Lumican Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Lumican is a 40 kDa member of the family of small leucine-rich repeat proteoglycans (SLRPs) and the class II subfamily (1). Mouse Lumican is synthesized as a 338 amino acid (aa) precursor that contains an 18 aa signal sequence and a 320 aa mature chain (SwissProt #: 51885). The mature chain contains a negatively charged N‑terminal domain containing sulfated tyrosine and disulfide bonds, 12 leucine-rich repeats (LRRs), four potential sites of N-linked glycosylation, and a carboxyl terminal domain containing two conserved cysteines (1). Mature mouse Lumican is 98%, 88%, and 70% aa identical to mature rat, human, and chick Lumican, respectively. SLRPs constitute an important fraction of noncollagenous extracellular matrix proteins (ECM) proteins (1-2). Lumican is expressed in a variety of tissues, including skin, artery, lung, cornea, kidney, bone, aorta, and articular cartilage (1). Lumican’s role in vivo has been found using Lumican null mice. These mice have functional deficits including corneal opacity as well as skin and tendon fragility associated with disorganized and loosely packed collagen fibers (1, 3-6). The abnormal connective tissue phenotype seen in the Lumican null mice shows the importance of the role of Lumican in collagen fibrillogenesis (1). In addition to the control of collagen fibril assembly, Lumican has been shown to play a role in the regulation of cell proliferation (7-8), migration (8-9), and adhesion (9). Lumican’s overexpression has been reported in carcinoid tumor, breast, colorectal, neuroendocrine, uterine cervical, and pancreatic cancers (10).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: ICC, IHC, IHC-P, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using AF2745	Applications	Species
Y Itoh, V Sahni, SJ Shnider, H McKee, JD Macklis Inter-axonal molecular crosstalk via Lumican proteoglycan sculpts murine cervical corticospinal innervation by distinct subpopulations Cell Reports, 2023-03-17;42(3):112182. 2023-03-17 [PMID: 36934325] (ICC, IHC, Immunoprecipitation, Western Blot, Human, Mouse)	ICC, IHC, Immunoprecipitation, Western Blot	Human, Mouse
Pires, A, Greenshields-Watson, A Et al. Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection. Cancer Immunol Res 12/1/2020 [PMID: 33023965]
AF Asega, MC Menezes, D Trevisan-S, D Cajado-Car, L Bertholim, AK Oliveira, A Zelanis, SMT Serrano Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases Sci Rep, 2020-07-31;10(1):12912. 2020-07-31 [PMID: 32737331] (Western Blot, Mouse)	Western Blot	Mouse
Jorge López-Tello, Vicente Pérez-García, Jaspreet Khaira, Laura C Kusinski, Wendy N Cooper, Adam Andreani et al. Fetal and trophoblast PI3K p110 alpha have distinct roles in regulating resource supply to the growing fetus in mice eLife 6/26/2019 [PMID: 31241463]
HW Cheng, L Onder, M Novkovic, C Soneson, M Lütge, N Pikor, E Scandella, MD Robinson, JI Miyazaki, A Tersteegen, U Sorg, K Pfeffer, T Rülicke, T Hehlgans, B Ludewig Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp Nat Commun, 2019-04-15;10(1):1739. 2019-04-15 [PMID: 30988302] (IHC, Mouse)	IHC	Mouse
G Wolff, AE Taranko, I Meln, J Weinmann, T Sijmonsma, S Lerch, D Heide, AT Billeter, D Tews, D Krunic, P Fischer-Po, BP Müller-Sti, S Herzig, D Grimm, M Heikenwäld, WW Kao, A Vegiopoulo Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis Mol Metab, 2018-10-23;0(0):. 2018-10-23 [PMID: 30409703] (Western Blot, Mouse)	Western Blot	Mouse
Wang L, Foster B, Kram V, Nociti F, Zerfas P, Tran A, Young M, Somerman M Fibromodulin and Biglycan Modulate Periodontium through TGFbeta/BMP Signaling. J Dent Res, 2014-06-25;93(8):780-787. 2014-06-25 [PMID: 24966230] (IHC-P, Mouse)	IHC-P	Mouse
Krishnan A, Li X, Kao W, Viker K, Butters K, Masuoka H, Knudsen B, Gores G, Charlton M Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis. Lab Invest, 2012-09-24;92(12):1712-25. 2012-09-24 [PMID: 23007134] (Western Blot, Mouse)	Western Blot	Mouse
Anne Waehre, Bente Halvorsen, Arne Yndestad, Cathrine Husberg, Ivar Sjaastad, Ståle Nygård et al. Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload PLoS ONE 4/18/2011 [PMID: 21533157]
Salgado RM, Favaro RR, Zorn TM Modulation of small leucine-rich proteoglycans (SLRPs) expression in the mouse uterus by estradiol and progesterone. Reprod. Biol. Endocrinol., 2011-02-04;9(1):22. 2011-02-04 [PMID: 21294898] (IHC-P, Mouse)	IHC-P	Mouse
Maria Vistnes, Anne Waehre, Ståle Nygård, Ivar Sjaastad, Kristin B. Andersson, Cathrine Husberg et al. Circulating cytokine levels in mice with heart failure are etiology dependent Journal of Applied Physiology 5/1/2010 [PMID: 20224000]
Salgado RM, Favaro RR, Martin SS, Zorn TM The estrous cycle modulates small leucine-rich proteoglycans expression in mouse uterine tissues. Anat Rec (Hoboken), 2009-01-01;292(1):138-53. 2009-01-01 [PMID: 18951514] (IHC, Mouse)	IHC	Mouse
Show All 12 Publications. Collapse Publications.

Array AF2745

• Lumican Antibodies
• Lumican ELISA Kit
• Lumican Lysate
• Lumican Protein
• Lumican Proteins and Enzymes
• Lumican ELISA