LIN-28A Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human LIN-28 (Protein lin-28 homolog A; CSDD1, LIN28 and ZCCHC1)  is a 30 kDa (209 amino acids) cytoplasmic RNA-binding protein with an N-terminal cold shock domain and two C-terminal CCHC zinc finger domains. It is expressed by various undifferentiated embryonic cell types and is also present in adult cardiac and skeletal muscle. Expression of LIN-28 has been shown to be regulated by micro-RNA. Human LIN-28 shares 98% and 97% amino acid sequence homology with rat and mouse LIN-28, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Pan troglodytes (Chimpanzee), Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 6 applications: ICC, IHC, IHC-P, Immunocytochemistry, Simple Western, Western Blot.

Showing Publications 1 - 10 of 22. Show All 22 Publications. Collapse Publications.

Publications using AF3757	Applications	Species
Tereshchenko, Y;Esiyok, N;Garea-Rodríguez, E;Repetto, D;Behr, R;Rodríguez-Polo, I; Transgene-Free Cynomolgus Monkey iPSCs Generated under Chemically Defined Conditions Cells 2024-03-21 [PMID: 38534402] (Immunocytochemistry, Human)	Immunocytochemistry	Human
Bekas, N;Samiotaki, M;Papathanasiou, M;Mokos, P;Pseftogas, A;Xanthopoulos, K;Thanos, D;Mosialos, G;Dafou, D; Inactivation of Tumor Suppressor CYLD Inhibits Fibroblast Reprogramming to Pluripotency Cancers 2023-10-15 [PMID: 37894364] (ICC, Mouse)	ICC	Mouse
Elie Frank, Michel Cailleret, Constantin Nelep, Pascal Fragner, Jérome Polentes, Elise Herardot et al. Semi-automated optimized method to isolate CRISPR/Cas9 edited human pluripotent stem cell clones Stem Cell Research & Therapy 2023-04-27 [PMID: 37106426]
R Kitajima, R Nakai, T Imamura, T Kameda, D Kozuka, H Hirai, H Ito, H Imai, M Imamura Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells Stem Cell Res, 2020-02-28;44(0):101749. 2020-02-28 [PMID: 32151953] (ICC, Pan troglodytes (Chimpanzee))	ICC	Pan troglodytes (Chimpanzee)
RR Pandey, D Homolka, O Olotu, R Sachidanan, N Kotaja, RS Pillai Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12 Cell Rep, 2018-09-25;24(13):3423-3432.e4. 2018-09-25 [PMID: 30257204] (IHC, Mouse)	IHC	Mouse
R Nakai, M Ohnuki, K Kuroki, H Ito, H Hirai, R Kitajima, T Fujimoto, M Nakagawa, W Enard, M Imamura Derivation of induced pluripotent stem cells in Japanese macaque (Macaca fuscata) Sci Rep, 2018-08-15;8(1):12187. 2018-08-15 [PMID: 30111816] (ICC, Primate - Macaca mulatta (Rhesus Macaque))	ICC	Primate - Macaca mulatta (Rhesus Macaque)
HM La, JA Mäkelä, AL Chan, FJ Rossello, CM Nefzger, JMD Legrand, M De Seram, JM Polo, RM Hobbs Identification of dynamic undifferentiated cell states within the male germline Nat Commun, 2018-07-19;9(1):2819. 7/19/2018 [PMID: 30026551]
AE Schaffer, MW Breuss, AO Caglayan, N Al-Sanaa, HY Al-Abdulwa, H Kaymakçala, C Y?lmaz, MS Zaki, RO Rosti, B Copeland, ST Baek, D Musaev, EC Scott, T Ben-Omran, A Karimineja, H Kayserili, F Mojahedi, M Kara, N Cai, JL Silhavy, S Elsharif, E Fenerciogl, BA Barshop, B Kara, R Wang, V Stanley, KN James, R Nachnani, A Kalur, H Megahed, F Incecik, S Danda, Y Alanay, E Faqeih, G Melikishvi, L Mansour, I Miller, B Sukhudyan, J Chelly, WB Dobyns, K Bilguvar, RA Jamra, M Gunel, JG Gleeson Biallelic loss of human CTNNA2, encoding ?N-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration Nat. Genet., 2018-07-16;0(0):. 2018-07-16 [PMID: 30013181] (ICC, Human)	ICC	Human
S Ramaswamy, N Tonnu, T Menon, BM Lewis, KT Green, D Wampler, PE Monahan, IM Verma Autologous and Heterologous Cell Therapy for Hemophilia B toward Functional Restoration of Factor IX Cell Rep, 2018-05-01;23(5):1565-1580. 2018-05-01 [PMID: 29719266] (ICC, Human)	ICC	Human
Ibrahim El‐Battrawy, Huan Lan, Lukas Cyganek, Zhihan Zhao, Xin Li, Fanis Buljubasic et al. Modeling Short QT Syndrome Using Human‐Induced Pluripotent Stem Cell–Derived Cardiomyocytes Journal of the American Heart Association 2018-04-03 [PMID: 29574456]
SD Kasowitz, M Luo, J Ma, NA Leu, PJ Wang Embryonic lethality and defective male germ cell development in mice lacking UTF1 Sci Rep, 2017-12-08;7(1):17259. 2017-12-08 [PMID: 29222434] (Western Blot, Mouse)	Western Blot	Mouse
T Shibata, Y Fujita, H Ohno, Y Suzuki, K Hayashi, KR Komatsu, S Kawasaki, K Hidaka, S Yonehara, H Sugiyama, M Endo, H Saito Protein-driven RNA nanostructured devices that function in vitro and control mammalian cell fate Nat Commun, 2017-09-14;8(1):540. 2017-09-14 [PMID: 28912471] (Simple Western, Human)	Simple Western	Human
Shunsuke Kawasaki, Yoshihiko Fujita, Takashi Nagaike, Kozo Tomita, Hirohide Saito Synthetic mRNA devices that detect endogenous proteins and distinguish mammalian cells Nucleic Acids Research 2017-07-07 [PMID: 28525643]
AR Helsel, MJ Oatley, JM Oatley Glycolysis-Optimized Conditions Enhance Maintenance of Regenerative Integrity in Mouse Spermatogonial Stem Cells during Long-Term Culture Stem Cell Reports, 2017-04-06;0(0):. 2017-04-06 [PMID: 28392219] (IHC-P, Mouse)	IHC-P	Mouse
Kellie S. Agrimson, Jennifer Onken, Debra Mitchell, Traci B. Topping, Hélio Chiarini-Garcia, Cathryn A. Hogarth et al. Characterizing the Spermatogonial Response to Retinoic Acid During the Onset of Spermatogenesis and Following Synchronization in the Neonatal Mouse Testis1 Biology of Reproduction 2016-10-13 [PMID: 27488029]
Daniel Nettersheim, Isabell Arndt, Rakesh Sharma, Stefanie Riesenberg, Sina Jostes, Simon Schneider et al. The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas British Journal of Cancer 2016-08-01 [PMID: 27441500]
Constanza J. Cortes, Helen C. Miranda, Harald Frankowski, Yakup Batlevi, Jessica E. Young, Amy Le et al. Polyglutamine-expanded androgen receptor interferes with TFEB to elicit pathological autophagy defects in SBMA Nature Neuroscience 2014-09-01 [PMID: 25108912]
Makela J, Toppari J, Rivero-Muller A, Ventela S Reconstruction of mouse testicular cellular microenvironments in long-term seminiferous tubule culture. PLoS ONE, 2014-03-11;9(3):e90088. 2014-03-11 [PMID: 24619130] (ICC, Mouse)	ICC	Mouse
Kathrin Gassei, Kyle E. Orwig SALL4 Expression in Gonocytes and Spermatogonial Clones of Postnatal Mouse Testes PLoS ONE 2013-01-11 [PMID: 23326552]
Plews JR, Li J, Jones M, Moore HD, Mason C, Andrews PW, Na J Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach. PLoS ONE, 2010-12-30;5(12):e14397. 2010-12-30 [PMID: 21209933] (Western Blot, Human)	Western Blot	Human
Sophie E. Boddington, Tobias D. Henning, Priyanka Jha, Christopher R. Schlieve, Lydia Mandrussow, David DeNardo et al. Labeling human embryonic stem cell-derived cardiomyocytes with indocyanine green for noninvasive tracking with optical imaging: an FDA-compatible alternative to firefly luciferase Cell Transplant 2010-09-01 [PMID: 20370988]
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 2007-11-30;131(5):861-72. 2007-11-30 [PMID: 18035408] (Western Blot, Human)	Western Blot	Human
Show All 22 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	ICC	Mouse	08/04/2016	View Summary Application Immunocytochemistry Sample Tested R1 wild type Mouse embryonic Stem Cells Species Mouse Lot YFC011507B

Array AF3757

• LIN-28A Antibodies
• LIN-28A Lysate
• LIN-28A Proteins