10-21 [PMID: 25336691] (IHC, Human)	IHC	Human
Zhang Y, Mao X, Schwend T, Littlechild S, Conrad G Resistance of corneal RFUVA-cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases. Invest Ophthalmol Vis Sci, 2013-02-05;54(2):1014-25. 2013-02-05 [PMID: 23322569] (Western Blot, Human)	Western Blot	Human
Krishnan A, Li X, Kao W, Viker K, Butters K, Masuoka H, Knudsen B, Gores G, Charlton M Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis. Lab Invest, 2012-09-24;92(12):1712-25. 2012-09-24 [PMID: 23007134] (IHC-P, Mouse)	IHC-P	Mouse
Zhang Y, Conrad AH, Conrad GW Effects of Ultraviolet-A and Riboflavin on the Interaction of Collagen and Proteoglycans during Corneal Cross-linking. J. Biol. Chem., 2011-02-18;286(15):13011-22. 2011-02-18 [PMID: 21335557] (Western Blot, Bovine)	Western Blot	Bovine
Wu J, Liu Z, Shao C, Gong Y, Hernando E, Lee P, Narita M, Muller W, Liu J, Wei JJ HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes. Cancer Res., 2011-01-11;71(2):349-59. 2011-01-11 [PMID: 21224353] (Western Blot, Human)	Western Blot	Human
Show All 14 Publications. Collapse Publications.

Array AF2846

• Lumican Antibodies
• Lumican ELISA Kit
• Lumican Lysate
• Lumican Protein
• Lumican Proteins and Enzymes
• Lumican ELISA